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Next Steps for Functional Genomics: Proceedings of a Workshop (2020)

Chapter: Appendix B: Workshop Agenda

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Suggested Citation:"Appendix B: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2020. Next Steps for Functional Genomics: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25780.
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Page 123
Suggested Citation:"Appendix B: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2020. Next Steps for Functional Genomics: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25780.
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Page 124
Suggested Citation:"Appendix B: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2020. Next Steps for Functional Genomics: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25780.
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Page 125

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  Appendix B Workshop Agenda Next Steps for Functional Genomics: A Workshop February 10-12, 2020 National Academy of Sciences, Room 120 2101 Constitution Avenue, NW, Washington, DC 20418 DAY 1: MONDAY, FEBRUARY 10 8:45 Welcome and Opening Remarks Steven Moss, National Academies of Sciences, Engineering, and Medicine Donal Manahan, National Science Foundation Gene Robinson, University of Illinois at Urbana-Champaign, Chair of the Steering Committee 9:00 Keynote Speaker Introduced by Gene Robinson, University of Illinois at Urbana-Champaign Title: Design for Inference in Biology Aviv Regev, Broad Institute and Massachusetts Institute of Technology 10:00-10:15 Coffee Break 10:15 Talks and Facilitated Panel Discussion: Case Studies on Building Functional Genomics Tools in Diverse Systems 15-minute talks from each person followed by panel guided questions and discussion Moderator: Lauren O’Connell, Stanford University Andrea Sweigart, University of Georgia Rachel Dutton, University of California, San Diego Zoe Donaldson, University of Colorado Boulder Dominique Bergmann, Stanford University Steven Henikoff, Fred Hutchinson Cancer Research Center 12:00-1:00 Lunch 1:00 Facilitated Panel Discussion: Determining and Defining “Model” Systems for Diverse Functional Genomics Applications 10-minute introduction to topic from Paul Katz followed by a facilitated discussion Moderator: Andrea Sweigart, University of Georgia Paul Katz, University of Massachusetts Amherst Lauren O’Connell, Stanford University Zoe Donaldson, University of Colorado Boulder Dominique Bergmann, Stanford University 2:15 Talks and Facilitated Panel Discussion: Understanding the Contributions of the Non-Protein- Coding DNA to Phenotype 15-minute talks from each person followed by panel-guided questions and discussion Moderator: Terry Magnuson, University of North Carolina at Chapel Hill Felicity Jones, Friedrich Miescher Laboratory of the Max Planck Society Scott Edwards, Harvard University Francois Spitz, University of Chicago Prepublication Copy 123

Next Steps for Functional Genomics 3:45-4:00 Coffee/Snack Break 4:00 Facilitated Panel Discussion: Societal and Ethical Implications of Functional Genomics Research 5 minutes of opening comments by each panelist, followed by a facilitated discussion Moderator: Zoe Donaldson, University of Colorado Boulder Rebecca Walker, University of North Carolina at Chapel Hill Scott Jackson, Bayer Crop Science Ronald Sandler, Northeastern University 5:00 Closing Remarks Philip Benfey, Duke University 5:00 Adjourn DAY 2: TUESDAY, FEBRUARY 11 9:00 Keynote Speaker Introduced by Trudy MacKay, Clemson University Title: Predicting Current and Future Sources of Variation in Quantitative Traits Patricia Wittkopp, University of Michigan 10:00-10:15 Coffee Break 10:15 Talks and Facilitated Panel Discussion: Advancement of Research on Environmental Regulation of Gene Function 15-minute talks from each person followed by panel-guided questions and discussion Moderator: Philip Benfey, Duke University Sarah Kocher, Princeton University Joanna Kelley, Washington State University Nathan Springer, University of Minnesota Trudy MacKay, Clemson University 12:00-1:00 Lunch 1:00 Talks and Facilitated Panel Discussion: Challenges and Successes of Integrating Large Datasets 15-minute talks from each person followed by panel-guided questions and discussion Moderator: Norbert Tavares, Chan Zuckerberg Initiative Alexis Battle, Johns Hopkins University Saurabh Sinha, University of Illinois at Urbana-Champaign Rahul Satija, New York Genome Center Charles Danko, Cornell University Genevieve Haliburton, Chan Zuckerberg Initiative 2:20 Facilitated Panel Discussion: Pros and Cons of Consortia and Large Databases 2-3 minutes of opening comments by each panelist, followed by a facilitated discussion Moderator: Charles Danko, Cornell University Felicity Jones, Friedrich Miescher Laboratory of the Max Planck Society Alexis Battle, Johns Hopkins University Saurabh Sinha, University of Illinois at Urbana-Champaign Rahul Satija, New York Genome Center Sean Hanlon, National Cancer Institute, National Institutes of Health 3:15-3:30 Coffee/Snack Break     124 Prepublication Copy

Appendix B  3:30 Interactive Session and Panel Discussion: Addressing Challenges in Education and Training Groups of 6-8 will discuss prompt questions from 3:15-3:45. Each group will have 3-5 minutes to summarize its main points. We will then move into a panel discussion. Moderator: Patricia Wittkopp, University of Michigan Terry Magnuson, University of North Carolina Chapel Hill Arnaud Martin, The George Washington University Lauren O’Connell, Stanford University Grace Anderson, Octant Rebecca Walker, University of North Carolina at Chapel Hill 5:00 Closing Remarks Emma Farley, University of California, San Diego 5:05 Adjourn DAY 3: WEDNESDAY, FEBRUARY 12 9:00 Talks and Facilitated Panel Discussion: Interpreting and Validating Results from High- Throughput Screening Approaches 15-minute talks from each person followed by panel-guided questions and discussion Moderator: Trudy MacKay, Clemson University David C. Page, Whitehead Institute Emma Farley, University of California, San Diego Philip Benfey, Duke University Grace Anderson, Octant Gary Churchill, The Jackson Laboratory 10:45 Interactive Session on the Future of Functional Genomics Research Goals Participants will get into groups of 6-8 to think about the prompt questions related to short- and medium-term research goals of functional genomics. These groups will discuss from 10:40-11:20, followed by 5 minutes of reporting from each group on the main points it came up with. This will end with a larger discussion by all attendees. Moderator: Emma Farley, University of California, San Diego 11:45 Future of Functional Genomics Town Hall This is a final opportunity for any attendee to emphasize a point they heard during the meeting or bring up something that has not been addressed. Possible prompt questions will be provided. Moderator: Gene Robinson, University of Illinois at Urbana-Champaign, Chair of the Steering Committee 12:25 Closing Remarks Gene Robinson, University of Illinois at Urbana-Champaign, Chair of the Steering Committee 12:30 Meeting Adjourn Prepublication Copy 125

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One of the holy grails in biology is the ability to predict functional characteristics from an organism’s genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism’s phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from “-omics” screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.

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