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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
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Advancing Disease Modeling
in Animal-Based Research in
Support of Precision Medicine

PROCEEDINGS OF A WORKSHOP

Erin Hammers Forstag and Lida Anestidou, Rapporteurs

Roundtable on Science and Welfare in Laboratory Animal Use

Institute for Laboratory Animal Research

Division on Earth and Life Studies

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THE NATIONAL ACADEMIES PRESS
Washington, DC
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
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THE NATIONAL ACADEMIES PRESS 500 Fifth Street, NW Washington, DC 20001

This project was supported by the American Veterinary Medical Association; Baylor College of Medicine; Emory University; Genentech; GlaxoSmithKline; Indiana University; Johns Hopkins University; Johnson & Johnson; Massachusetts General Hospital; Massachusetts Institute of Technology; Medical College of Wisconsin; Merck and Co., Inc.; National Institutes of Health (Contract No. HHSN263201200074I; Task Order HHSN26300122); National Primate Research Centers; Novartis; University of California, Davis; University of Miami; University of Michigan; University of Pittsburgh; and Yale University. Funding for this conference was made possible, in part, by the U.S. Food and Drug Administration through grant 5 R13 FD 005298-02. Views expressed in written conference materials or publications and by speakers or moderators do not necessarily reflect the official policies of the U.S. Department of Health and Human Services; nor does any mention of trade names, commercial practices, or organizations imply endorsement by the U.S. government. This material is based on work supported by the National Science Foundation under Grant No. IOS-1639899. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project.

International Standard Book Number-13: 978-0-309-47116-9
International Standard Book Number-10: 0-309-47116-8
Digital Object Identifier: https://doi.org/10.17226/25002

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Suggested citation: National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: https://doi.org/10.17226/25002.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×

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The National Academy of Sciences was established in 1863 by an Act of Congress, signed by President Lincoln, as a private, nongovernmental institution to advise the nation on issues related to science and technology. Members are elected by their peers for outstanding contributions to research. Dr. Marcia McNutt is president.

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Learn more about the National Academies of Sciences, Engineering, and Medicine at www.nationalacademies.org.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×

images

Consensus Study Reports published by the National Academies of Sciences, Engineering, and Medicine document the evidence-based consensus on the study’s statement of task by an authoring committee of experts. Reports typically include findings, conclusions, and recommendations based on information gathered by the committee and the committee’s deliberations. Each report has been subjected to a rigorous and independent peer-review process and it represents the position of the National Academies on the statement of task.

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For information about other products and activities of the National Academies, please visit www.nationalacademies.org/about/whatwedo.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×

PLANNING COMMITTEE ON ADVANCING DISEASE MODELING IN ANIMAL-BASED RESEARCH IN SUPPORT OF PRECISION MEDICINE: A WORKSHOP

Members

Brian R. Berridge, GlaxoSmithKline (Co-Chair)

K.C. Kent Lloyd, University of California, Davis (Co-Chair)

Cory Brayton, Johns Hopkins University

Robert M. Califf, Duke University School of Medicine

Melissa Haendel, Oregon Health & Science University

John P.A. Ioannidis, Stanford University

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
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ROUNDTABLE ON SCIENCE AND WELFARE IN LABORATORY ANIMAL USE

Co-Chairs

Robert C. Dysko, University of Michigan Medical School

K.C. Kent Lloyd, University of California, Davis

Liaison to ILAR Council

Paul A. Locke, Johns Hopkins Bloomberg School of Public Health

Members

Jill Ascher, U.S. Food and Drug Administration

Szczepan Baran, Novartis Institutes for Biomedical Research, Inc.

Bonnie V. Beaver, Texas A&M University

Cindy Buckmaster, Baylor College of Medicine

Saverio (Buddy) Capuano III, University of Wisconsin–Madison

Carol Clarke, U.S. Department of Agriculture

Michael DuVall, Janssen Pharmaceuticals

James G. Fox, Massachusetts Institute of Technology

Alema Galijatovic-Idrizbegovic, Merck & Co., Inc.

