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Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2020. Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25937.
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Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2020. Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25937.
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Page 58
Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2020. Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25937.
×
Page 59
Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2020. Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25937.
×
Page 60
Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2020. Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25937.
×
Page 61
Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2020. Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25937.
×
Page 62
Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2020. Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25937.
×
Page 63
Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2020. Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25937.
×
Page 64
Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2020. Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25937.
×
Page 65
Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2020. Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25937.
×
Page 66

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A References Abreu, C. M., L. Gama, S. Krasemann, M. Chesnut, S. Odwin-Dacosta, H. T. Hogberg, T. Hartung, and D. Pamies. 2018. Microglia increase inflammatory responses in iPSC- derived human brainspheres. Frontiers in Microbiology 9:2766. https://doi.org/10.3389/ fmicb.2018.02766. Al-Chalabi, A., and O. Hardiman. 2013. The epidemiology of ALS: A conspiracy of genes, en- vironment and time. Nature Reviews Neurology 9(11):617–628. https://doi.org/10.1038/ nrneurol.2013.203. Aylward, L. L., S. M. Hays, C. R. Kirman, S. A. Marchitti, J. F. Kenneke, C. English, D. R. Mattison, and R. A. Becker. 2014. Relationships of chemical concentrations in maternal and cord blood: A review of available data. Journal of Toxicology and Environmental Health. Part B, Critical Reviews 17(3):175–203. https://doi.org/10.1080/10937404.20 14.884956. Barr, D. B., R. Bravo, G. Weerasekera, L. M. Caltabiano, R. D. Whitehead, A. O. Olsson, S. P. Caudill, S. E. Schober, J. L. Pirkle, E. J. Sampson, R. J. Jackson, and L. L. Needham. 2004. Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population. Environmental Health Perspectives 112 (2):186–200. https://doi. org/10.1289/ehp.6503. Bartolomei, M. S. 2009. Genomic imprinting: Employing and avoiding epigenetic processes. Genes & Development 23(18):2124–2133. https://doi.org/10.1101/gad.1841409. Bellinger, D. C. 2012. A strategy for comparing the contributions of environmental chemicals and other risk factors to neurodevelopment of children. Environmental Health Perspec- tives 120(4):501–507. https://doi.org/10.1289/ehp.1104170. Bellinger, D. C. 2013. Prenatal exposures to environmental chemicals and children’s neuro- development: An update. Safety and Health at Work 4(1):1–11. https://doi.org/10.5491/ SHAW.2013.4.1.1. Ben-Shalom, R., C. M. Keeshen, K. N. Berrios, J. Y. An, S. J. Sanders, and K. J. Bender. 2017. Opposing effects on NaV1.2 function underlie differences between SCN2A variants observed in individuals with autism spectrum disorder or infantile seizures. Biological Psychiatry 82(3):224–232. https://doi.org/10.1016/j.biopsych.2017.01.009. 57 PREPUBLICATION COPY—Uncorrected Proofs

