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Suggested Citation:"Appendix C Mosquito Control Strategies." National Academies of Sciences, Engineering, and Medicine. 2016. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values. Washington, DC: The National Academies Press. doi: 10.17226/23405.
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Appendix C

Mosquito Control Strategies

A list of mosquito strategies that are in use or in development are listed in Table C-1. As noted in Chapter 3 of this report, many of the strategies in use are labor intensive, reactive, and are losing their effectiveness if they work at all (Achee et al., 2015).

Suggested Citation:"Appendix C Mosquito Control Strategies." National Academies of Sciences, Engineering, and Medicine. 2016. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values. Washington, DC: The National Academies Press. doi: 10.17226/23405.
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TABLE C-1 Some Mosquito Control Strategies in Use or in Development

Name Primary Outcome(s) Key Advantage(s) Primary Challenge(s) Select References
Strategies in Usea
Long-Lasting Insecticidal Nets (LLINs) Bite prevention; population reduction Community impact Insecticide resistance; daytime biting vectors Briet and Penny, 2013;

Smith Gueye et al., 2016

Indoor Residual Spray (IRS) Population reduction Reduction of household insect pests Insecticide resistance; outdoor vector resting Zhou et al., 2010;

Yakob et al., 2011;

Smith Gueye et al., 2016

ULV/Space-spraying Population reduction Highly visible by community Insecticide resistance; delivery inside homes Esu et al., 2010;

Bonds, 2012

Larvicides and larval source management Population reduction Minimal interference with end-user lifestyle Delivery at adequate scale; insecticide resistance Fillinger and Lindsay, 2011;

Imbahale et al., 2012;

Tusting et al., 2013

Biocontrol Population reduction Resistance independent Delivery at adequate scale Scholte et al., 2006;

Majambere et al., 2007

Gravid ovitraps Population reduction Shared health ownership with community Delivery at adequate scale; maintenance Mackay et al., 2013;

Eiras et al., 2014

Personal repellents (DEET) Bite protection Use for outdoor biting; niche transmission settings (forest) End-user compliance Katz et al., 2008;

Debboun and Strickman, 2013

Strategies in Development
Attractant-Lethal Sugar Baits (ATSB) Population reduction Targets both male and female mosquitoes Effect on non-target organisms Muller et al., 2010;

Beier et al., 2012

Push-Pull Bite prevention; population reduction Targets indoor and outside biting Cost of delivery and maintenance (trap) Menger et al., 2014;

Wagman et al., 2015

Spatial Repellents Bite prevention Continual protection in treated space Cost of delivery and replacement Achee et al., 2012;

Hill et al., 2014;

Syafruddin et al., 2014

Wolbachia Population reduction; replacement Introduced symbiont in mosquitoes Infrastructure to maintain colonies; multiple releases Dobson et al., 2002;

McMeniman et al., 2009;

Moreira et al., 2009;

Bian et al., 2010;

WHO, 2010;

Hoffmann et al., 2011;

Iturbe-Ormaetxe et al., 2011

Suggested Citation:"Appendix C Mosquito Control Strategies." National Academies of Sciences, Engineering, and Medicine. 2016. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values. Washington, DC: The National Academies Press. doi: 10.17226/23405.
×
Name Primary Outcome(s) Key Advantage(s) Primary Challenge(s) Select References
Release of Insects with Dominant Lethality (RIDL) Population reduction Release of non-biting males Infrastructure to maintain colonies; multiple releases Atkinson et al., 2007;

Phuc et al., 2007;

Alphey et al., 2010;

WHO, 2010

Pyriproxyfen (PPF) Population reduction Target of cryptic habitats Density-dependent phenomena Devine and Killeen, 2010;

Harris et al., 2013;

Lwetoijera et al., 2014;

Koama et al., 2015

aRecommended by the World Health Organization.

Source: Modified from Achee et al., 2015.

Suggested Citation:"Appendix C Mosquito Control Strategies." National Academies of Sciences, Engineering, and Medicine. 2016. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values. Washington, DC: The National Academies Press. doi: 10.17226/23405.
×

REFERENCES

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Achee, N.L., F. Gould, T.A. Perkins, R.C. Reiner Jr, A.C. Morrison, S.A. Ritchie, et al., 2015. A Critical Assessment of Vector Control for Dengue Prevention. PLoS Negl Trop Dis 9(5): e0003655. doi:10.1371/journal.pntd.0003655.

Alphey, L., M. Benedict, R. Bellini, G. Clark, D. Dame, M. Service, and S. Dobson. 2010. Sterile-insect methods for control of mosquito-borne diseases: An analysis. Vector-Borne Zoonotic Dis. 10(3):295-311.

Atkinson, M.P., Z. Su, N. Alphey, L.S. Alphey, P.G. Coleman, and L.M. Wein. 2007. Analyzing the control of mosquito-borne diseases by a dominant lethal genetic system. Proc. Natl. Acad. Sci. 104(22):9540-9545.

Beier, J.C., G.C. Muller, W.D. Gu, K.L. Arheart, and Y. Schlein. 2012. Attractive toxic sugar bait (ATSB) methods decimate populations of Anopheles malaria vectors in arid environments regardless of the local availability of favoured sugar-source blossoms. Malar. J. 11:31.

