A
Workshop Agenda
The State of the Science in the Field of Regenerative Medicine:
Challenges of and Opportunities for Cellular Therapies: A
Workshop
October 13, 2016
National Academy of Sciences Building
Room 125
2101 Constitution Avenue, NW
Washington, DC 20418
| MEETING OBJECTIVES | |
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| AGENDA | |
| 8:30 a.m. | Welcoming Remarks |
| R. Alta Charo, Forum Co-Chair | |
| Warren P. Knowles Professor of Law and Bioethics | |
| School of Law and School of Medicine and Public Health | |
| University of Wisconsin–Madison | |
| Jay Siegel, Forum Co-Chair | |
| Chief Biotechnology Officer | |
| Head, Scientific Strategy and Policy | |
| Johnson & Johnson | |
| INTRODUCTION: OVERVIEW OF THE FIELD OF REGENERATIVE MEDICINE AND FOCUS OF THE WORKSHOP | |
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Objectives: To describe and explore the broad field of regenerative therapies at a high level and to highlight successful research and clinical applications as well as barriers to scientific and therapeutic advances as the field moves forward. |
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| 8:35 a.m. | Charge to Workshop Speakers and Participants: Considering the State of the Science in Regenerative Therapies |
| Cynthia Dunbar, Workshop Co-Chair | |
| President | |
| American Society of Gene and Cell Therapy | |
| Senior Investigator, Molecular Hematopoiesis Section | |
| National Heart, Lung, and Blood Institute | |
| 8:45 a.m. | Areas of Challenge and Success in Regenerative Therapies |
| Lorenz Studer | |
| Director, Center for Stem Cell Biology | |
| Memorial Sloan Kettering Cancer Center | |
| 9:05 a.m. | Clarifying Questions |
| SESSION I: SKIN AND MUSCULOSKELETAL TISSUES | |
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Objectives: To examine the state of the science in research and novel applications of new technology to repair, regenerate, or renew skin or musculoskeletal tissues; to consider the obstacles that hinder progress in research; and to |
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highlight scientific successes, lessons learned, and opportunities to move the field forward with the goal of bringing new therapies to patients. |
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Moderator: Audrey Kusiak, Scientific Program Manager, Rehabilitation Research and Development Service, Office of Research and Development, Department of Veterans Affairs |
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| 9:15 a.m. | Anthony Oro |
| Professor of Dermatology | |
| Member of Program in Epithelial Biology, Institute for Stem Cell Biology and Regenerative Medicine | |
| Stanford University | |
| Anthony Ratcliffe | |
| President and Chief Executive Officer | |
| Synthasome, Inc. | |
| Patricia Furlong | |
| Chief Executive Officer | |
| Parent Project Muscular Dystrophy | |
| 10:00 a.m. | Discussion with Speakers and Attendees |
| 10:30 a.m. | Break |
| SESSION II: HEMATOLOGY AND IMMUNITY | |
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Objectives: To examine the state of the science in research and novel applications of new technology to repair, regenerate, or renew tissue and function in the blood and the immune system; to consider the obstacles that hinder progress in research; and to highlight scientific successes, lessons learned, and opportunities to move the field forward with the goal of bringing new therapies to patients. |
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Moderator: Cynthia Dunbar, President, American Society of Gene and Cell Therapy; Senior Investigator, Molecular Hematopoiesis Section, National Heart, Lung, and Blood Institute |
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| 10:45 a.m. | Fyodor Urnov |
| Associate Director | |
| Altius Institute for Biomedical Sciences | |
| Harry Malech | |
| Chief, Laboratory of Host Defenses | |
| Chief, Genetic Immunotherapy Section | |
| National Institute of Allergy and Infectious Diseases | |
| Michel Sadelain | |
| Director, Center for Cell Engineering and Gene | |
| Transfer and Gene Expression Laboratory | |
| Memorial Sloan Kettering Cancer Center | |
| 11:30 a.m. | Patient Perspective |
| Jennifer Fields | |
| Patient Advocate | |
| 11:35 a.m. | Discussion with Speakers and Attendees |
| 12:00 p.m. | Working Lunch |
| SESSION III: NEUROLOGICAL AND OPHTHALMOLOGICAL TISSUES | |
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Objectives: To examine the state of the science in research and novel applications of new technology to repair, regenerate, or renew neurological and ophthalmological tissues; to consider the obstacles that hinder progress in research; and to highlight scientific successes, lessons learned, and opportunities to move the field forward with the goal of bringing new therapies to patients. |