58 ENVIRONMENTAL NEUROSCIENCE Berkowitz, A. 2020. Playing the genome card. Journal of Neurogenetics 34(1):189–197. https://doi.org/10.1080/01677063.2019.1706093. Bernier, R., C. Golzio, B. Xiong, H. A. Stessman, B. P. Coe, O. Penn, K. Witherspoon, J. Gerdts, C. Baker, A. T. Vulto-van Silfhout, J. H. Schuurs-Hoeijmakers, M. Fichera, P. Bosco, S. Buono, A. Alberti, P. Failla, H. Peeters, J. Steyaert, L. E. L. M. Vissers, L. Francescatto, H. C. Mefford, J. A. Rosenfeld, T. Bakken, B. J. O’Roak, M. Pawlus, R. Moon, J. Shendure, D. Amaral, E. Lein, J. Rankin, C. Romano, B. B. A. de Vries, N. Katsanis, and E. Eichler. 2014. Disruptive CHD8 mutations define a subtype of autism early in development. Cell 158(2):263–276. https://doi.org/10.1016/j.cell.2014.06.017. Betarbet, R., T. B. Sherer, G. MacKenzie, M. Garcia-Osuna, A. V. Panov, and J. T. Greenamyre. 2000. Chronic systemic pesticide exposure reproduces features of Parkinson’s disease. Nature Neuroscience 3(12):1301–1306. https://doi.org/10.1038/81834. Boutwell, B. B., E. J. Nelson, Z. Qian, M. G. Vaughn, J. P. Wright, K. M. Beaver, J. C. Barnes, M. Petkovsek, R. Lewis, M. Schootman, and R. Rosenfeld. 2017. Aggregate-level lead exposure, gun violence, homicide, and rape. PloS One 12(11):e0187953. https://doi. org/10.1371/journal.pone.0187953. Braun, J. M., R. S. Kahn, T. Froehlich, P. Auinger, and B. P. Lanphear. 2006. Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children. En- vironmental Health Perspectives 114(12):1904–1909. https://doi.org/10.1289/ehp.9478. Brown, E. S. 2012. Measuring individual exposomes. Emerging Science for Environmental Heatlh Decisions, November 2012. http://nas-sites.org/emergingscience (accessed August 12, 2020). Cacciottolo, M., T. E. Morgan, A. A. Saffari, F. Shirmohammadi, H. J. Forman, C. Sioutas, and C. E. Finch. 2020. Traffic-related air pollutants (TRAP-PM) promote neuronal amy- loidogenesis through oxidative damage to lipid rafts. Free Radical Biology & Medicine 147:242–251. https://doi.org/10.1016/j.freeradbiomed.2019.12.023. Calafat, A. M., Z. Kuklenyik, J. A. Reidy, S. P. Caudill, J. Ekong, and L. L. Needham. 2005. Urinary concentrations of bisphenol A and 4-Nonylphenol in a human reference population. Environmental Health Perspectives 113(4):391–395. https://doi.org/10.1289/ ehp.7534. California Department of Pesticide Regulation. 2020. Pesticide use reporting. https://www. cdpr.ca.gov/docs/pur/purmain.htm (accessed September 10, 2020). Cannon, J. R., and J. Timothy Greenamyre. 2011. The role of environmental exposures in neu- rodegeneration and neurodegenerative diseases. Toxicological Sciences 124(2):225–250. https://doi.org/10.1093/toxsci/kfr239. Casanova, R., X. Wang, J. Reyes, Y. Akita, M. L. Serre, W. Vizuete, H. C. Chui, I. Driscoll, S. M. Resnick, M. A. Espeland, J.-C. Chen, and WHIMS-MRI Study Group. 2016. A voxel-based morphometry study reveals local brain structural alterations associated with ambient fine particles in older women. Frontiers in Human Neuroscience 10:495. https:// doi.org/10.3389/fnhum.2016.00495. Casanova, R., R. T. Barnard, S. A. Gaussoin, S. Saldana, K. M. Hayden, J. E. Manson, R. B. Wallace, S. R. Rapp, S. M. Resnick, M. A. Espeland, J.-C. Chen, and WHIMS- MRI Study Group and the Alzheimer’s Disease Neuroimaging Initiative. 2018. Using high-dimensional machine learning methods to estimate an anatomical risk factor for Alzheimer’s disease across imaging databases. NeuroImage 183:401–411. https://doi. org/10.1016/j.neuroimage.2018.08.040. Cattani, D., P. Acordi Cesconetto, M. Kruger Tavares, E. Benedetti Parisotto, P. A. De Oliveira, C. E. Heinz Rieg, M. Concli Leite, R. D. Schröder Prediger, N. Cubas Wendt, G. Razzera, D. Wilhelm Filho, and A. Zamoner. 2017. Developmental exposure to glyphosate-based herbicide and depressive-like behavior in adult offspring: Implication of glutamate ex- citotoxicity and oxidative stress. Toxicology 387(July):67–80. https://doi.org/10.1016/j. tox.2017.06.001. PREPUBLICATION COPY—Uncorrected Proofs

