National Academies Press: OpenBook

Heritable Human Genome Editing (2020)

Chapter: Acknowledgment of Reviewers

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Suggested Citation:"Acknowledgment of Reviewers." National Academy of Medicine, National Academy of Sciences, and the Royal Society. 2020. Heritable Human Genome Editing. Washington, DC: The National Academies Press. doi: 10.17226/25665.
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Page 211

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ACKNOWLEDGMENT OF REVIEWERS This report was reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their review of this report: Sonia Abdelhak, The Pasteur Institute of Tunis (Tunisia) Ruth Chadwick, Cardiff University (United Kingdom) Pat Clarke, European Disability Forum (European Union) Bernd Gänsbacher, Technical University of Munich (Germany) Mohammed Ghaly, Hamad Bin Khalifa University (Qatar) Mary Herbert, Newcastle University (United Kingdom) Rudolf Jaenisch, Massachusetts Institute of Technology (USA) Kazuto Kato, Osaka University (Japan) Tim Lewens, University of Cambridge (United Kingdom) John Lim, Duke University-National University of Singapore (Singapore) David Liu Massachusetts Institute of Technology and Harvard University (USA) Dennis Lo, The Chinese University of Hong Kong (Hong Kong) Robin Lovell-Badge, The Francis Crick Institute (United Kingdom) Luigi Naldini, Vita-Salute San Raffaele University (Italy) Kathy Niakan, The Francis Crick Institute (United Kingdom) Kelly Ormond, Stanford University (USA) Sharon Terry, Genetic Alliance (USA) Although the reviewers listed above provided many constructive comments and suggestions, they were not asked to endorse the conclusions or recommendations, nor did they see the final draft of the report before its release. The review of this report was overseen by Suzanne Cory, University of Melbourne (Australia), and Janet Rossant, The Gairdner Foundation (Canada). Acting on behalf of the study’s International Oversight Board, They were responsible for making certain that an independent examination of this report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this report rests entirely with the authoring Commission and the institutions. PREPUBLICATION COPY | UNCORRECTED PROOFS 211

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Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing.

From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

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