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Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Examining Special Nutritional Requirements in Disease States: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25164.
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Appendix A

Workshop Agenda

Examining Special Nutritional Requirements in Disease States:
A Workshop

Planning Committee on Examining
Special Nutritional Requirements in Disease States

April 23, 2018
National Academy of Sciences Building
Lecture Room
2101 Constitution Avenue, NW
Washington, DC

Workshop Objectives
  • Examine pathophysiological mechanisms by which specific diseases impact nutrient metabolism and nutrition status and whether this impact would result in nutrient requirements that differ from the Dietary Reference Intakes.
    • Explore the role of genetic variation in nutrition requirements.
    • Examine nutrient requirements in certain chronic conditions or acute phases for which emerging data suggest a contribution of nutrition status to disease outcomes. Consider the scientific evidence needed to establish such relationships and discuss principles about the relationship between nutrition requirements and specific diseases.
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Examining Special Nutritional Requirements in Disease States: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25164.
×
    • Explore how a disease state impacts nutrient metabolism and nutritional status and, conversely, how nutritional status impacts the disease state.
  • Identify promising approaches and challenges to establishing a framework for determining special nutrient requirements related to managing disease states.

WORKSHOP DAY 1: APRIL 2, 2018, 8:30 AM–5:15 PM

7:30–8:30 AM Registration
Session 1: Introduction of the Concepts and Context of the Workshop
Moderator: Barbara Schneeman, University of California, Davis
8:30 Origins of the Workshop
Barbara Schneeman, University of California, Davis, Planning Committee Chair
8:50 What Defines a Special Nutritional Requirement?
Patsy Brannon, Cornell University
9:10 The Underlying Biological Processes of Special Nutritional Requirements
Patrick Stover, Texas A&M AgriLife
9:30 Moderated Panel Discussion and Q&A
10:00 Break
Session 2: Addressing Nutrient Needs Due to Loss of Function in Genetic Diseases
Moderator: Erin MacLeod, Children’s National Health System
10:20 Understanding the Basis of Nutritional Needs in Phenylketonuria
Denise Ney, University of WisconsinMadison
10:40 Nutritional Inadequacies in Mitochondrial-Associated Metabolic Disorders
Marni Falk, Children’s Hospital of Philadelphia (via Zoom)
11:00 Contribution of Nutrients in Complex Inborn Errors of Metabolism: The Case of Methylmalonic Acidemia (MMA)
Charles Venditti, National Human Genome Research Institute, National Institutes of Health
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Examining Special Nutritional Requirements in Disease States: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25164.
×
11:20 Lessons Learned: What We Know About Nutrition Management for Inborn Errors of Metabolism
Sue Berry, University of Minnesota
11:40 Moderated Panel Discussion and Q&A
12:00–1:00 PM Lunch
Session 3: Disease-Induced Loss of Function and Tissue Regeneration
Moderator: Alex Kemper, Nationwide Children’s Hospital
1:00 Examples of Gastrointestinal Dysfunction and Malabsorption of Nutrients: Intestinal Failure
Chris Duggan, Boston Children’s Hospital (via Zoom)
1:30 Examples of Gastrointestinal Dysfunction and Malabsorption of Nutrients: Cystic Fibrosis
Sarah Jane Schwarzenberg, University of Minnesota Masonic Children’s Hospital
1:50 Nutritional Requirements for Inflammatory Bowel Disease
Dale Lee, Seattle Children’s Hospital
2:10 Blood–Brain Barrier Dysfunction and Resulting Brain Nutrient Deficiencies
Martha Field, Cornell University
2:30 Macro- and Micronutrient Homeostasis in the Setting of Chronic Kidney Disease
Alp Ikizler, Vanderbilt University
2:50 Moderated Panel Discussion and Q&A
3:15 Break
Session 4: Disease-Induced Deficiency and Conditionally Essential Nutrients in Disease
Moderator: Bernadette Marriott, Medical University of South Carolina
3:30 Arginine as an Example of a Conditionally Essential Nutrient: Sickle Cell Anemia and Surgery
Claudia Morris, Emory University School of Medicine
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Examining Special Nutritional Requirements in Disease States: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25164.
×
3:50 Nutritional Needs in Hypermetabolic States: Burns, Cachexia, and Surgery
Paul Wischmeyer, Duke University School of Medicine [NOTE: He did not speak at the workshop.]
4:10 Traumatic Brain Injury: Pathophysiological Mechanisms and Potential Nutrient Needs
Angus Scrimgeour, U.S. Army Research Institute of Environmental Medicine
4:30 Metabolic Turnover, Inflammation, and Redistribution: Impact on Nutrient Requirements
Jesse Gregory, University of Florida
4:50 Moderated Panel Discussion and Q&A
5:15 Adjourn First Day

