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F Disclosure of Conflicts of Interest The conflict-of-interest policy of the National Academies of Sciences, Engineering, and Medicine (www.nationalacademies.org/coi) prohibits the appointment of an individual to a committee like the one that authored this Consensus Study Report if the individual has a conflict of interest that is relevant to the task to be performed. An exception to this prohibition is permitted only if the National Academies determine that the conflict is unavoidable and the conflict is promptly and publicly disclosed. When the committee that authored this report was established a determination of whether there was a conflict of interest was made for each committee member given the individualâs circumstances and the task being undertaken by the committee. A determination that an individual has a conflict of interest is not an assessment of that individualâs actual behavior or character or ability to act objectively despite the conflicting interest. Dr. Michael Rosenblatt was determined to have a conflict of interest because he is the chief medical officer for Flagship Pioneering and is a shareholder of Radius (of which he is a founder) and Merck & Co., Inc. Mr. Henri Termeer was determined to have a conflict of interest because he was former chairman, president, and chief executive officer of Genzyme Corporation and also served on the boards of directors for several pharmaceutical and biotech companies. Dr. Reed Tuckson was determined to have a conflict of interest because he is a former executive vice president and chief of medical affairs for the UnitedHealth Group. In each case, the National Academies determined that the experience and expertise of the individual was needed for the committee to accomplish the task for which it was established. The National Academies could not find another available individual with the equivalent experience and expertise who did not have a conflict of interest. Therefore, the National Academies concluded that the conflict was unavoidable and publicly disclosed it through the National Academies Current Projects System (www.nationalacademies.org/cp). PREPUBLICATION COPY: UNCORRECTED PROOFS 189