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Next Steps for Functional Genomics: Proceedings of a Workshop (2020)

Chapter: Appendix E: Acronyms and Abbreviations

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Suggested Citation:"Appendix E: Acronyms and Abbreviations." National Academies of Sciences, Engineering, and Medicine. 2020. Next Steps for Functional Genomics: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25780.
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Appendix E

Acronyms and Abbreviations

ATAC-seq assay for transposase-accessible chromatin using sequencing
Ca++ calcium ion
ChIP-seq chromatin immunoprecipitation sequencing
ChRO-seq chromatin run-on and sequencing
CITE-seq cellular indexing of transcriptomes and epitopes by sequencing
ConA Concanavalin A
COX cytochrome c oxidase
CRISPR clustered regularly interspaced short palindromic repeats
CUT&RUN cleavage under targets and release using nuclease
CUT&Tag cleavage under targets and tagmentation
CZI Chan Zuckerberg Initiative
DGRP Drosophila melanogaster Genetic Reference Panel
EDGE Enabling Discovery through GEnomic Tools
ENCODE Encyclopedia of DNA Elements
eQTL expression quantitative trait locus
FGF fibroblast growth factor
GFP green fluorescent protein
GO gene ontology
GTEx Genotype-Tissue Expression
Suggested Citation:"Appendix E: Acronyms and Abbreviations." National Academies of Sciences, Engineering, and Medicine. 2020. Next Steps for Functional Genomics: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25780.
×
GWAS genome-wide association study
GxE genotype-by-environment
HCA Human Cell Atlas
HTS high-throughput screening
IBD inflammatory bowel disease
ICDA International Common Disease Alliance
ILC innate lymphoid cell
LNCRNA long non-coding RNA
LPS lipopolysaccharide
MAPK mitogen-activated protein kinase
MNase micrococcal nuclease
mRNA messenger RNA
NIH National Institutes of Health
NSF National Science Foundation
pA-MNASE protein A-micrococcal nuclease
pQTL protein quantitative trait locus
qPCR quantitative polymerase chain reaction
QTL quantitative trait locus
RNA-seq RNA-sequencing
SHR shortroot
shRNA short-hairpin RNA
SNP single nucleotide polymorphism
SQR sulfide-quinone reductase
STARmap spatially-resolved transcript amplicon readout mapping
TAD topologically associated domain
TF transcription factor
UIUC University of Illinois at Urbana-Champaign
V1aR vasopressin receptor 1a
WT wild-type
Suggested Citation:"Appendix E: Acronyms and Abbreviations." National Academies of Sciences, Engineering, and Medicine. 2020. Next Steps for Functional Genomics: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25780.
×
Page 185
Suggested Citation:"Appendix E: Acronyms and Abbreviations." National Academies of Sciences, Engineering, and Medicine. 2020. Next Steps for Functional Genomics: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25780.
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One of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.

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