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References
Absinta, M., P. Sati, M. I. Gaitan, P. Maggi, I. C. Cortese, M. Filippi, and D. S. Reich. 2013. Seven-Tesla phase imaging of acute multiple sclerosis lesions: A new window into the inflammatory process. Annals of Neurology 74(5):669-678.
Absinta, M., L. Vuolo, A. Rao, G. Nair, P. Sati, I. C. Cortese, J. Ohayon, K. Fenton, M. I. Reyes-Mantilla, D. Maric, P. A. Calabresi, J. A. Butman, C. A. Pardo, and D. S. Reich. 2015. Gadolinium-based MRI characterization of leptomeningeal inflammation in multiple sclerosis. Neurology 85(1):18-28.
Absinta, M., P. Sati, M. Schindler, E. C. Leibovitch, J. Ohayon, T. Wu, A. Meani, M. Filippi, S. Jacobson, I. C. Cortese, and D. S. Reich. 2016. Persistent 7-Tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions. Journal of Clinical Investigation 126(7):2597-2609.
Adams, R. A., J. Bauer, M. J. Flick, S. L. Sikorski, T. Nuriel, H. Lassmann, J. L. Degen, and K. Akassoglou. 2007. The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. Journal of Experimental Medicine 204(3):571-582.
Albrecht, D. S., C. Granziera, J. M. Hooker, and M. L. Loggia. 2016. In vivo imaging of human neuroinflammation. ACS Chemical Neuroscience 7(4):470-483.
Atkins, H. L., M. Bowman, D. Allan, G. Anstee, D. L. Arnold, A. Bar-Or, I. Bence-Bruckler, P. Birch, C. Bredeson, J. Chen, D. Fergusson, M. Halpenny, L. Hamelin, L. Huebsch, B. Hutton, P. Laneuville, Y. Lapierre, H. Lee, L. Martin, S. McDiarmid, P. O’Connor, T. Ramsay, M. Sabloff, L. Walker, and M. S. Freedman. 2016. Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: A multicentre single-group Phase 2 trial. The Lancet 388(10044):576-585.
Bar-Or, A., L. Fawaz, B. Fan, P. J. Darlington, A. Rieger, C. Ghorayeb, P. A. Calabresi, E. Waubant, S. L. Hauser, J. Zhang, and C. H. Smith. 2010. Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS? Annals of Neurology 67(4):452-461.
Bellingrath, S., N. Rohleder, and B. M. Kudielka. 2013. Effort-reward-imbalance in healthy teachers is associated with higher LPS-stimulated production and lower glucocorticoid sensitivity of interleukin-6 in vitro. Biological Psychology 92(2):403-409.
Bianchin, M. M., H. M. Capella, D. L. Chaves, M. Steindel, E. C. Grisard, G. G. Ganev, J. P. da Silva, Jr., S. Neto Evaldo, M. A. Poffo, R. Walz, C. G. Carlotti, Jr., and A. C. Sakamoto. 2004. Nasu-Hakola disease (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy—PLOSL): A dementia associated with bone cystic lesions. From clinical to genetic and molecular aspects. Cellular and Molecular Neurobiology 24(1):1-24.
Brietzke, E., R. B. Mansur, J. K. Soczynska, F. Kapczinski, R. A. Bressan, and R. S. McIntyre. 2012. Towards a multifactorial approach for prediction of bipolar disorder in at risk populations. Journal of Affective Disorders 140(1):82-91.
Bullmore, E. T., and M. E. Lynall. 2014. Immunologic therapeutics and psychotic disorders. Biological Psychiatry 75(4):260-261.
Choi, H. B., J. K. Ryu, S. U. Kim, and J. G. McLarnon. 2007. Modulation of the purinergic p2x7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain. Journal of Neuroscience 27(18):4957-4968.
Ciccarelli, O., F. Barkhof, B. Bodini, N. De Stefano, X. Golay, K. Nicolay, D. Pelletier, P. J. Pouwels, S. A. Smith, C. A. Wheeler-Kingshott, B. Stankoff, T. Yousry, and D. H. Miller. 2014. Pathogenesis of multiple sclerosis: Insights from molecular and metabolic imaging. Lancet Neurology 13(8):807-822.
Claudio, L., Y. Kress, W. T. Norton, and C. F. 1989. Brosnan. Increased vesicular transport and decreased mitochondrial content in blood–brain barrier endothelial cells during experimental autoimmune encephalomyelitis. American Journal of Pathology 135(6):1157-1168.
