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Section I E-Cigarette Devices, Constituents, and Exposures E-cigarette aerosol contains fewer numbers and lower levels of toxicants than smoke from combustible cigarettes. Nicotine exposure can mimic that found with use of combustible cigarettes, but is highly variable. However, exposure to nicotine and toxicants from the aerosolization of flavorings and humectants is dependent on user and device characteristics. 3 E-CIGARETTE DEVICES, USES, AND EXPOSURES 4 NICOTINE 5 TOXICOLOGY OF E-CIGARETTE CONSTITUENTS 6 RESEARCH NEEDS: E-CIGARETTE DEVICES, CONSTITUENTS, AND EXPOSURES PREPUBLICATION COPY: UNCORRECTED PROOF