APPENDIX A 59 Chen, H., H. Seifikar, N. Larocque, Y. Kim, I. Khatib, C. J. Fernandez, N. Abello, and J. F. Robinson. 2019. Using a multi-stage HESC model to characterize BDE-47 toxicity during neurogenesis. Toxicological Sciences 171(1):221–234. https://doi.org/10.1093/ toxsci/kfz136. Christensen, J., T. Koops Grønborg, M. Juul Sørensen, D. Schendel, E. Thorlund Parner, L. Henning Pedersen, and M. Vestergaard. 2013. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA 309(16):1696–1703. https://doi. org/10.1001/jama.2013.2270. Cory-Slechta, D. A., M. B. Virgolini, S. Liu, and D. Weston. 2012. Enhanced stimulus sequence-dependent repeated learning in male offspring after prenatal stress alone or in conjunction with lead exposure. Neurotoxicology 33(5):1188–1202. https://doi. org/10.1016/j.neuro.2012.06.013. Costello, S., M. Cockburn, J. Bronstein, X. Zhang, and B. Ritz. 2009. Parkinson’s disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California. American Journal of Epidemiology 169(8):919–926. https:// doi.org/10.1093/aje/kwp006. Coulton, C., F. García-Cobian Richter, Y. Cho, J. Park, and R. Fischer. 2020. Downstream consequences of childhood lead poisoning. Center on Urban Poverty and Community Development, Case Western Reserve University. https://case.edu/socialwork/povertycen- ter/sites/case.edu.povertycenter/files/2020-07/Downstream_06182020_rev07082020.pdf (accessed August 12, 2020). Curtin, P., C. Austin, A. Curtin, C. Gennings, C. Figueroa-Romero, K. A. Mikhail, T. M. Botero, S. A. Goutman, E. L. Feldman, and M. Arora. 2020. Dysregulated biodynam- ics in metabolic attractor systems precede the emergence of amyotrophic lateral scle- rosis. PLoS Computational Biology 16(4):e1007773. https://doi.org/10.1371/journal. pcbi.1007773. Cushing, L., J. Faust, L. Meehan August, R. Cendak, W. Wieland, and G. Alexeeff. 2015. Racial/ethnic disparities in cumulative environmental health impacts in California: Evi- dence from a statewide environmental justice screening tool (CalEnviroScreen 1.1). American Journal of Public Health 105(11):2341–2348. https://doi.org/10.2105/ AJPH.2015.302643. De Rubeis, S., X. He, A. P. Goldberg, C. S. Poultney, K. Samocha, A. Erucment Cicek, Y. Kou, L. Liu, M. Fromer, S. Walker, T. Singh, L. Klei, J. Kosmicki, S.-C. Fu, B. Aleksic, M. Biscaldi, P. F. Bolton, J. M. Brownfeld, J. Cai, N. G. Campbell, A. Carracedo, M. H. Chahrour, A. G. Chiocchetti, H. Coon, E. L. Crawford, L. Crooks, S. R. Curran, G. Dawson, E. Duketis, B. A. Fernandez, L. Gallagher, E. Geller, S. J. Guter, R. S. Hill, I. Ionita-Laza, P. Jimenez Gonzalez, H. Kilpinen, S. M. Klauck, A. Kolevzon, I. Lee, J. Lei, T. Lehtimäki. C.-F. Lin, A. Ma’ayan, C. R. Marshall, A. L. McInnes, B. Neale, M. J. Owen, N. Ozaki, M. Parellada, J. R. Parr, S. Purcell, K. Puura, D. Rajagopalan, K. Rehnström, A. Reichenberg, A. Sabo, M. Sachse, S. J. Sanders, C. Schafer, M. Schulte- Rüther, D. Skuse, C. Stevens, P. Szatmari, K. Tammimies, O. Valladares, A. Voren, L.-S. Wang, L. A. Weiss, J. Willsey, T. W. Yu, R. K. C. Yuen, The DDD Study, Homozygos- ity Mapping Collaborative for Autism, UK10K Consortium, The Autism Sequencing Consortium, E. H. Cook, C. M. Freitag, M. Gill, C. M. Hultman, T. Lehner, A. Palotie, G. D. Schellenberg, P. Sklar, M. W. State, J. S. Sutcliffe, C. A. Walsh, S. W. Scherer, M. E. Zwick, J. C. Barrett, D. J. Cutler, K. Roeder, B. Devlin, M. J. Daly, and J. D. Bux- buam. 2014. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature 515(7526):209–215. https://doi.org/10.1038/nature13772. De Miranda, B. and J. Greenamyre. 2020. Trichloroethylene, a ubiquitous environmental contaminant in the risk for Parkinson’s disease. Environmental Science: Processes and Impacts 22(3):543–554. https://doi.org/10.1039/C9EM00578A. PREPUBLICATION COPY—Uncorrected Proofs

