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Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25998.
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Appendix A

References

Abbasi, J. 2019. Older patients (still) left out of cancer clinical trials. JAMA 322(18):1751–1753.

Akpan, A., C. Roberts, K. Bandeen-Roche, B. Batty, C. Bausewein, D. Bell, D. Bramley, J. Bynum, I. D. Cameron, L. K. Chen, A. Ekdahl, A. Fertig, T. Gentry, M. Harkes, D. Haslehurst, J. Hope, D. R. Hurtado, H. Lyndon, J. Lynn, M. Martin, R. Isden, F. M. Raso, S. Shaibu, J. Shand, C. Sherrington, S. Sinha, G. Turner, N. De Vries, G. J. Yi, J. Young, and J. Banerjee. 2018. Standard set of health outcome measures for older persons. BMC Geriatrics 18(1):36.

Alvis, B. D., and C. G. Hughes. 2015. Physiology considerations in the geriatric patient. Anesthesiology Clinics 33(3):447–456.

Anderson, M. 2019. Mobile technology and home broadband 2019. Pew Research Center. https://www.pewresearch.org/internet/2019/06/13/mobile-technology-and-home-broadband-2019 (accessed November 12, 2020).

Anderson, M., and A. Perrin. 2017. Tech adoption climbs among older adults. Pew Research Center. https://www.pewresearch.org/internet/2017/05/17/tech-adoption-climbs-among-older-adults (accessed November 12, 2020).

Anderson, A., D. Borfitz, and K. Getz. 2018. Global public attitudes about clinical research and patient experiences with clinical trials. JAMA Network Open 1(6):e182969.

Angus, D. C. 2015. Fusing randomized trials with big data: The key to self-learning health care systems? JAMA 314(8):767–768.

Angus, D. C., B. M. Alexander, S. Berry, M. Buxton, R. Lewis, M. Paoloni, S. A. R. Webb, S. Arnold, A. Barker, D. A. Berry, M. J. M. Bonten, M. Brophy, C. Butler, T. F. Cloughesy, L. P. G. Derde, L. J. Esserman, R. Ferguson, L. Fiore, S. C. Gaffey, J. M. Gaziano, K. Giusti, H. Goossens, S. Heritier, B. Hyman, M. Krams, K. Larholt, L. M. LaVange, P. Lavori, A. W. Lo, A. J. London, V. Manax, C. McArthur, G. O’Neill, G. Parmigiani, J. Perlmutter, E. A. Petzold, C. Ritchie, K. M. Rowan, C. W. Seymour, N. I. Shapiro, D. M. Simeone, B. Smith, B. Spellberg, A. D. Stern, L. Trippa, M. Trusheim, K. Viele, P. Y. Wen, and J. Woodcock. 2019. Adaptive platform trials: Definition, design, conduct and reporting considerations. Nature Reviews Drug Discovery 18:797–807.

Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25998.
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Bai, J. P. F., G. J. Burckart, and A. E. Mulberg. 2016. Literature review of gastrointestinal physiology in the elderly, in pediatric patients, and in patients with gastrointestinal diseases. Journal of Pharmaceutical Sciences 105(2):476–483.

Balls-Berry, J., L. C. Dacy, and J. Balls. 2015. “Heard it through the grapevine”: The Black barbershop as a source of health information. Hektoen International 7(3).

Beck, C. A., D. B. Beran, K. M. Biglan, C. M. Boyd, E. R. Dorsey, P. N. Schmidt, R. Simone, A. W. Willis, N. B. Galifianakis, M. Katz, C. M. Tanner, K. Dodenhoff, J. Aldred, J. Carter, A. Fraser, J. Jimenez-Shahed, C. Hunter, M. Spindler, S. Reichwein, Z. Mari, B. Dunlop, J. C. Morgan, D. McLane, P. Hickey, L. Gauger, I. H. Richard, N. I. Mejia, G. Bwala, M. Nance, L. C. Shih, C. Singer, S. Vargas-Parra, C. Zadikoff, N. Okon, A. Feigin, J. Ayan, C. Vaughan, R. Pahwa, R. Dhall, A. Hassan, S. DeMello, S. S. Riggare, P. Wicks, M. A. Achey, M. J. Elson, S. Goldenthal, H. T. Keenan, R. Korn, H. Schwarz, S. Sharma, E. A. Stevenson, and W. Zhu. 2017. National randomized controlled trial of virtual house calls for Parkinson disease. Neurology 89(11):1152–1161.