WORKSHOP DAY 2: APRIL 3, 2018, 8:30 AM–1:00 PM

7:30–8:30 AM Registration
Session 5: Building the Evidence Base: Research Approaches for Nutrients in Disease States
Moderator: Alex Kemper, Nationwide Children’s Hospital
8:30 Type and Strength of Evidence Needed for Determining Special Nutrient Requirements
Amanda MacFarlane, Health Canada
8:50 Identification and Validation of Biomarkers in Disease States
Patrick Stover, Texas A&M AgriLife
9:10 Innovative Causal Designs for Efficacy: What Type of Evidence Is Needed?
Nicholas Schork, J. Craig Venter Institute
9:30 Examples of a Complex Disease
  • Inflammatory Bowel Disease
    Gary Wu, University of Pennsylvania
  • Cancer
Steve Clinton, The Ohio State University
10:15 Moderated Panel Discussion and Q&A
10:45 Break
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Examining Special Nutritional Requirements in Disease States: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25164.
×
Session 6: Future Opportunities
Moderator: Barbara Schneeman, University of California, Davis
11:00 Principles Learned from Workshop Presentations
Barbara Schneeman, University of California, Davis
11:20 Panel Discussion
Susan Barr, University of British Columbia
Kristen D’Anci, ECRI Institute
(via Zoom)
Tim Morck, Spectrum Nutrition LLC
Virginia A. Stallings, Children’s Hospital of Philadelphia
12:30 PM Sponsor Remarks
Paul Coates, National Institutes of Health
Patricia Hansen, U.S. Food and Drug Administration
Caren Heller, Crohn’s & Colitis Foundation
Chantal Martineau, Health Canada
Sarah Ohlhorst, American Society for Nutrition
Alison Steiber, Academy of Nutrition and Dietetics
1:00 Meeting Adjourned
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Examining Special Nutritional Requirements in Disease States: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25164.
×

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Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Examining Special Nutritional Requirements in Disease States: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25164.
×
Page 113
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Examining Special Nutritional Requirements in Disease States: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25164.
×
Page 114
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Examining Special Nutritional Requirements in Disease States: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25164.
×
Page 115
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Examining Special Nutritional Requirements in Disease States: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25164.
×
Page 116
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Examining Special Nutritional Requirements in Disease States: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25164.
×
Page 117
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Examining Special Nutritional Requirements in Disease States: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25164.
×
Page 118
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The amount of nutrients required by an individual is determined by a number of physiological processes, including absorption, metabolism, stability, and bio-activation. These processes determine nutrient needs and provide variations in requirements in the population. All have modifiers and sensitizers, such as sex, genetics, pregnancy, age, pharmaceuticals, toxins, food matrix, and epigenetics. Disease can also be a major modifier of these processes. In April 2018, the National Academies of Science, Engineering and Medicine convened a workshop in order to explore the evidence for special nutritional requirements in disease states and the medical conditions that cannot be met with a normal diet. Participants explored the impact a disease state can have on nutrient metabolism and nutritional status, and attempted to close informational gaps. This publication summarizes the presentations and discussions from the workshop.

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