Gail C. Golab, American Veterinary Medical Association

Debra L. Hickman, Indiana University School of Medicine

Michael Huerkamp, Emory University

Donna Matthews Jarrell, Massachusetts General Hospital

Bruce W. Kennedy, Chapman University

David M. Kurtz, National Institute of Environmental Health Sciences

Margaret S. Landi, GlaxoSmithKline

Joseph T. Newsome, University of Pittsburgh

Patricia Preisig, Yale University

Edda (Floh) Thiels, National Science Foundation

Joseph Thulin, Medical College of Wisconsin

Rhonda J. Wiler, Genentech

Axel Wolff, National Institutes of Health

Robert H. Wurtz, National Institutes of Health

Julia Zaias, University of Miami

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×

Staff

Lida Anestidou, Director, Roundtable on Science and Welfare in Laboratory Animal Use

Angela Kolesnikova, Senior Program Assistant, Board on Life Sciences

Jenna Ogilvie, Research Associate, Board on Life Sciences (until November 27, 2017)

Consultant

Erin Hammers Forstag, Writer

Page viii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
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INSTITUTE FOR LABORATORY ANIMAL RESEARCH

Members

Margaret S. Landi, Chief of Animal Welfare, Ethics and Strategy, GlaxoSmithKline (Chair)

Karin Blumer, Scientific Affairs, Novartis International AG

Cory Brayton, Associate Professor of Molecular and Comparative Pathobiology, Johns Hopkins University

Joseph J. DeGeorge, Global Head of Safety Assessment and Laboratory Animal Resources, Merck Research Laboratories

Michael DuVall, Scientific Director, Head of Toxicology and Laboratory Animal Medicine, Johnson and Johnson, Janssen Pharmaceuticals

Lewis B. Kinter, Independent Consultant

Paul A. Locke, Associate Professor, Department of Environmental Health and Engineering Director, DrPH Program in Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health

Daniel S. Marsman, Head, Safety and Regulatory Affairs, Procter & Gamble Health Care

Melinda A. Novak, Professor of Psychology, University of Massachusetts

James A. Roth, Clarence Hartley Covault Distinguished Professor, Director, Center for Food Security and Public Health, College of Veterinary Medicine, Iowa State University

Lawrence B. Schook, Edward William and Jane Marr Gutsgell Professor of Animal Sciences and Radiology, University of Illinois at Urbana-Champaign

Robert S. Sikes, Professor of Biology, University of Arkansas at Little Rock

Staff

Gregory Symmes, Interim Director (from November 1, 2017)

Dorothy Zolandz, Interim Director (until October 31, 2017)

Lida Anestidou, Senior Program Officer

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×

Acknowledgments

This Proceedings of a Workshop was reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise. The purpose of this independent review is to provide candid and critical comments that will assist the National Academies of Sciences, Engineering, and Medicine in making each published proceedings as sound as possible and to ensure that it meets the institutional standards for quality, objectivity, evidence, and responsiveness to the charge. The review comments and draft manuscript remain confidential to protect the integrity of the process.

We thank the following individuals for their review of this proceedings:

Mary E. Dickinson, Baylor College of Medicine

Alema Galijatovic-Idrizbegovic, Merck & Co., Inc.

Charles L. Sawyers, Memorial Sloan Kettering Cancer Center

Joe V. Selby, Patient-Centered Outcomes Research Institute

Although the reviewers listed above provided many constructive comments and suggestions, they were not asked to endorse the content of the proceedings nor did they see the final draft before its release. The review of this proceedings was overseen by Huda Akil, University of Michigan Medical School. She was responsible for making certain that an independent examination of this proceedings was carried out in accordance with standards of the National Academies and that all review comments were carefully considered. Responsibility for the final content rests entirely with the rapporteurs and the National Academies.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×

The support of the Roundtable on Science and Welfare in Laboratory Animal Use was vital to the planning and conduct of the workshop on Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine. Federal sponsors are the National Institutes of Health, the National Science Foundation, and the U.S. Food and Drug Administration. Nonfederal sponsorship was provided by the American Veterinary Medical Association; Baylor College of Medicine; Emory University; Genentech; GlaxoSmithKline; Indiana University; Johns Hopkins University; Johnson & Johnson; Massachusetts General Hospital; Massachusetts Institute of Technology; Medical College of Wisconsin; Merck and Co., Inc.; National Primate Research Centers; Novartis; University of California, Davis; University of Miami; University of Michigan; University of Pittsburgh; and Yale University.

The Roundtable on Science and Welfare in Laboratory Animal Use expresses deep gratitude to the members of the planning committee for developing an expansive and multifaceted workshop agenda and to the expert speakers who took part in the workshop’s discussions.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×

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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×
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Page viii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×
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Page xiii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25002.
×
Page R14
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Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop.

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