Benjamin, E. J., M. J. Blaha, S. E. Chiuve, M. Cushman, S. R. Das, R. Deo, S. D. de Ferranti, J. Floyd, M. Fornage, C. Gillespie, C. R. Isasi, M. C. Jiménez, L. Chaffin Jordan, S. E. Judd, D. Lackland, J. H. Lichtman, L. Lisabeth, S. Liu, C. T. Longenecker, R. H. Mackey, K. Matsushita, D. Mozaffarian, M. E. Mussolino, K. Nasir, R. W. Neumar, L. Palaniappan, D. K. Pandey, R. R. Thiagarajan, M. J. Reeves, M. Ritchey, C. J. Rodriguez, G. A. Roth, W. D. Rosamond, C. Sasson, A. Towfighi, C. W. Tsao, M. B. Turner, S. S. Virani, J. H. Voeks, J. Z. Willey, J. T. Wilkins, J. H. Wu, H. M. Alger, S. S. Wong, and P. Muntner. 2017. Heart disease and stroke statistics—2017 update: A report from the American Heart Association. Circulation 135:e146–e603.

Berenbrok, L. A., N. Gabriel, K. C. Coley, and I. Hernandez. 2020. Evaluation of frequency of encounters with primary care physicians vs. visits to community pharmacies among Medicare beneficiaries. JAMA Network Open 3(7):e209132.

Bernard, M. A., J. A. Clayton, and M. S. Lauer. 2018. Inclusion across the lifespan: NIH policy for clinical research. JAMA 320(15):1535–1536.

Bloch, F., and N. Charasz. 2014. Attitudes of older adults to their participation in clinical trials: A pilot study. Drugs Aging 31:373–377.

Bourgeois, F. T., L. Orenstein, S. Ballakur, K. D. Mandl, and J. P. A. Ioannidis. 2017. Exclusion of elderly people from randomized clinical trials of drugs for ischemic heart disease. Journal of the American Geriatrics Society 65(11):2354–2361.

Brandt, H. M., V. M. Young, D. A. Campbell, S. K. Choi, J. S. Seel, and D. B. Friedman. 2015. Federally qualified health centers’ capacity and readiness for research collaborations: Implications for clinical–academic–community partnerships. Clinical and Translational Science 8(4):391–393.

BrintzenhofeSzoc, K., J. I. Krok-Schoen, J. L. Pisegna, A. R. MacKenzie, B. Canin, E. Plotkin, L. M. Boehmer, and A. Shahrokni. 2021. Survey of cancer care providers’ attitude toward care of older adults with cancer during the COVID-19 pandemic. Journal of Geriatric Oncology 12(2):196–205.

Bushardt, R. L., E. B. Massey, T. W. Simpson, J. C. Ariail, and K. N. Simpson. 2008. Polypharmacy: Misleading, but manageable. Clinical Interventions in Aging 3(2):383–389.

Challa, H. J., M. A. Ameer, and K. R. Uppaluri. 2020. DASH diet to stop hypertension. Treasure Island, FL: StatPearls Publishing.

Chapman, J. E., D. A. Cadilhac, B. Gardner, J. Ponsford, R. Bhalla, and R. J. Stolwyk. 2021. Comparing face-to-face and videoconference completion of the Montreal Cognitive Assessment (MoCA) in community-based survivors of stroke. Journal of Telemedicine and Telecare 27(8):484–492. doi: 10.1177/1357633X19890788.

Comis, R. L., J. D. Miller, D. D. Colaizzi, and L. G. Kimmel. 2009. Physician-related factors involved in patient decisions to enroll onto cancer clinical trials. Journal of Oncology Practice 5(2):50–56.

Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25998.
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Curran, G. M., M. Bauer, B. Mittman, J. M. Pyne, and C. Stetler. 2012. Effectiveness-implementation hybrid designs: Combining elements of clinical effectiveness and implementation research to enhance public health impact. Medical Care 50(3):217–226.

Dellson, P., K. Nilsson, H. Jernström, and C. Carlsson. 2018. Patients’ reasoning regarding the decision to participate in clinical cancer trials: An interview study. Trials 19:528.