Cortes-Canteli, M., J. Paul, E. H. Norris, R. Bronstein, H. J. Ahn, D. Zamolodchikov, S. Bhuvanendran, K. M. Fenz, and S. Strickland. 2010. Fibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: A possible contributing factor to Alzheimer’s disease. Neuron 66(5):695-709.
Cortes-Canteli, M., L. Mattei, A. T. Richards, E. H. Norris, and S. Strickland. 2015. Fibrin deposited in the Alzheimer’s disease brain promotes neuronal degeneration. Neurobiology of Aging 36(2):608-617.
Craig-Schapiro, R., M. Kuhn, C. Xiong, E. H. Pickering, J. Liu, T. P. Misko, R. J. Perrin, K. R. Bales, H. Soares, A. M. Fagan, and D. M. Holtzman. 2011. Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer’s disease diagnosis and prognosis. PLoS ONE 6(4):e18850.
Daneman, R., L. Zhou, A. A. Kebede, and B. A. Barres. 2010. Pericytes are required for blood‒brain barrier integrity during embryogenesis. Nature 468(7323):562-566.
Davalos, D., J. K. Ryu, M. Merlini, K. M. Baeten, N. Le Moan, M. A. Petersen, T. J. Deerinck, D. S. Smirnoff, C. Bedard, H. Hakozaki, S. Gonias Murray, J. B. Ling, H. Lassmann, J. L. Degen, M. H. Ellisman, and K. Akassoglou. 2012. Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nature Communications 3:1227.
Davalos, D., K. M. Baeten, M. A. Whitney, E. S. Mullins, B. Friedman, E. S. Olson, J. K. Ryu, D. S. Smirnoff, M. A. Petersen, C. Bedard, J. L. Degen, R. Y. Tsien, and K. Akassoglou. 2014. Early detection of thrombin activity in neuroinflammatory disease. Annals of Neurology 75(2):303-308.
Fagan, A. M., and R. J. Perrin. 2012. Upcoming candidate cerebrospinal fluid biomarkers of Alzheimer’s disease. Biomarkers in Medicine 6(4):455-476.
Ferguson, S., B. Mouzon, D. Paris, D. Aponte, L. Abdullah, W. Stewart, M. Mullan, and F. Crawford. 2017. Acute or delayed treatment with anatabine improves spatial memory and reduces pathological sequelae at late time-points after repetitive mild traumatic brain injury. Journal of Neurotrauma 34(8):1676-1691.
Guerreiro, R., A. Wojtas, J. Bras, M. Carrasquillo, E. Rogaeva, E. Majounie, C. Cruchaga, C. Sassi, J. S. Kauwe, S. Younkin, L. Hazrati, J. Collinge, J. Pocock, T. Lashley, J. Williams, J. C. Lambert, P. Amouyel, A. Goate, R. Rademakers, K. Morgan, J. Powell, P. St. George-Hyslop, A. Singleton, J. Hardy, and Alzheimer Genetic Analysis Group. 2013. TREM2 variants in Alzheimer’s disease. New England Journal of Medicine 368(2):117-127.
Haapakoski, R., J. Mathieu, K. P. Ebmeier, H. Alenius, and M. Kivimaki. 2015. Cumulative meta-analysis of interleukins 6 and 1beta, tumour necrosis factor alpha and C-reactive protein in patients with major depressive disorder. Brain Behavior and Immunity 49:206-215.
Han, M. H., S. I. Hwang, D. B. Roy, D. H. Lundgren, J. V. Price, S. S. Ousman, G. H. Fernald, B. Gerlitz, W. H. Robinson, S. E. Baranzini, B. W. Grinnell, C. S. Raine, R. A. Sobel, D. K. Han, and L. Steinman. 2008. Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature 451(7182):1076-1081.
Harrison, N. A., L. Brydon, C. Walker, M. A. Gray, A. Steptoe, and H. D. Critchley. 2009. Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biological Psychiatry 66(5):407-414.
Hauser, S. L., A. Bar-Or, G. Comi, G. Giovannoni, H. P. Hartung, B. Hemmer, F. Lublin, X. Montalban, K. W. Rammohan, K. Selmaj, A. Traboulsee, J. S. Wolinsky, D. L. Arnold, G. Klingelschmitt, D. Masterman, P. Fontoura, S. Belachew, P. Chin, N. Mairon, H. Garren, L. Kappos, and OPERA I and OPERA II Clinical Investigators. 2017. Ocrelizumab versus interferon beta-
1a in relapsing multiple sclerosis. New England Journal of Medicine 376(3):221-234.
