National Academies Press: OpenBook

Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 20 (2016)

Chapter: Appendix A Biographical Information Committee on Acute Exposure Guidelines for Chloroformates

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Suggested Citation:"Appendix A Biographical Information Committee on Acute Exposure Guidelines for Chloroformates." National Academies of Sciences, Engineering, and Medicine. 2016. Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 20. Washington, DC: The National Academies Press. doi: 10.17226/23634.
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Appendix A

Biographical Information Committee on Acute Exposure Guidelines for Chloroformates

GEORGE RUSCH is a Senior Scientist at Risk Assessment and Toxicology Services. He is an expert on the toxicology of fluorocarbon refrigerants, foam blowing agents and solvents and he has worked with the U.S. Environmental Protection Agency (EPA) and the European Chemical Authority in the approval and registration of new chemical products. He previously served as the chair of the EPA’s National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances and has served on the following National Research Council committees: the Committee on Toxicology; the Committee on Assessment of Fire Suppression Substitutes and Alternatives to Halon; and the Subcommittee on Iodotrifluoromethane: Toxicological Review. He has served on other advisory boards for the EPA and Department of Energy and he is the founding chair and current member of the American Industrial Hygiene Association’s Emergency Response Planning Committee. He is currently an elected fellow of the Academy of Toxicological Sciences and a fellow of the American Industrial Hygiene Association. He received his PhD from Adelphi University.

RICHARD A. BECKER is a Senior Toxicologist at the American Chemistry Council (ACC). He leads ACC’s Science and Research Division, and directs ACC’s Long-Range Research Initiative, an innovative research program designed to modernize and improve chemical safety assessments. From 1999 to 2014 he served in ACC’s Regulatory and Technical Affairs Department focusing on emerging health risk science issues, including advanced molecular screening methods in toxicity evaluation and risk assessment, human biomonitoring, sensitive subpopulations, endocrine screening and testing and alternative test methods. Previously, he held technical and scientific management positions in California state government. He received the Arnold Lehman Award from the Society of Toxicology in 2015 in recognition of his contributions to risk assessment and the regulation of chemicals. He is a diplomate of the American Board of Toxicology. Dr. Becker currently supports the Academies as a member of the Board on Environmental Studies and Toxicology. Dr. Becker received his PhD in pharmacology and toxicology from the University of California, Irvine.

Suggested Citation:"Appendix A Biographical Information Committee on Acute Exposure Guidelines for Chloroformates." National Academies of Sciences, Engineering, and Medicine. 2016. Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 20. Washington, DC: The National Academies Press. doi: 10.17226/23634.
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JACOB MCDONALD is Vice President of Applied Sciences at the Lovelace Respiratory Research Institute. He oversees contract research at the institute, and conducts research that bridges his education and experience in analytical chemistry, aerosol science, and toxicology. His work spans the study of complex mixtures, respiratory drug delivery, animal model development, and metabolism in mammals. He has more than 120 peer-reviewed publications and 2 book chapters. Dr. McDonald served on the National Research Council Committee to Review the Army’s Enhanced Particulate Matter Surveillance Project Report and the Institute of Medicine Committee on the Long-Term Health Consequences of Exposure to Burn Pits in Iraq and Afghanistan. He earned a PhD in environmental chemistry and toxicology from the University of Nevada.

ROBERTA GRANT is a retired toxicologist at the Texas Commission on Environmental Quality where she managed staff conducting toxicological evaluations of air permit applications, monitoring projects, risk assessments, and toxicity assessments to develop acute and chronic inhalation toxicity factors. Dr. Grant has developed inhalation acute and chronic toxicity factors for several chemicals: 1,3-butadiene, three butene isomers, methacrolein, 4-vinylcyclo-hexene, crotonaldehyde, pentene isomers, crystalline silica, nickel compounds, and arsenic compounds. She has served on the Environmental Protection Agency’s National Advisory Committee for Developing Acute Exposure Guideline Levels and on three Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) Scientific Advisory Panels. Dr. Grant served on the National Research Council Committee to Review California’s Risk Assessment Process for Pesticides. Dr. Grant received a PhD in toxicology from the College of Pharmacy, The University of Texas at Austin.

NU-MAY RUBY REED is a retired toxicologist with the California Environmental Protection Agency (Cal/EPA) Department of Pesticide Regulation, where she led risk-assessment issues in the Health Assessment Section. Her research interests are in evaluating health risks and developing risk assessment guidelines for pesticides. She has been on several Cal/EPA working groups that initiate, research, and revise risk-assessment guidelines and policies. Dr. Reed represented her department in task forces on community concerns and emergency response, risk-management guidance, and public education. She taught health risk assessment at the University of California, Davis, for more than 15 years. Dr. Reed served on the National Research Council Subcommittee on Fluoride in Drinking Water, on the Standing Committee on Risk Analysis Issues and Reviews, and on the Committee for Acute Exposure Guideline Levels, and on numerous Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) Scientific Advisory Panels. She received her PhD from the University of California, Davis, and is a diplomate of the American Board of Toxicology.

Suggested Citation:"Appendix A Biographical Information Committee on Acute Exposure Guidelines for Chloroformates." National Academies of Sciences, Engineering, and Medicine. 2016. Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 20. Washington, DC: The National Academies Press. doi: 10.17226/23634.
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Page 133
Suggested Citation:"Appendix A Biographical Information Committee on Acute Exposure Guidelines for Chloroformates." National Academies of Sciences, Engineering, and Medicine. 2016. Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 20. Washington, DC: The National Academies Press. doi: 10.17226/23634.
×
Page 134
Next: Appendix B Benchmark Concentration Calculations for Selected Chloroformates »
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 20 Get This Book
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Extremely hazardous substances can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where these substances are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents.

Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 20 reviews and updates the technical support document on acute exposure guideline levels (AEGLs) for selected chloroformates. This update focuses on establishing AEGL-3 values for n-propyl chloroformate and isopropyl chloroformate, but will also consider whether any new data are available that would affect the proposed values for the other 10 chloroformates.

AEGLs represent threshold exposure limits (exposure levels below which adverse health effects are not likely to occur) for the general public and are applicable to emergency exposures ranging from 10 minutes (min) to 8 h. Three levels - AEGL-1, AEGL-2, and AEGL-3 - are developed for each of five exposure periods (10 min, 30 min, 1 h, 4 h, and 8 h) and are distinguished by varying degrees of severity of toxic effects. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites.

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