DeYoung, N., and B. V. Shenal. 2019. The reliability of the Montreal Cognitive Assessment using telehealth in a rural setting with veterans. Journal of Telemedicine and Telecare 25(4):197–203.

Dhruva, S. S., and R. F. Redberg. 2008. Variations between clinical trial participants and Medicare beneficiaries in evidence used for Medicare national coverage decisions. Archives of Internal Medicine 168(2):136–140.

Dresser, R. 1992. Wanted. Single, white male for medical research. Hastings Center Report 22(1):24–29.

Elkin-Frankston, S. 2017. Cognitive Assessment and Monitoring Platform for Integrative Research (CAMPFIRE).https://www.cra.com/publications/2017elkinfrankston2 (accessed November 12, 2020).

Ernst, F. R., and A. J. Grizzle. 2001. Drug-related morbidity and mortality: Updating the cost-of-illness model. Journal of the American Pharmaceutical Association 41(2):192–199.

FDA(U.S. Food and Drug Administration). 2020. Newdrugtherapyapprovals2019. https://www.fda.gov/drugs/new-drugs-fda-cders-new-molecular-entities-and-new-therapeutic-biological-products/novel-drug-approvals-2019 (accessed November 12, 2020).

Fialová, D., I. Kummer, M. Držai , and M. Leppee. 2018. Ageism in medication use in older patients. In Contemporary perspectives on ageism, edited by L. Ayalon and C. Tesch-Römer. International Perspectives on Aging, vol. 19. Cham, Switzerland: Springer.

Fiscella, K., G. Ogedegbe, H. He, J. Carroll, A. Cassells, M. Sanders, C. Khalida, B. D’Orazio, and J. N. Tobin. 2015. Blood pressure visit intensification study in treatment: Trial design. American Heart Journal 170(6):1202–1210.

Fiscella, K., M. Sanders, T. Holder, J. K. Carroll, A. Luque, A. Cassells, B. A. Johnson, S. K. Williams, and J. N. Tobin. 2020. The role of data and safety monitoring boards in implementation trials: When are they justified? Journal of Clinical and Translational Science 4(3):229–232.

Fulmer, T., K. S. Mate, and A. Berman. 2018. The age-friendly health system imperative. Journal of the American Geriatrics Society 66(1):22–24.

Gore, L., S. P. Ivy, F. M. Balis, E. Rubin, K. Thornton, M. Donoghue, S. Roberts, S. Bruinooge, J. Ersek, N. Goodman, C. Schenkel, and G. Reaman. 2017. Modernizing clinical trial eligibility: Recommendations of the American Society of Clinical Oncology–Friends of Cancer Research Minimum Age Working Group. Journal of Clinical Oncology 35(33):3781–3787.

Grandison, M. K., and F. D. Boudinot. 2000. Age-related changes in protein binding of drugs: Implications for therapy. Clinical Pharmacokinetics 38(3):271–279.

Gurwitz, J. 2014. The exclusion of older people from participation in cardiovascular trials. Virtual Mentor 16(5):365–368.

Heitkemper, E. M., L. Mamykina, J. N. Tobin, A. Cassells, and A. Smaldone. 2017. Baseline characteristics and technology training of underserved adults with type 2 diabetes in the Mobile Diabetes Detective (MoDD) randomized controlled trial. Diabetes Educator 43(6):576–588.

Helfand, B. K., M. Webb, S. L. Gartaganis, L. Fuller, C. Kwon, and S. K. Inouye. 2020. The exclusion of older persons from vaccine and treatment trials for coronavirus disease 2019—missing the target. JAMA Internal Medicine 180(11):1546–1549.

Herrera, A. P., S. A. Snipes, D. W. King, I. Torres-Vigil, D. S. Goldberg, and A. D. Weinberg. 2010. Disparate inclusion of older adults in clinical trials: Priorities and opportunities for policy and practice change. American Journal of Public Health 100(S1):S105–S112.

Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25998.
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Hilmer, S. N., H. Wu, and M. Zhang. 2019. Biology of frailty: Implications for clinical pharmacology and drug therapy in frail older people. Mechanisms of Ageing and Development 181:22–28.

IOM (Institute of Medicine). 1997. Pharmacokinetics and drug interactions in the elderly and special issues in elderly African-American populations: Workshop summary. Washington, DC: National Academy Press.