Hess, A., R. Axmann, J. Rech, S. Finzel, C. Heindl, S. Kreitz, M. Sergeeva, M. Saake, M. Garcia, G. Kollias, R. H. Straub, O. Sporns, A. Doerfler, K. Brune, and G. Schett. 2011. Blockade of TNF-alpha rapidly inhibits pain responses in the central nervous system. Proceedings of the National Academy of Sciences 108(9):3731-3736.
Hickman, S. E., N. D. Kingery, T. K. Ohsumi, M. L. Borowsky, L. C. Wang, T. K. Means, and J. El Khoury. 2013. The microglial sensome revealed by direct RNA sequencing. Nature Neuroscience 16(12):1896-1905.
Jay, T. R., C. M. Miller, P. J. Cheng, L. C. Graham, S. Bemiller, M. L. Broihier, G. Xu, D. Margevicius, J. C. Karlo, G. L. Sousa, A. C. Cotleur, O. Butovsky, L. Bekris, S. M. Staugaitis, J. B. Leverenz, S. W. Pimplikar, G. E. Landreth, G. R. Howell, R. M. Ransohoff, and B. T. Lamb. 2015. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models. Journal of Experimental Medicine 212(3):287-295.
Khandaker, G. M., R. M. Pearson, S. Zammit, G. Lewis, and P. B. Jones. 2014. Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: A population-based longitudinal study. JAMA Psychiatry 71(10):1121-1128.
Kirk, J., J. Plumb, M. Mirakhur, and S. McQuaid. 2003. Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood–brain barrier leakage and active demyelination. The Journal of Pathology 201(2):319-327.
Kreisl, W. C., C. H. Lyoo, M. McGwier, J. Snow, K. J. Jenko, N. Kimura, W. Corona, C. L. Morse, S. S. Zoghbi, V. W. Pike, F. J. McMahon, R. S. Turner, R. B. Innis, and Biomarkers Consortium PET Radioligand Project Team. 2013. In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease. Brain 136(Pt 7):2228-2238.
Lee, J. W., H. Namkoong, H. K. Kim, S. Kim, D. W. Hwang, H. R. Na, S.-A. Ha, J.-R. Kim, and J. W. Kim. 2007. Fibrinogen gamma-A chain precursor in CSF: A candidate biomarker for Alzheimer’s disease. BMC Neurology 7(14).
Li, R., A. Rezk, Y. Miyazaki, E. Hilgenberg, H. Touil, P. Shen, C. S. Moore, L. Michel, F. Althekair, S. Rajasekharan, J. L. Gommerman, A. Prat, S. Fillatreau, A. Bar-Or, and Canadian B Cells in MS Team. 2015. Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy. Science Translational Medicine 7(310):310ra166.
Loane, D. J., and K. R. Byrnes. 2010. Role of microglia in neurotrauma. Neurotherapeutics 7(4):366-377.
Macosko, E. Z., A. Basu, R. Satija, J. Nemesh, K. Shekhar, M. Goldman, I. Tirosh, A. R. Bialas, N. Kamitaki, E. M. Martersteck, J. J. Trombetta, D. A. Weitz, J. R. Sanes, A. K. Shalek, A. Regev, and S. A. McCarroll. 2015. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161(5):1202-1214.
Magliozzi, R., O. W. Howell, C. Reeves, F. Roncaroli, R. Nicholas, B. Serafini, F. Aloisi, and R. Reynolds. 2010. A gradient of neuronal loss and meningeal inflammation in multiple sclerosis. Annals of Neurology 68(4):477-493.
Marik, C., P. A. Felts, J. Bauer, H. Lassmann, and K. J. Smith. 2007. Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity? Brain 130(Pt 11):2800-2815.
McIntyre, R. S., D. S. Cha, J. M. Jerrell, W. Swardfager, R. D. Kim, L. G. Costa, A. Baskaran, J. K. Soczynska, H. O. Woldeyohannes, R. B. Mansur, E. Brietzke, A. M. Powell, A. Gallaugher, P. Kudlow, O. Kaidanovich-Beilin, and M. Alsuwaidan. 2014. Advancing biomarker research: Utilizing “big data” approaches for the characterization and prevention of bipolar disorder. International Journal of Bipolar Disorders 16(5):531-547.