Bian, G.W., Y. Xu, P. Lu, Y. Xie, and Z.Y. Xi. 2010. The endosymbiotic bacterium Wolbachia induces resistance to dengue virus in Aedes aegypti. Plos Pathog. 6(4):e1000833.

Bonds, J.A.S. 2012. Ultra-low-volume space sprays in mosquito control: A critical review. Med. Vet. Entomol. 26(2):1211-1230.

Briet, O.J., and M.A. Penny. 2013. Repeated mass distributions and continuous distribution of long-lasting insecticidal nets: Modelling sustainability of health benefits from mosquito nets, depending on case management. Malar. J. 12:401.

Debboun, M., and D. Strickman. 2013. Insect repellents and associated personal protection for a reduction in human disease. Med. Vet. Entomol. 27(1):1-9.

Devine, G.J., and G.F. Killeen. 2010. The potential of a new larviciding method for the control of malaria vectors. Malar. J. 9:142.

Dobson, S.L., C.W. Fox, and F.M. Jiggins. 2002. The effect of Wolbachia-induced cytoplasmic incompatibility on host population size in natural and manipulated systems. Proc. Biol. Sci. 269(1490):437-445.

Eiras, A.E., T.S. Buhagiar, and S.A. Ritchie. 2014. Development of the gravid Aedes trap for the capture of adult female container-exploiting mosquitoes (Diptera: Culicidae). J. Med. Entomol. 51(1):200-209.

Esu, E., A. Lenhart, L. Smith, and O. Horstick. 2010. Effectiveness of peridomestic space spraying with insecticide on dengue transmission: Systematic review. Trop. Med. Int. Health 15(5):619-631.

Fillinger, U., and S.W. Lindsay. 2011. Larval source management for malaria control in Africa: Myths and reality. Malar. J. 10:353.

Harris, C., D.W. Lwetoijera, S. Dongus, N.S. Matowo, L.M. Lorenz, G.J. Devine, and S. Majambere. 2013. Sterilising effects of pyriproxyfen on Anopheles arabiensis and its potential use in malaria control. Parasit. Vectors 6:144.

Hill, N., H.N. Zhou, P.Y. Wang, X.F. Guo, I. Carneiro, and S.J. Moore. 2014. A household randomized, controlled trial of the efficacy of 0.03% transfluthrin coils alone and in combination with long-lasting insecticidal nets on the incidence of Plasmodium. Malar. J. 13:208.

Hoffmann, A.A., B.L. Montgomery, J. Popovici, I. Iturbe-Ormaetxe, P.H. Johnson, F. Muzzi, M. Greenfield, M. Durkan, Y.S. Leong, Y. Dong, H. Cook, J. Axford, A.G. Callahan, N. Kenny, C. Omodei, E.A. McGraw, P.A. Ryan, S.A. Ritchie, M. Turelli, and S.L. O’Neill. 2011. Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission. Nature 476(7361):454-457.

Imbahale, S.S., A. Githeko, W.R. Mukabana, and W. Takken. 2012. Integrated mosquito larval source management reduces larval numbers in two highland villages in western Kenya. BMC Public Health 12:10.

Iturbe-Ormaetxe, I., T. Walker, and S.L. Neill. 2011. Wolbachia and the biological control of mosquito-borne disease. Embo Rep. 12(6):508-518.

Katz, T.M., J.H. Miller, and A.A. Hebert. 2008. Insect repellents: Historical perspectives and new developments. J. Am. Acad. Dermatol. 58(5):865-871.

Koama, B., M. Namountougou, R. Sanou, S. Ndo, A. Ouattara, R.K. Dabire, D. Malone, and A. Diabate. 2015. The sterilizing effect of pyriproxyfen on the malaria vector Anopheles gambiae: Physiological impact on ovaries development. Malar. J. 14:101.

Lwetoijera, D.W., C. Harris, S.S. Kiware, G.F. Killeen, S. Dongus, G.J. Devine, and S. Majambere. 2014. Comprehensive sterilization of malaria vectors using pyri-proxyfen: A step closer to malaria elimination. Am. J. Trop. Med. Hyg. 90(5):852-855.

Suggested Citation:"Appendix C Mosquito Control Strategies." National Academies of Sciences, Engineering, and Medicine. 2016. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values. Washington, DC: The National Academies Press. doi: 10.17226/23405.
×

Mackay, A.J., M. Amador, and R. Barrera. 2013. An improved autocidal gravid ovitrap for the control and surveillance of Aedes aegypti. Parasit Vectors 6:13.

Majambere, S., S.W. Lindsay, C. Green, B. Kandeh, and U. Fillinger. 2007. Microbial larvicides for malaria control in The Gambia. Malar. J. 6:76.

McMeniman, C.J., R.V. Lane, B.N. Cass, A.W. Fong, M. Sidhu, Y.F. Wang, and S.L. O’Neill. 2009. Stable introduction of a life-shortening Wolbachia infection into the mosquito Aedes aegypti. Science 323(5910):141-144.

