A Class Approach to Hazard
Assessment of Organohalogen
Committee to Develop a Scoping Plan to Assess the Hazards of
Organohalogen Flame Retardants
Board on Environmental Studies and Toxicology
Division on Earth and Life Studies
A Consensus Study Report of
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International Standard Book Number-13: 978-0-309-49118-1
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Digital Object Identifier: https://doi.org/10.17226/25412
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Suggested Citation: National Academies of Sciences, Engineering, and Medicine. 2019. A Class Approach to Hazard Assessment of Organohalogen Flame Retardants. Washington, DC: The National Academies Press. doi: https://doi.org/10.17226/25412.
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COMMITTEE TO DEVELOP A SCOPING PLAN TO ASSESS THE HAZARDS OF ORGANOHALOGEN FLAME RETARDANTS
DAVID C. DORMAN (Chair), North Carolina State University, Raleigh, NC
HUGH A. BARTON (retired), Pfizer, Groton, CT
KAREN BLACKBURN, Procter & Gamble Company, Cincinnati, OH
JOHN BUCHER, National Institute of Environmental Health Sciences, Durham, NC
JULIE L. DANIELS, University of North Carolina at Chapel Hill, Chapel Hill, NC
JENNIFER L. FREEMAN, Purdue University, West Lafayette, IN
KAMEL MANSOURI, Integrated Laboratory Systems, Raleigh, NC
CARMEN MESSERLIAN, Harvard T.H. Chan School of Public Health, Boston, MA
DAVID M. REIF, North Carolina State University, Raleigh, NC
GINA M. SOLOMON, Public Health Institute, Oakland, CA
CHIHAE YANG, Molecular Networks GMbH, Columbus, OH
ELLEN K. MANTUS, Project Director
SUSAN N.J. MARTEL, Senior Program Officer
RADIAH ROSE-CRAWFORD, Manager, Editorial Projects
JESSICA WOLFMAN, Senior Program Assistant
US CONSUMER PRODUCT SAFETY COMMISSION
BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY
WILLIAM H. FARLAND (Chair), Colorado State University, Fort Collins, CO
LESA AYLWARD, Summit Toxicology, LLP, Falls Church, VA
ANN M. BARTUSKA, Resources for the Future, Washington, DC
RICHARD A. BECKER, American Chemistry Council, Washington, DC
E. WILLIAM COLGLAZIER, American Association for the Advancement of Science, Washington, DC
DOMINIC M. DITORO, University of Delaware, Newark, DE
DAVID C. DORMAN, North Carolina State University, Raleigh, NC
GEORGE GRAY, George Washington University, Washington, DC
R. JEFFREY LEWIS, ExxonMobil Biomedical Sciences, Inc., Annandale, NJ
GERMAINE M. BUCK LOUIS, George Mason University, Fairfax, VA
ROBERT PERCIASEPE, Center for Climate and Energy Solutions, Arlington, VA
REZA J. RASOULPOUR, Dow AgroSciences, Indianapolis, IN
JOAN B. ROSE, Michigan State University, East Lansing, MI
GINA M. SOLOMON, Public Health Institute, Oakland, CA
DEBORAH L. SWACKHAMER, University of Minnesota, St. Paul, MN
JOSHUA TEWKSBURY, Future Earth, Boulder, CO
PETER S. THORNE, University of Iowa, Iowa City, IA
CLIFFORD DUKE, Director
ELLEN K. MANTUS, Scholar and Director of Risk Assessment
RAYMOND A. WASSEL, Scholar and Director of Environmental Studies
SUSAN N.J. MARTEL, Senior Program Officer for Toxicology
LAURA LLANOS, Financial Associate
TAMARA DAWSON, Program Associate
This Consensus Study Report was reviewed in draft form by persons chosen for their diverse perspectives and technical expertise. The purpose of this independent review is to provide candid and critical comments that will assist the National Academies of Sciences, Engineering, and Medicine in making each published report as sound as possible and to ensure that it meets institutional standards of quality, objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process.
We thank the following for their review of this report:
Vinicius Alves, University of North Carolina, Chapel Hill
Joseph Braun, Brown University
Weisueh Chiu, Texas A&M University
Nigel Greene, AstraZeneca
Richard Judson, US Environmental Protection Agency
Andres Kortenkamp, Brunel University, London
Eugene Muratov, University of North Carolina, Chapel Hill
Reza Rasoulpour, Dow AgroSciences
Heather Stapleton, Duke University
David Volz, University of California, Riverside
Although the reviewers listed above provided many constructive comments and suggestions, they were not asked to endorse the conclusions or recommendations of this report, nor did they see the final draft before its release. The review of the report was overseen by David Allison, Indiana University, and Joseph Rodricks, Ram-boll Environ, who were responsible for making certain that an independent examination of the report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content rests entirely with the authoring committee and the National Academies.
The committee gratefully acknowledges the staff of the US Consumer Product Safety Commission for their presentations to the committee during open sessions. The committee is also grateful for the assistance of Norman Grossblatt who served as the report editor.
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BOXES, FIGURES, AND TABLES
B-1 Standardization of structures to provide QSAR-ready structures amenable to modeling: desalted, stereochemistry-stripped, tautomers and nitro groups standardized, valence corrected, structures neutralized when possible, and duplicates removed, among other steps