Jacobs, P., D. Anello, and S. Elkin-Frankston. 2019. Using design to connect patients, providers, and researchers: A Cognitive Assessment and Monitoring Platform for Integrative Research (CAMPFIRE). In Advances in human factors and ergonomics in healthcare and medical devices, edited by N. Lightner. AHFE 2018. Advances in Intelligent Systems and Computing, vol. 779. Cham, Switzerland: Springer.

Joinson, A. 2001. Self-disclosure in computer-mediated communication: The role of self-awareness and visual anonymity. European Journal of Social Psychology 31:177–192.

Karlawish, J., M. S. Cary, J. Rubright, and T. Tenhave. 2008. How redesigning AD clinical trials might increase study partners’ willingness to participate. Neurology 71(23):1883–1888.

Kluger, B. M., J. Miyasaki, M. Katz, N. Galifianakis, K. Hall, S. Pantilat, R. Khan, C. Friedman, W. Cernik, Y. Goto, J. Long, D. Fairclough, S. Sillau, and J. S. Kutner. 2020. Comparison of integrated outpatient palliative care with standard care in patients with Parkinson disease and related disorders: A randomized clinical trial. JAMA Neurology 77(5):551–560.

Kuehn, B. M. 2006. Industry, FDA warm to “adaptive” trials. JAMA 296(16):1955–1957.

Lam, J. R., J. L. Schneider, W. Zhao, and D. A. Corley. 2013. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. JAMA 310(22):2435–2442.

Lam, K., A. D. Lu, Y. Shi, and K. E. Covinsky. 2020. Assessing telemedicine unreadiness among older adults in the United States during the COVID-19 pandemic. JAMA Internal Medicine 180(10):1389–1391.

Levit, L. A., H. Singh, H. D. Klepin, and A. Hurria. 2018. Expanding the evidence base in geriatric oncology: Action items from an FDA–ASCO workshop. Journal of the National Cancer Institute 110(11):1163–1170.

Lichtman, S. M., R. D. Harvey, M. A. Damiette Smit, A. Rahman, M. A. Thompson, N. Roach, C. Schenkel, S. S. Bruinooge, P. Cortazar, D. Walker, and L. Fehrenbacher. 2017. Modernizing clinical trial eligibility criteria: Recommendations of the American Society of Clinical Oncology–Friends of Cancer Research Organ Dysfunction, Prior or Concurrent Malignancy, and Comorbidities Working Group. Journal of Clinical Oncology 35(33):3753–3759.

Lin, N. U., T. Prowell, A. R. Tan, M. Kozak, O. Rosen, L. Amiri-Kordestani, J. White, J. Sul, L. Perkins, K. Beal, R. Gaynor, and E. S. Kim. 2017. Modernizing clinical trial eligibility criteria: Recommendations of the American Society of Clinical Oncology–Friends of Cancer Research Brain Metastases Working Group. Journal of Clinical Oncology 35(33):3760–3773.

Lindeman, R. D., J. Tobin, and N. W. Shock. 1985. Longitudinal studies on the rate of decline in renal function with age. Journal of the American Geriatrics Society 33(4):278–285.

Locock, L., and L. Smith. 2010. Personal benefit, or benefiting others? Deciding whether to take part in clinical trials. Clinical Trials 8(1):85–93.

Mamykina, L., E. M. Heitkemper, A. M. Smaldone, R. Kukafka, H. J. Cole-Lewis, P. G. Davidson, E. D. Mynatt, A. Cassells, J. N. Tobin, and G. Hripcsak. 2017. Personal discovery in diabetes self-management: Discovering cause and effect using self-monitoring data. Journal of Biomedical Informatics 76:1–8.

Mangoni, A. A., and S. H. D. Jackson. 2004. Age-related changes in pharmacokinetics and pharmacodynamics: Basic principles and practical applications. British Journal of Clinical Pharmacology 57(1):6–14.

Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25998.
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McNeil, J. J., M. R. Nelson, R. L. Woods, J. E. Lockery, R. Wolfe, C. M. Reid, B. Kirpach, R. C. Shah, D. G. Ives, E. Storey, J. Ryan, A. M. Tonkin, A. B. Newman, J. D. Williamson, K. L. Margolis, M. E. Ernst, W. P. Abhayaratna, N. Stocks, S. M. Fitzgerald, S. G. Orchard, R. E. Trevaks, L. J. Beilin, G. A. Donnan, P. Gibbs, C. I. Johnston, B. Radziszewska, R. Grimm, A. M. Murray, and ASPREE Investigator Group. 2018. Effect of aspirin on all-cause mortality in the healthy elderly. New England Journal of Medicine 379(16):1519–1528.

Milton, J. C., I. Hill-Smith, and S. H. D. Jackson. 2008. Prescribing for older people. BMJ 336(7644):606–609.

Mitra, A., and F. Kesisoglou. 2013. Impaired drug absorption due to high stomach pH: A review of strategies for mitigation of such effect to enable pharmaceutical product development. Molecular Pharmaceutics 10(11):3970–3979.

Monaghesh, E., and A. Hajizadeh. 2020. The role of telehealth during COVID-19 outbreak: A systematic review based on current evidence. BMC Public Health 20(1193).

Mueller, M. 2004. Clinical, technical, and social contingencies and the decisions of adults with HIV/AIDS to enroll in clinical trials. Qualitative Health Research 14(5):704–713.

NCPA (National Community Pharmacists Association). 2020. Adherence research. https://ncpa.org/adherence-research (accessed November 12, 2020).

NIH (National Institutes of Health). 2018. Inclusion across the lifespan: June 12, 2017 workshop summary (revised July 2018). https://grants.nih.gov/policy/inclusion/lifespan.htm (accessed November 12, 2020).

Nobili, A., S. Garattini, and P. M. Mannucci. 2011. Multiple diseases and polypharmacy in the elderly: Challenges for the internist of the third millennium. Journal of Comorbidity 1(1):28–44.

Nogueira, R. G., A. P. Jadhav, D. C. Haussen, A. Bonafe, R. F. Budzik, P. Bhuva, D. R. Yavagal, M. Ribo, C. Cognard, R. A. Hanel, C. A. Sila, A. E. Hassan, M. Millan, E. I. Levy, P. Mitchell, M. Chen, J. D. English, Q. A. Shah, F. L. Silver, V. M. Pereira, B. P. Mehta, B. W. Baxter, M. G. Abraham, P. Cardona, E. Veznedaroglu, F. R. Hellinger, L. Feng, J. F. Kirmani, D. K. Lopes, B. T. Jankowitz, M. R. Frankel, V. Costalat, N. A. Vora, A. J. Yoo, A. M. Malik, A. J. Furlan, M. Rubiera, A. Aghaebrahim, J. M. Olivot, W. G. Tekle, R. Shields, T. Graves, R. J. Lewis, W. S. Smith, D. S. Liebeskind, J. L. Saver, T. G. Jovin, and DAWN Trial Investigators. 2017. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. New England Journal of Medicine 378(1):11–21.

NRC (National Research Council). 1990. Drug development for the geriatric population: Report of a workshop. Washington, DC: National Academy Press.

O’Sullivan, E. D., J. Hughes, and D. A. Ferenbach. 2017. Renal aging: Causes and consequences. Journal of the American Society of Nephrology 28(2):407–420.

Pillay, A. 2020. The barber-surgeons: Their history over the centuries. Hektoen International.https://hekint.org/2020/01/28/the-barber-surgeons-their-history-over-the-centuries (accessed November 12, 2020).

Powers, J. H., K. Howard, T. Saratsky, S. Clifford, S. Hoffmann, L. Llorens, and G. Talbot. 2016. Patient-reported outcome assessments as endpoints in studies in infectious diseases. Clinical Infectious Diseases 63(Suppl 2):S52–S56.

Powers, J. H., E. D. Bacci, N. K. Leidy, J. Poon, S. Stringer, M. J. Memoli, A. Han, M. P. Fairchok, C. Coles, J. Owens, W. Chen, J. C. Arnold, P. J. Danaher, T. Lalani, T. H. Burgess, E. V. Millar, M. Ridore, A. Hernández, P. Rodríguez-Zulueta, H. Ortega-Gallegos, A. Galindo-Fraga, G. M. Ruiz-Palacios, S. Pett, W. Fischer, D. Gillor, L. Moreno Macias, A. DuVal, R. Rothman, A. Dugas, and M. L. Guerrero. 2018. Performance of the inFLUenza Patient-Reported Outcome (FLU-PRO) diary in patients with influenza-like illness (ILI). PLoS One 13(3):e0914180.

Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25998.
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Radziszewska, B. 2019. New NIH inclusion policy promises better representation of research participants across the age spectrum. Inside NIA: A Blog for Researchers. https://www.nia.nih.gov/research/blog/2019/03/new-nih-inclusion-policy-promises-better-representation-research-participants (accessed November 12, 2020).

Rankin, A., C. A. Cadogan, S. M. Patterson, N. Kerse, C. R. Cardwell, M. C. Bradley, C. Ryan, and C. Hughes. 2018. Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database of Systematic Reviews 9:CD008165.

Releford, B. J., S. K. Frencher, Jr., A. K. Yancey, and K. Norris. 2010. Cardiovascular disease control through barbershops: Design of a nationwide outreach program. Journal of the National Medical Association 102(4):336–345.

Rubright, J. D., M. S. Cary, J. H. Karlawish, and S. Y. Kim. 2011. Measuring how people view biomedical research: Reliability and validity analysis of the Research Attitudes Questionnaire. Journal of Empirical Research on Human Research Ethics 6(1):63–68.

Sharma, N. S. 2015. Patient centric approach for clinical trials: Current trend and new opportunities. Perspectives in Clinical Research 6(3):134–138.

Singh, H., B. Kanapuru, C. Smith, L. A. Fashoyin-Aje, A. Myers, G. Kim, and R. Pazdur. 2017. FDA analysis of enrollment of older adults in clinical trials for cancer drug registration: A 10-year experience by the U.S. Food and Drug Administration. Journal of Clinical Oncology 35(15 Suppl):10009.

Squires, D., and C. Anderson. 2015. US health care from a global perspective, 2015: Spending, use of services, prices and health in 13 countries. The Commonwealth Fund.https://www.commonwealthfund.org/publications/issue-briefs/2015/oct/us-health-care-globalperspective (accessed November 12, 2020).

Sultana, J., P. Cutroneo, and G. Trifirò. 2013. Clinical and economic burden of adverse drug reactions. Journal of Pharmacology & Pharmacotherapeutics 4(Suppl 1):S73–S77.

Torres-Robles, A., E. Wiecek, F. S. Tonin, S. I. Benrimoj, F. Fernandez-Llimos, and V. Garcia-Cardenas. 2018. Comparison of interventions to improve long-term medication adherence across different clinical conditions: A systematic review with network meta-analysis. Frontiers in Pharmacology 9:1454.

Uldrick, U. S., G. Ison, M. A. Rudek, A. Noy, K. Schwartz, S. Bruinooge, C. Schenkel, B. Miller, K. Dunleavy, J. Wang, J. Zeldis, and R. F. Little. 2017. Modernizing clinical trial eligibility criteria: Recommendations of the American Society of Clinical Oncology–Friends of Cancer Research HIV Working Group. Journal of Clinical Oncology 35(33):3774–3780.

Verma, S. 2020. Early impact of CMS expansion of Medicare telehealth during COVID-19. Health Affairs Blog. https://www.healthaffairs.org/do/10.1377/hblog20200715.454789/ full (accessed November 12, 2020).

Vespa, J. 2018. The graying of America: More older adults than kids by 2035. The U.S. Census Bureau (revised October 8, 2019). https://www.census.gov/library/stories/2018/03/graying-america.html (accessed November 12, 2020).

Victor, R. G., K. Lynch, N. Li, C. Blyler, E. Muhammad, J. Handler, J. Brettler, M. Rashid, B. Hsu, D. Foxx-Drew, N. Moy, A. E. Reid, and R. M. Elashoff. 2018. A cluster-randomized trial of blood-pressure reduction in Black barbershops. New England Journal of Medicine 378(14):1291–1301.

Victor, R. G., C. A. Blyler, N. Li, K. Lynch, N. B. Moy, M. Rashid, L. C. Chang, J. Handler, J. Brettler, F. Rader, and R. M. Elashoff. 2019. Sustainability of blood pressure reduction in Black barbershops. Circulation 139:10–19.

