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The Use of Systematic Review in EPA's Toxic Substances Control Act Risk Evaluations (2021)

Chapter: Appendix C: Documents Reviewed by the Committee

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Suggested Citation:"Appendix C: Documents Reviewed by the Committee." National Academies of Sciences, Engineering, and Medicine. 2021. The Use of Systematic Review in EPA's Toxic Substances Control Act Risk Evaluations. Washington, DC: The National Academies Press. doi: 10.17226/25952.
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Page 69

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Appendix C Documents Reviewed by the Committee In order to complete its review, the committee reviewed several documents that are listed below. Many are available through the provided links and others are available through the National Academies’ Public Access File (as are all presentations made to the committee; see the agendas for the public meetings in Appendix B). In order to review these documents, please email paro@nas.edu for more information. 1. EPA (U.S. Environmental Protection Agency). 2018. Application of Systematic Review in TSCA Risk Evaluations. Office of Chemical Safety and Pollution Prevention (OCSPP), Washington, DC. https://www.epa.gov/sites/product Office of Chemical Safety and Pollution Prevention (OCSPP) ion/files/2018-06/documents/final_application_of_sr_in_tsca_05-31- 18.pdf (last viewed November 5, 2020). 2. EPA. 2020. Draft Risk Evaluation for Trichloroethylene. Office of Chemical Safety and Pollution Prevention (OCSPP), Washington, DC. https://www.epa.gov/sites/production/files/2020-02/documents/1_draft_risk_evaluation_for_ trichloroethylene_tce_public.pdf (last viewed November 5, 2020). a. Draft evaluation main page: https://www.epa.gov/assessing-and-managing- chemicals-under-tsca/draft-risk-evaluation-trichloroethylene b. Docket entry: https://beta.regulations.gov/document/EPA-HQ-OPPT-2019-0500-0001 c. Scope, Literature Search Strategy, and Bibliography Documents: https://www.epa.gov/assessing-and-managing-chemicals-under- tsca/trichloroethylene-tce-scope-document-and-supplemental d. Problem Formulation Document: https://www.epa.gov/assessing-and-managing- chemicals-under-tsca/trichloroethylene-tce-problem-formulation 3. EPA. 2020. Risk Evaluation for 1-Bromopropane (n-Propyl Bromide). Office of Chemical Safety and Pollution Prevention (OCSPP), Washington, DC. https://www.epa.gov/sites/production/files/2020-08/documents/risk_evaluation_for_1- bromopropane_n-propyl_bromide.pdf (last viewed November 5, 2020). a. Evaluation main page: https://www.epa.gov/assessing-and-managing-chemicals- under-tsca/final-risk-evaluation-1-bromopropane b. Docket entry: https://beta.regulations.gov/document/EPA-HQ-OPPT-2019-0235-0001 c. Scope, Literature Search Strategy, and Bibliography Documents: https://www.epa.gov/assessing-and-managing-chemicals-under-tsca/1- bromopropane-1-bp-scope-document-and-supplemental d. Problem Formulation Document: https://www.epa.gov/assessing-and-managing- chemicals-under-tsca/1-bromopropane-1-bp-problem-formulation 4. Seema Schappelle, PhD, Office of Chemical Safety and Pollution Prevention, U.S. EPA. Text document with answer to committee questions sent on June 10, 2020. Available at paro@nas.edu. Prepublication Copy 69

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Systematic review - a scientific investigation that focuses on a specific question and uses explicit, prespecified scientific methods to identify, select, assess, and summarize the findings of similar but separate studies - has become the foundation for assessing evidence to be used for decision making in a variety of health contexts, including health care and public health.

At the request of the Environmental Protection Agency (EPA), this publication reviews EPA's 2018 guidance document Application of Systematic Review in TSCA (Toxic Substances and Control Act) Risk Evaluations and associated materials to determine whether the process is comprehensive, workable, objective, and transparent.

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