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Moderator: Brian Fiske, Senior Vice President, Research Programs, The Michael J. Fox Foundation for Parkinson’s Research |
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| 1:00 p.m. | Sally Temple |
| Principal Investigator and Scientific Director | |
| Neural Stem Cell Institute | |
| Ann Tsukamoto | |
| Former Executive Vice President, Scientific and Strategic Alliances | |
| StemCells, Inc. | |
| Peter Coffey | |
| Professor, Neuroscience Research Institute | |
| University of California, Santa Barbara | |
| 1:45 p.m. | Discussion with Speakers and Attendees |
| SESSION IV: CARDIOVASCULAR AND LUNG TISSUES | |
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Objectives: To examine the state of the science in research and novel applications of new technology to repair, regenerate, or renew cardiovascular and lung tissues; to consider the obstacles that hinder progress in research; and to highlight scientific successes, lessons learned, and opportunities to move the field forward with the goal of bringing new therapies to patients. |
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Moderator: Jiwen Zhang, Senior Director, Regulatory Affairs, Cell Therapy and Regenerative Medicine, GE Healthcare |
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| 2:15 p.m. | Deepak Srivastava |
| The Younger Family Director, Gladstone | |
| Institute of Cardiovascular Disease; Director, Rodenberry Center for Stem Cell Biology and Medicine; Professor, University of California, San Francisco | |
| Eduardo Marbán Director, Heart Institute Professor of Medicine Cedars-Sinai Brigitte Gomperts Associate Professor, Pulmonary and Pediatric Medicine University of California, Los Angeles |
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| 3:00 p.m. | Discussion with Speakers and Attendees |
| 3:30 p.m. | Break |
| SESSION V: RENAL TISSUES | |
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Objectives: To examine the state of the science in research and novel applications of new technology in repairing or regenerating tissue in the kidney, to consider the obstacles that hinder progress in research; and to highlight scientific successes, lessons learned, and opportunities to move the field forward with the goal of bringing new therapies to patients. |
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Moderator: Deborah Hoshizaki, Program Director, Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases |
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| 3:45 p.m. | Ben Humphreys |
| Chief, Renal Diseases Division, Department of Medicine | |
| Washington University School of Medicine | |
| David Baron | |
| Chief Scientific Officer | |
| PKD Foundation | |
| 4:15 p.m. | Discussion with Speakers and Attendees |
| SESSION VI: FINAL DISCUSSION AND NEXT STEPS | |
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Objectives: To reflect on the current state of the science of regenerative therapies, explore the existing and potential scientific barriers to advancing the field of regenerative medicine, and to discuss strategies and lessons learned for facilitating efficient, effective, and translatable research. |
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Moderator: Alta Charo, Warren P. Knowles Professor of Law and Bioethics School of Law and School of Medicine and Public Health, University of Wisconsin–Madison |
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| 4:35 p.m. | Looking Toward the Future: The Promise and Challenges of Regenerative Therapies |
| George Daley | |
| Director, Stem Cell Transplantation Program | |
| Boston Children’s Hospital and Dana–Farber Cancer Institute | |
| Dean, Harvard Medical School | |
| 4:55 p.m. | Reflections on the Day/Next Steps |
| Patricia Furlong | |
| Chief Executive Officer | |
| Parent Project Muscular Dystrophy | |
| Deepak Srivastava | |
| The Younger Family Director, Gladstone | |
| Institute of Cardiovascular Disease; Director, Rodenberry Center for Stem Cell Biology and Medicine; Professor, University of California, San Francisco | |
| Sally Temple | |
| Principal Investigator and Scientific Director | |
| Neural Stem Cell Institute | |
| Ann Tsukamoto | |
| Former Executive Vice President, Scientific and Strategic Alliances | |
| StemCells, Inc. | |
| 5:15 p.m. | Discussion with Speakers and Attendees |
| 5:35 p.m. | Concluding Remarks |
| R. Alta Charo, Forum Co-Chair | |
| Warren P. Knowles Professor of Law and Bioethics | |
| School of Law and School of Medicine and Public Health | |
| University of Wisconsin–Madison | |
| Cynthia Dunbar, Workshop Co-Chair | |
| President | |
| American Society of Gene and Cell Therapy | |
| Senior Investigator, Molecular Hematopoiesis Section | |
| National Heart, Lung, and Blood Institute | |
| 5:45 p.m. | ADJOURN |