60 ENVIRONMENTAL NEUROSCIENCE Di Maio, R., E. K. Hoffman, E. M. Rocha, M. T. Keeney, L. H. Sanders, B. R. De Miranda, A. Zharikov, A. Van Laar, A. F. Stepan, T. A. Lanz, J. K. Kofler, E. A. Burton, D. R. Alessi, T. G. Hastings, and J. T. Greenamyre. 2018. LRRK2 activation in idiopathic Parkinson’s disease. Science Translational Medicine 10(451):eaar5429. https://doi.org/10.1126/ scitranslmed.aar5429. Dolinoy, D. C., D. Huang, and R. L. Jirtle. 2007. Maternal nutrient supplementation coun- teracts bisphenol A-induced DNA hypomethylation in early development. Proceedings of the National Academy of Sciences of the United States of America 104(32):13056– 13061. https://doi.org/10.1073/pnas.0703739104. EC (European Commission). 2003. Technical guidance document on risk assessment. https:// echa.europa.eu/documents/10162/16960216/tgdpart1_2ed_en.pdf (accessed September 10, 2020). Ellis, B. J., W. T. Boyce, J. Belsky, M. J. Bakermans-Kranenburg, and M. H. Van IJzendoorn. 2011. Differential susceptibility to the environment: An evolutionary–neurodevelopmental theory. Development and Psychopathology 23(1):7–28 Emer, L. R., A. E. Kalkbrenner, M. O’Brien, A. Yan, R. A. Cisler, and L. Weinhardt. 2020. Association of childhood blood lead levels with firearm violence perpetration and victim- ization in Milwaukee. Environmental Research 180:108822. https://doi.org/10.1016/j. envres.2019.108822. EPA (Environmental Protection Agency). 2020. Conducting a Human Health Risk Assessment: The 4 Step Risk Assessment Process. https://www.epa.gov/risk/conducting-human-health- risk-assessment (accessed September 9, 2020). Faraone, S. V., and H. Larsson. 2019. Genetics of attention deficit hyperactivity disorder. Molecular Psychiatry 24(4):562–575. https://doi.org/10.1038/s41380-018-0070-0. Figueroa-Romero, C., K. A. Mikhail, C. Gennings, P. Curtin, G. A. Bello, T. M. Botero, S. A. Goutman, E. L. Feldman, M. Arora, and C. Austin. 2020. Early life metal dysregula- tion in amyotrophic lateral sclerosis. Annals of Clinical and Translational Neurology 7(6):872–882. https://doi.org/10.1002/acn3.51006. Finch, C. E., and A. M. Kulminski. 2019. The Alzheimer’s disease exposome. Alzheimer’s & Dementia 15(9):1123–1132. https://doi.org/10.1016/j.jalz.2019.06.3914. Finch, C. E., and A. M. Kulminski. 2020. The ApoE locus and COVID-19: Are we go- ing where we have been?. The Journals of Gerontology: Series A glaa200. https://doi. org/10.1093/gerona/glaa200. Finch, C. E., and T. E. Morgan. 2020. Developmental consequences of exposure to air pollu- tion for adult aging. Annual Review of Developmental Psychology. Forman, H. J., and C. E. Finch. 2018. A critical review of assays for hazardous components of air pollution. Free Radical Biology & Medicine 117:202–217. https://doi.org/10.1016/j. freeradbiomed.2018.01.030. Furlong, M. A., D. Boyd Barr, M. S. Wolff, and S. M. Engel. 2017. Prenatal exposure to py- rethroid pesticides and childhood behavior and executive functioning. Neurotoxicology 62(September):231–238. https://doi.org/10.1016/j.neuro.2017.08.005. Gatz, M., C. A. Reynolds, L. Fratiglioni, B. Johansson, J. A. Mortimer, S. Berg, A. Fiske, and N. L. Pedersen. 2006. Role of genes and environments for explaining Alzheimer disease. Ar- chives of General Psychiatry 63(2):168–174. https://doi.org/10.1001/archpsyc.63.2.168. Goutman, S. A., J. Boss, A. Patterson, B. Mukherjee, S. Batterman, and E. L. Feldman. 2019. High plasma concentrations of organic pollutants negatively impact survival in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry 90(8):907–912. https://doi.org/10.1136/jnnp-2018-319785. Grande, G., P. L. S. Ljungman, K. Eneroth, T. Bellander, and D. Rizzuto. 2020. Asso- ciation between cardiovascular disease and long-term exposure to air pollution with the risk of dementia. JAMA Neurology 77(7):801–809. https://doi.org/10.1001/ jamaneurol.2019.4914. PREPUBLICATION COPY—Uncorrected Proofs

APPENDIX A 61 Haghani, A., M. Cacciottolo, K. R. Doty, C. D’Agostino, M. Thorwald, N. Safi, M. E. Levine, C. Sioutas, T. C. Town, H. J. Forman, H. Zhang, T. E. Morgan, and C. E. Finch. 2020. Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions. ELife 9. https://doi.org/10.7554/eLife.54822. Hamblin, J. 2014. The toxins that threaten our brains. The Atlantic. March 18. https://www. theatlantic.com/health/archive/2014/03/the-toxins-that-threaten-our-brains/284466 (ac- cessed September 8, 2020). HHS (Department of Health and Human Services). 2016. National Toxicology Program—14th Report on Carcinogens. https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/roc/ index.html?utm_source=direct&utm_medium= prod&utm_campaign=ntpgolinks&utm_ term=roc14 (accessed September 9, 2020). Johnson, R., K. Ramsey-White, and C. H. Fuller. 2016. Socio-demographic differences in toxic release inventory siting and emissions in metro Atlanta. International Journal of Environ- mental Research and Public Health 13(8):747. https://doi.org/10.3390/ijerph13080747. Jones, D. P. 2016. Sequencing the exposome: A call to action. Toxicology Reports 3:29–45. https://doi.org/10.1016/j.toxrep.2015.11.009. Kagawa, N., and T. Nagao. 2018. Neurodevelopmental toxicity in the mouse neocortex fol- lowing prenatal exposure to acetamiprid. Journal of Applied Toxicology 38(12):1521– 1528. https://doi.org/10.1002/jat.3692. Kalish, J. M., C. Jiang, and M. S. Bartolomei. 2014. Epigenetics and imprinting in human disease. The International Journal of Developmental Biology 58(2–4):291–298. https:// doi.org/10.1387/ijdb.140077mb. Kelada, S. N. P., H. Checkoway, S. L. R. Kardia, C. S. Carlson, P. Costa-Mallen, D. L. Ea- ton, J. Firestone, K. M. Powers, P. D. Swanson, G. M. Franklin, W. T. Longstretch, Jr., T-S. Weller, Z. Afsharinejad, and L. G. Costa. 2006. 5’ and 3’ region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson’s disease risk: A hypothesis-generating study. Human Molecular Genetics 15(20):3055–3062. https:// doi.org/10.1093/hmg/ddl247. Kulick, E. R., M. S. V. Elkind, A. K. Boehme, N. R. Joyce, N. Schupf, J. D. Kaufman, R. May- eux, J. J. Manly, and G. A. Wellenius. 2020. Long-term exposure to ambient air pollution, APOE-Ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan. Environment International 136:105440. https://doi.org/10.1016/j.envint.2019.105440. Lam, J., B. P. Lanphear, D. Bellinger, D. A. Axelrad, J. McPartland, P. Sutton, L. Davidson, N. Daniels, S. Sen, and T. J. Woodruff. 2017. Developmental PBDE exposure and IQ/ADHD in childhood: A systematic review and meta-analysis. Environmental Health Perspectives 125(8):086001. https://doi.org/10.1289/EHP1632. Lanphear, B. P., R. Hornung, J. Khoury, K. Yolton, P. Baghurst, D. C. Bellinger, R. L. Canfield, K. N. Dietrich, R. Bornschein, T. Greene, S. J. Rothenberg, H. L. Needleman, L. Schnaas, G. Wasserman, J. Graziano, and R. Roberts. 2005. Low-level environmental lead expo- sure and children’s intellectual function: An international pooled analysis. Environmental Health Perspectives 113(7):894–899. https://doi.org/10.1289/ehp.7688. Lee, P.-C., S. L. Rhodes, J. S. Sinsheimer, J. Bronstein, and B. Ritz. 2013. Functional paraox- onase 1 variants modify the risk of Parkinson’s disease due to organophosphate exposure. Environment International 56:42–47. https://doi.org/10.1016/j.envint.2013.03.004. Lee, P.-C., O. Raaschou-Nielsen, C. M. Lill, L. Bertram, J. S. Sinsheimer, J. Hansen, and B. Ritz. 2016. Gene-environment interactions linking air pollution and inflammation in Parkinson’s disease. Environmental Research 151:713–720. https://doi.org/10.1016/j. envres.2016.09.006. Li, J.-Q., L. Tan, and J.-T. Yu. 2014. The role of the LRRK2 gene in Parkinsonism. Molecular Neurodegeneration 9:47. https://doi.org/10.1186/1750-1326-9-47. PREPUBLICATION COPY—Uncorrected Proofs

62 ENVIRONMENTAL NEUROSCIENCE Miller, G. W., and D. P. Jones. 2014. The nature of nurture: Refining the definition of the exposome. Toxicological Sciences 137(1):1–2. https://doi.org/10.1093/toxsci/kft251. Miranda, M. L., D. Kim, M. A. Overstreet Galeano, C. J. Paul, A. P. Hull, and S. P. Morgan. 2007. The relationship between early childhood blood lead levels and performance on end-of-grade tests. Environmental Health Perspectives 115(8):1242–1247. https://doi. org/10.1289/ehp.9994. Miranda, M. L., P. Maxson, and D. Kim. 2010. Early childhood lead exposure and excep- tionality designations for students. International Journal of Child Health and Human Development 3(1):77–84. Morello-Frosch, R., L. J. Cushing, B. M. Jesdale, J. M. Schwartz, W. Guo, T. Guo, M. Wang, S. Harwani, S. E. Petropoulou, W. Duong, J. S. Park, M. Petreas, R. Gajek, J. Alvaran, J. She, D. Dobraca, R. Das, and T. J. Woodruff. 2016. Environmental chemicals in an urban population of pregnant women and their newborns from San Francisco. Environmental Science & Technology 50(22):12464–12472. https://doi.org/10.1021/acs.est.6b03492. Mullen, C., S. Grineski, T. Collins, W. Xing, R. Whitaker, T. Sayahi, T. Becnel, P. Goffin, P.-E. Gaillardon, M. Meyer, and K. Kelly. 2020. Patterns of distributive environmental ineq- uity under different PM2.5 air pollution scenarios for Salt Lake County public schools. Environmental Research 186:109543. https://doi.org/10.1016/j.envres.2020.109543. Narayan, S., Z. Liew, K. Paul, P-C. Lee, J. S. Sinsheimer, J. M. Bronstein, and B. Ritz. 2013. Household organophosphorus pesticide use and Parkinson’s disease. International Jour- nal of Epidemiology 42(5):1476–1485. https://doi.org/10.1093/ije/dyt170. Neal, A. P., K. H. Stansfield, P. F. Worley, R. E. Thompson, and T. R. Guilarte. 2010. Lead exposure during synaptogenesis alters vesicular proteins and impairs vesicular release: Potential role of NMDA receptor–dependent BDNF signaling. Toxicological Sciences 116(1):249–263. https://doi.org/10.1093/toxsci/kfq111. Niedzwiecki, M. M., D. I. Walker, J. C. Howell, K. D. Watts, D. P. Jones, G. W. Miller, and W. T. Hu. 2020. High-resolution metabolomic profiling of Alzheimer’s disease in plasma. Annals of Clinical and Translational Neurology 7(1):36–45. https://doi.org/10.1002/ acn3.50956. Nihei, M. K., N. L. Desmond, J. L. McGlothan, A. C. Kuhlmann, and T. R. Guilarte. 2000. N-methyl-D-aspartate receptor subunit changes are associated with lead-induced deficits of long-term potentiation and spatial learning. Neuroscience 99(2):233–242. Nkomo, P., A. Mathee, N. Naicker, J. Galpin, L. M. Richter, and S. A. Norris. 2017. The as- sociation between elevated blood lead levels and violent behavior during late adolescence: The South African birth to twenty plus cohort. Environment International 109:136–145. https://doi.org/10.1016/j.envint.2017.09.004. NRC (National Research Council). 1983. Risk assessment in the federal government: Manag- ing the process. Washington, DC: National Academy Press. https://doi.org/10.17226/366. NRC. 1993. Pesticides in the diets of infants and children. Washington, DC: National Acad- emy Press. https://doi.org/10.17226/2126. NRC. 2008. Phthalates and cumulative risk assessment: The tasks ahead. Washington, DC: The National Academies Press. https://doi.org/10.17226/12528. O’Roak, B. J., H. A. Stessman, E. A. Boyle, K. T. Witherspoon, B. Martin, C. Lee, L. Vives, et al. 2014. Recurrent de novo mutations implicate novel genes underlying simplex autism risk. Nature Communications 5:5595. https://doi.org/10.1038/ncomms6595. Ospina, M., L-Y. Wong, S. E. Baker, A. Bishop Serafim, P. Morales-Agudelo, and A. M. Cala- fat. 2019. Exposure to neonicotinoid insecticides in the U.S. general population: Data from the 2015–2016 National Health and Nutrition Examination Survey. Environmental Research 176:108555. https://doi.org/10.1016/j.envres.2019.108555. Packer, A. 2018. Enrichment of factors regulating canonical Wnt signaling among autism risk genes. Molecular Psychiatry 23(3):492–493. https://doi.org/10.1038/mp.2016.228. PREPUBLICATION COPY—Uncorrected Proofs

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66 ENVIRONMENTAL NEUROSCIENCE Wild, C. P. 2005. Complementing the genome with an “exposome”: The outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol- ogy, Biomarkers & Prevention 14(8):1847–1850. https://doi.org/10.1158/1055-9965. EPI-05-0456. Woodruff, T. J., A. R. Zota, and J.M. Schwartz. 2011. Environmental chemicals in pregnant women in the United States: NHANES 2003–2004. Environmental Health Perspectives 119(6):878–885. https://doi.org/10.1289/ehp.1002727. Xin, F., E. Fischer, C. Krapp, E. N. Krizman, Y. Lan, C. Mesaros, N. W. Snyder, A. Bansal, M. B. Robinson, R. A. Simmons, and M. S. Bartolomei. 2018. Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunc- tion. Hormones and Behavior 102:93–104. https://doi.org/10.1016/j.yhbeh.2018.05.010. Younan, D., A. J. Petkus, K. F. Widaman, X. Wang, R. Casanova, M. A. Espeland, M. Gatz, V. W. Henderson, J. E. Manson, S. R. Rapp, B. C. Sachs, M. L. Serre, S. A. Gaussoin, R. Barnard, S. Saldana, W. Vizuete, D. P. Beavers, J. A. Salinas, H. C.. Chui, S. M. Resnick, S. A. Shumaker, and J.-C. Chen. 2020. Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer’s disease. Brain 143(1):289– 302. https://doi.org/10.1093/brain/awz348. Zhang, X.-L., J. L. McGlothan, O. Miry, K. H. Stansfield, M. K. Loth, P. K. Stanton, and T. R. Guilarte. 2018. From the cover: 7,8-dihydroxyflavone rescues lead-induced impairment of vesicular release: A novel therapeutic approach for lead intoxicated children. Toxico- logical Sciences 161(1):186–195. https://doi.org/10.1093/toxsci/kfx210. Zota, A. R., J.-S. Park, Y. Wang, M. Petreas, R. T. Zoeller, and T. J. Woodruff. 2011. Poly- brominated diphenyl ethers, hydroxylated polybrominated diphenyl ethers, and measures of thyroid function in second trimester pregnant women in California. Environmental Science & Technology 45(18):7896–7905. https://doi.org/10.1021/es200422b. Zota, A. R., L. Linderholm, J.-S. Park, M. Petreas, T. Guo, M. L. Privalsky, R. T. Zoeller, and T. J. Woodruff. 2013. Temporal Comparison of PBDEs, OH-PBDEs, PCBs, and OH-PCBs in the Serum of Second Trimester Pregnant Women Recruited from San Francisco General Hospital, California. Environmental Science & Technology 47(20):11776–11784. https:// doi.org/10.1021/es402204y. PREPUBLICATION COPY—Uncorrected Proofs

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Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop Get This Book
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Humans are potentially exposed to more than 80,000 toxic chemicals in the environment, yet their impacts on brain health and disease are not well understood. The sheer number of these chemicals has overwhelmed the ability to determine their individual toxicity, much less potential interactive effects. Early life exposures to chemicals can have permanent consequences for neurodevelopment and for neurodegeneration in later life. Toxic effects resulting from chemical exposure can interact with other risk factors such as prenatal stress, and persistence of some chemicals in the brain over time may result in cumulative toxicity. Because neurodevelopmental and neurodegenerative disorders - such as attention-deficit hyperactivity disorder and Parkinson's disease - cannot be fully explained by genetic risk factors alone, understanding the role of individual environmental chemical exposures is critical.

On June 25, 2020, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders hosted a workshop to lay the foundation for future advances in environmental neuroscience. The workshop was designed to explore new opportunities to bridge the gap between what is known about the genetic contribution to brain disorders and what is known, and not known, about the contribution of environmental influences, as well as to discuss what is known about how genetic and environmental factors interact. This publication summarizes the presentation and discussion of the workshop.

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