Clinical Applications of Mifepristone (RU486) and Other Antiprogestins:

Assessing the Science and Recommending a Research Agenda

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Size: 304 pages, 6 x 9

Publication Year:1993

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Authors:
Molla S. Donaldson, Laneta Dorflinger, Sarah S. Brown, and Leslie Z. Benet, Editors; Committee on Antiprogestins: Assessing the Science, Institute of Medicine
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Description:
Mifepristone (RU486), the first clinically available antiprogestin, has generated great interest since its discovery in the early 1980s. