The very rapid pace of advances in biomedical research promises us a wide range of new drugs, medical devices, and clinical procedures. The extent to which these discoveries will benefit the public, however, depends in large part on the methods we choose for developing and testing them.
Modern Methods of Clinical Investigation focuses on strategies for clinical evaluation and their role in uncovering the actual benefits and risks of medical innovation.
Essays explore differences in our current systems for evaluating drugs, medical devices, and clinical procedures; health insurance databases as a tool for assessing treatment outcomes; the role of the medical profession, the Food and Drug Administration, and industry in stimulating the use of evaluative methods; and more.
This book will be of special interest to policymakers, regulators, executives in the medical industry, clinical researchers, and physicians.
Table of Contents
|1. Medical Technology Development: An Introduction to the Innovation-Evaluation Nexus||1-15|
|2. The Selection of Endpoints in Evaluation Research||16-22|
|3. Advances in Health Status Measurement: The Potential to Improve Experimental and Non-Experimental Data Collection||23-32|
|4. What is Outcomes Research?||33-46|
|5. Strengths and Weaknesses of Health Insurance Data Systems for Assessing Outcomes||47-67|
|6. Perscription-Event Monitoring: An Example of Total Population Post-Marketing Drug Serveillance||68-77|
|7. The Role of Decision Analysis in the Translation of Research Findings into Clinical Practice||78-87|
|8. Meta-Analysis: A Quantitative Approach to Research Integration||88-100|
|9. An Introduction to a Bayesian Method for Meta-Analysis: The Confidence Profile Method||101-116|
|10. Should We Change the Rules for Evaluating Medical Technologies?||117-134|
|11. Attitudinal Factors That Influence the Utilization of Modern Evaluative Methods||135-146|
|Appendix A: Comparing the Development of Drugs, Devices, and Clinical Procedures||147-201|
|Appendix B: Workshop Agenda||202-205|
|Appendix C: Contributors||206-212|
The National Academies Press (NAP) has partnered with Copyright Clearance Center's Rightslink service to offer you a variety of options for reusing NAP content. Through Rightslink, you may request permission to reprint NAP content in another publication, course pack, secure website, or other media. Rightslink allows you to instantly obtain permission, pay related fees, and print a license directly from the NAP website. The complete terms and conditions of your reuse license can be found in the license agreement that will be made available to you during the online order process. To request permission through Rightslink you are required to create an account by filling out a simple online form. The following list describes license reuses offered by the National Academies Press (NAP) through Rightslink:
Click here to obtain permission for the above reuses. If you have questions or comments concerning the Rightslink service, please contact:
Rightslink Customer Care
Tel (toll free): 877/622-5543
To request permission to distribute a PDF, please contact our Customer Service Department at 800-624-6242 for pricing.
To request permission to translate a book published by the National Academies Press or its imprint, the Joseph Henry Press, please click here to view more information.