Ward, K. T., and D. B. Reuben. 2020. Comprehensive geriatric assessment. UpToDate. https://www.uptodate.com/contents/comprehensive-geriatric-assessment (accessed November 11, 2020).

Warde, F., J. Papadakos, T. Papadakos, D. Rodin, M. Salhia, and M. Giuliani. 2018. Plain language communication as a priority competency for medical professionals in a globalized world. Canadian Medical Education Journal 9(2):e52–e59.

Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25998.
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Westbury, L. D., H. E. Syddall, N. R. Fuggle, E. M. Dennison, J. A. Cauley, E. J. Shiroma, R. A. Fielding, A. B. Newman, and C. Cooper. 2020. Long-term rates of change in musculoskeletal aging and body composition: Findings from the Health, Aging and Body Composition Study. Calcified Tissue International 106:616–624.

Williams, S. K., B. A. Johnson, J. N. Tobin, A. E. Luque, M. Sanders, J. K. Carroll, A. Cassells, T. Holder, and K. Fiscella. 2020. Protocol paper: Stepped wedge cluster randomized trial translating the ABCS into optimizing cardiovascular care for people living with HIV. Progress in Cardiovascular Diseases 63(2):125–133.

Williamson, J. D., M. A. Supiano, W. B. Applegate, D. R. Berlowitz, R. C. Campbell, G. M. Chertow, L. J. Fine, W. E. Haley, A. T. Hawfield, J. H. Ix, D. W. Kitzman, J. B. Kostis, M. A. Krousel-Wood, L. J. Launer, S. Oparil, C. J. Rodriguez, C. L. Roumie, R. I. Shorr, K. M. Sink, V. G. Wadley, P. K. Whelton, J. Whittle, N. F. Woolard, J. T. Wright, Jr., N. M. Pajewski, and SPRINT Research Group. 2016. Intensive vs. standard blood pressure control and cardiovascular disease outcomes in adults aged ≥75 years: A randomized clinical trial. JAMA 315(24):2673–2682.

Wright, W. A., J. M. Gorman, M. Odorzynski, M. J. Peterson, and C. Clayton. 2016. Integrated pharmacies at community mental health centers: Medication adherence and outcomes. Journal of Managed Care & Specialty Pharmacy 22(11):1330–1336.

Yu, J., J. H. Powers, D. Vallo, and J. Falloon. 2019. Evaluation of efficacy endpoints for a Phase IIb study of a respiratory syncytial virus vaccine in older adults using patient-reported outcomes with laboratory confirmation. Value Health 23(2):227–235.

Zimmerman, F. J., and N. W. Anderson. 2019. Trends in health equity in the United States by race/ethnicity, sex, and income, 1993–2017. JAMA Network Open 2(6):e196386.

Zulman, D. M., J. B. Sussman, X. Cen, C. T. Cigolle, C. S. Blaum, and R. A. Hayward. 2011. Examining the evidence: A systematic review of the inclusion and analysis of older adults in randomized controlled trials. Journal of General Internal Medicine 26(7):783–790.

Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25998.
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Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25998.
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Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25998.
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Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25998.
×
Page 93
Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25998.
×
Page 94
Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25998.
×
Page 95
Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25998.
×
Page 96
Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25998.
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Suggested Citation:"Appendix A: References." National Academies of Sciences, Engineering, and Medicine. 2021. Drug Research and Development for Adults Across the Older Age Span: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25998.
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There is a void in evidence-based information for making informed decisions on how to optimize care for older adults, particularly those 80 years and over. Because older adults are vastly underrepresented in clinical trials, there is a dearth of information about the appropriate use of drugs in this population. Yet older adults have higher rates of comorbidities and simultaneous use of multiple medications than the general population, and are the majority users of many medications. Additionally, age-related physiological and pathological changes, particularly for adults 80 years of age and older, can lead to significant differences in the pharmacokinetics (PK)2 and pharmacodynamics (PD)3 of a given drug compared to the general population.

On August 5 and 6, 2020, the National Academies of Sciences, Engineering, and Medicine hosted a workshop titled Drug Research and Development for Adults Across the Older Age Span. The workshop was designed to examine the challenges and opportunities in drug research and development for older adult populations, explore barriers that impede safety and efficacy studies in these populations, and share lessons learned for better understanding clinical pharmacology for populations over age 65. This publication summarizes the presentation and discussion of the workshop.

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