Miller, A. H., and C. L. Raison. 2016. The role of inflammation in depression: From evolutionary imperative to modern treatment target. Nature Reviews Immunology 16(1):22-34.
Mouzon, B., H. Chaytow, G. Crynen, C. Bachmeier, J. Stewart, M. Mullan, W. Stewart, and F. Crawford. 2012. Repetitive mild traumatic brain injury in a mouse model produces learning and memory deficits accompanied by histological changes. Journal of Neurotrauma 29(18):2761-2773.
Mouzon, B. C., C. Bachmeier, A. Ferro, J. O. Ojo, G. Crynen, C. M. Acker, P. Davies, M. Mullan, W. Stewart, and F. Crawford. 2014. Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model. Annals of Neurology 75(2):241-254.
Perrin, R. J., A. M. Fagan, and D. M. Holtzman. 2009. Multimodal techniques for diagnosis and prognosis of Alzheimer’s disease. Nature 461(7266):916-922.
Raison, C. L., R. E. Rutherford, B. J. Woolwine, C. Shuo, P. Schettler, D. F. Drake, E. Haroon, and A. H. Miller. 2013. A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: The role of baseline inflammatory biomarkers. JAMA Psychiatry 70(1):31-41.
Ryu, J. K., and J. G. McLarnon. 2009. A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain. Journal of Cellular and Molecular Medicine 13(9A):2911-2925.
Ryu, J. K., M. A. Petersen, S. G. Murray, K. M. Baeten, A. Meyer-Franke, J. P. Chan, E. Vagena, C. Bedard, M. R. Machado, P. E. Rios Coronado, T. Prod’homme, I. F. Charo, H. Lassmann, J. L. Degen, S. S. Zamvil, and K. Akassoglou. 2015. Blood coagulation protein fibrinogen promotes
autoimmunity and demyelination via chemokine release and antigen presentation. Nature Communications 6:8164.
Schachtrup, C., J. K. Ryu, M. J. Helmrick, E. Vagena, D. K. Galanakis, J. L. Degen, R. U. Margolis, and K. Akassoglou. 2010. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage. Journal of Neuroscience 30(17):5843-5854.
Sekar, A., A. R. Bialas, H. de Rivera, A. Davis, T. R. Hammond, N. Kamitaki, K. Tooley, J. Presumey, M. Baum, V. Van Doren, G. Genovese, S. A. Rose, R. E. Handsaker, Schizophrenia Working Group of the Psychiatric Genomics Consortium, M. J. Daly, M. C. Carroll, B. Stevens, and S. A. McCarroll. 2016. Schizophrenia risk from complex variation of complement component 4. Nature 530(7589):177-183.
Setiawan, E., A. A. Wilson, R. Mizrahi, P. M. Rusjan, L. Miler, G. Rajkowska, I. Suridjan, J. L. Kennedy, P. V. Rekkas, S. Houle, and J. H. Meyer. 2015. Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes. JAMA Psychiatry 72(3):268-275.
Sieweke, M. H., and J. E. Allen. 2013. Beyond stem cells: Self-renewal of differentiated macrophages. Science 342(6161):1242974.
Streit, W. J., N. W. Sammons, A. J. Kuhns, and D. L. Sparks. 2004. Dystrophic microglia in the aging human brain. Glia 45(2):208-212.
Suarez-Calvet, M., M. A. Araque Caballero, G. Kleinberger, R. J. Bateman, A. M. Fagan, J. C. Morris, J. Levin, A. Danek, M. Ewers, C. Haass, and Dominantly Inherited Alzheimer Network. 2016. Early changes in CSF STREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury. Science Translational Medicine 8(369):369ra178.
Tracey, K. J. 2002. The inflammatory reflex. Nature 420(6917):853-859.
Vos, C. M., J. J. Geurts, L. Montagne, E. S. van Haastert, L. Bo, P. van der Valk, F. Barkhof, and H. E. de Vries. 2005. Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis. Neurobiology of Disease 20(3):953-960.
Zhong, L., X. F. Chen, T. Wang, Z. Wang, C. Liao, Z. Wang, R. Huang, D. Wang, X. Li, L. Wu, L. Jia, H. Zheng, M. Painter, Y. Atagi, C. C. Liu, Y. W. Zhang, J. D. Fryer, H. Xu, and G. Bu. 2017. Soluble TREM2 induces inflammatory responses and enhances microglial survival. Journal of Experimental Medicine 214(3):597-607.