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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.
This project has been funded in whole with federal funds from the National Institutes of Allergy and Infectious Diseases, National Institutes of Health, under Contract No. N01-AI-45237. The views presented are those of the Institute of Medicine Committee to Study Priorities for Vaccine Development and are not necessarily those of the funding organization.
Library of Congress Cataloging-in-Publication Data
Institute of Medicine (U.S.). Committee to Study Priorities for Vaccine Development.
Vaccines for the 21st century: a tool for decisionmaking/Kathleen R.Stratton, Jane S.Durch, and Robert S.Lawrence, editors; Committee to Study Priorities for Vaccine Development, Division of Health Promotion and Disease Prevention, Institute of Medicine.
Includes bibliographical references and index.
ISBN 0-309-05646-2 (hard cover)
1. Vaccines—Research—United States—Planning. I. Stratton, Kathleen R. II. Durch, Jane. III. Lawrence, Robert S., 1938- IV. Title.
[DNLM: 1. Vaccines. 2. Economics, Pharmaceutical. 3. Models, Theoretical. 4. Research. QW 805 I592v 2000]
RA638 .I556 2000
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THE NATIONAL ACADEMIES
National Academy of Sciences
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National Research Council
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COMMITTEE TO STUDY PRIORITIES FOR VACCINE DEVELOPMENT
ROBERT S.LAWRENCE, M.D. (Chair), Associate Dean for Professional Education and Programs and Professor of Health Policy and Management,
Johns Hopkins School of Hygiene and Public Health
CAROL J.BAKER, M.D.,
Texas Children’s Hospital Foundation
Chair and Professor of Pediatrics, Microbiology, and Immunology and
Section of Infectious Diseases, Baylor College of Medicine
DAN W.BROCK, Ph.D., Charles C.Tillinghast, Jr.,
University Professor of Philosophy and Biomedical Ethics,
Center for Biomedical Ethics, Brown University
K.LYNN CATES, M.D., Associate Professor of Pediatrics,
Case Western Reserve University School of Medicine
ANNE A.GERSHON, M.D., Professor of Pediatrics,
College of Physicians and Surgeons, Columbia University
PETER M.HOWLEY, M.D., George Fabyan Professor and Chairman,
Department of Pathology, Harvard Medical School
SAMUEL L.KATZ, M.D., Wilburt C.Davison Professor and Chairman Emeritus,
Department of Pediatrics, Duke University Medical Center
JEFFREY KOPLAN, M.D., M.P.H.,* Executive Vice President and Director,
Prudential Center for Health Care Research, Atlanta
F.MARC LaFORCE, M.D., Professor of Medicine,
University of Rochester School of Medicine and Dentistry
JERRY R.McGHEE, Ph.D., Director,
Immunobiology Vaccine Center and
Professor of Microbiology,
University of Alabama at Birmingham
PEARAY L.OGRA, M.D., John Sealy Distinguished Chair and Professor of Pediatrics,
Children’s Hospital, University of Texas Medical Branch at Galveston
JUNE E.OSBORN, M.D., President,
Josiah Macy, Jr. Foundation, New York City
ELI E.SERCARZ, Ph.D., Professor Emeritus,
Department of Microbiology and Molecular Genetics, University of California at Los Angeles, and
Head and Member,
Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, San Diego
MILTON C.WEINSTEIN, Ph.D., Henry J.Kaiser Professor of Health Policy and Management,
Harvard School of Public Health
KATHLEEN STRATTON, Ph.D., Study Director
JANE DURCH, Program Officer
CYNTHIA HOWE, Program Officer
This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the National Research Council’s Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making the published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their participation in the review of this report:
Charles C.J.Carpenter, M.D., Brown University;
Gordon DeFriese, Ph.D., University of North Carolina at Chapel Hill;
Roger D.Feldman, Ph.D., University of Minnesota;
Harvey V.Fineberg, M.D., Ph.D., Harvard University;
Fernando Guerra, M.D., M.P.H., San Antonio Metropolitan Health District;
Michael Katz, M.D., March of Dimes Birth Defects Foundation;
Louis Lasagna, M.D., Tufts University School of Medicine; and
Henry W.Riecken, Ph.D., University of Pennsylvania.
While the individuals listed above have provided constructive comments and suggestions, it must be emphasized that responsibility for the final content of this report rests entirely with the authoring committee and the institution.