Menger, D.J., B. Otieno, M. de Rijk, W.R. Mukabana, J.J. van Loon, and W. Takken. 2014. A push-pull system to reduce house entry of malaria mosquitoes. Malar. J. 13:119.

Menger, D.J., P. Omusula, M. Holdinga, T. Homan, A.S. Carreira, P. Vandendaele, J.L. Derycke, C.K. Mweresa, W.R. Mukabana, J.J. van Loon, and W. Takken. 2015. Field evaluation of a push-pull system to reduce malaria transmission. PLoS ONE 10(4):e0123415.

Moreira, L.A., I. Iturbe-Ormaetxe, J.A. Jeffery, G.J. Lu, A.T. Pyke, L.M. Hedges, B.C. Rocha, S. Hall-Mendelin, A. Day, M. Riegler, L.E. Hugo, K.N. Johnson, B.H. Kay, E.A. McGraw, A.F. van den Hurk, P.A. Ryan, and S.L. O’Neill. 2009. A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium. Cell 139(7):1268-1278.

Muller, G.C., J.C. Beier, S.F. Traore, M.B. Toure, M.M. Traore, S. Bah, S. Doumbia, and Y. Schlein. 2010. Successful field trial of attractive toxic sugar bait (ATSB) plant—spraying methods against malaria vectors in the Anopheles gambiae complex in Mali, West Africa. Malar. J. 9:210.

Phuc, H.K., M.H. Andreasen, R.S. Burton, C. Vass, M.J. Epton, G. Pape, G. Fu, K.C. Condon, S. Scaife, C.A. Donnelly, P.G. Coleman, H. White-Cooper, and L. Alphey. 2007. Late-acting dominant lethal genetic systems and mosquito control. BMC Biol. 5:11.

Scholte, E.J., B.G. Knols, and W. Takken. 2006. Infection of the malaria mosquito Anopheles gambiae with the entomopathogenic fungus Metarhizium anisopliae reduces blood feeding and fecundity. J. Invertebr. Pathol. 91(1):43-49.

Smith Gueye, C., G. Newby, R.D. Gosling, M.A. Whittaker, D. Chandramohan, L. Slutsker, and M. Tanner. 2016. Strategies and approaches to vector control in nine malaria-eliminating countries: A cross-case study analysis. Malar. J. 15(1):2.

Syafruddin, D., M.J. Bangs, D. Sidik, I. Elyazar, P.B. Asih, K. Chan, S. Nurleila, C. Nixon, J. Hendarto, I. Wahid, H. Ishak, C. Bøgh, J.P. Grieco, N.L. Achee, and J.K. Baird. 2014. Impact of a spatial repellent on malaria incidence in two villages in Sumba, Indonesia. Am. J. Trop. Med. Hyg. 91(6):1079-1087.

Tusting, L.S., J. Thwing, D. Sinclair, U. Fillinger, J. Gimnig, K.E. Bonner, C. Bottomley, and S.W. Lindsay. 2013. Mosquito larval source management for controlling malaria. Cochrane Database Syst. Rev. 8:CD008923.

Wagman, J.M., J.P. Grieco, K. Bautista, J. Polanco, I. Briceo, R. King, and N.L. Achee. 2015. The field evaluation of a push-pull system to control malaria vectors in Northern Belize, Central America. Malar. J. 14:11.

WHO (World Health Organization). 2010. Progress and Prospects for the Use of Genetically Modified Mosquitoes to Inhibit Disease Transmission [online]. Available at http://apps.who.int/iris/bitstream/10665/44297/1/9789241599238_eng.pdf [accessed April 25, 2016].

Yakob, L., R. Dunning, and G.Y. Yan. 2011. Indoor residual spray and insecticide-treated bednets for malaria control: Theoretical synergisms and antagonisms. J. R. Soc. Interface 8(59):799-806.

Zhou, G.F., A.K. Githeko, N. Minakawa, and G.Y. Yan. 2010. Community-wide benefits of targeted indoor residual spray for malaria control in the Western Kenya Highland. Malar. J. 9:9.

Suggested Citation:"Appendix C Mosquito Control Strategies." National Academies of Sciences, Engineering, and Medicine. 2016. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values. Washington, DC: The National Academies Press. doi: 10.17226/23405.
×
Page 192
Suggested Citation:"Appendix C Mosquito Control Strategies." National Academies of Sciences, Engineering, and Medicine. 2016. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values. Washington, DC: The National Academies Press. doi: 10.17226/23405.
×
Page 193
Suggested Citation:"Appendix C Mosquito Control Strategies." National Academies of Sciences, Engineering, and Medicine. 2016. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values. Washington, DC: The National Academies Press. doi: 10.17226/23405.
×
Page 194
Suggested Citation:"Appendix C Mosquito Control Strategies." National Academies of Sciences, Engineering, and Medicine. 2016. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values. Washington, DC: The National Academies Press. doi: 10.17226/23405.
×
Page 195
Suggested Citation:"Appendix C Mosquito Control Strategies." National Academies of Sciences, Engineering, and Medicine. 2016. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values. Washington, DC: The National Academies Press. doi: 10.17226/23405.
×
Page 196
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Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration.

Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

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