SMART Vaccines--Strategic Multi-Attribute Ranking Tool for Vaccines--is a prioritization software tool developed by the Institute of Medicine that utilizes decision science and modeling to help inform choices among candidates for new vaccine development. A blueprint for this computer-based guide was presented in the 2012 report Ranking Vaccines: A Prioritization Framework: Phase I.
Ranking Vaccines: A Prioritization Software Tool,Phase II extends the proof-of-concept presented in the Phase I report, which was based on multi-attribute utility theory. This report refines a beta version of the model developed in the Phase I report and presents its next iteration, SMART Vaccines 1.0.
Ranking Vaccines: Phase II discusses the methods underlying the development, validation, and evaluation of SMART Vaccines 1.0. It also discusses how SMART Vaccines should--and, just as importantly, should not--be used. The report also offers ideas for future enhancements for SMART Vaccines as well as for ideas for expanded uses and considerations and possibilities for the future.
Table of Contents
|1 Introduction: New Vaccines and SMART Vaccines||13-24|
|2 Refinements to the SMART Vaccines Model||25-32|
|3 Data Synthesis, Software Redesign, and Evaluation||33-60|
|4 Observations and Looking Forward||61-70|
|Appendix A: Computational Modeling for SMART Vaccines||73-84|
|Appendix B: Candidate Disease Profiles||85-98|
|Appendix C: Data Sources and Methodology for SMART Vaccines||99-110|
|Appendix D: Verification and Analyses of the SMART Vaccines Computational Model||111-124|
|Appendix E: Stakeholder Speakers||125-126|
|Appendix F: Biographical Information||127-142|
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