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ACKNOWLEDGMENT OF REVIEWERS This report was reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their review of this report: Sonia Abdelhak, The Pasteur Institute of Tunis (Tunisia) Ruth Chadwick, Cardiff University (United Kingdom) Pat Clarke, European Disability Forum (European Union) Bernd GÃ¤nsbacher, Technical University of Munich (Germany) Mohammed Ghaly, Hamad Bin Khalifa University (Qatar) Mary Herbert, Newcastle University (United Kingdom) Rudolf Jaenisch, Massachusetts Institute of Technology (USA) Kazuto Kato, Osaka University (Japan) Tim Lewens, University of Cambridge (United Kingdom) John Lim, Duke University-National University of Singapore (Singapore) David Liu Massachusetts Institute of Technology and Harvard University (USA) Dennis Lo, The Chinese University of Hong Kong (Hong Kong) Robin Lovell-Badge, The Francis Crick Institute (United Kingdom) Luigi Naldini, Vita-Salute San Raffaele University (Italy) Kathy Niakan, The Francis Crick Institute (United Kingdom) Kelly Ormond, Stanford University (USA) Sharon Terry, Genetic Alliance (USA) Although the reviewers listed above provided many constructive comments and suggestions, they were not asked to endorse the conclusions or recommendations, nor did they see the final draft of the report before its release. The review of this report was overseen by Suzanne Cory, University of Melbourne (Australia), and Janet Rossant, The Gairdner Foundation (Canada). Acting on behalf of the studyâs International Oversight Board, They were responsible for making certain that an independent examination of this report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this report rests entirely with the authoring Commission and the institutions. PREPUBLICATION COPY | UNCORRECTED PROOFS 211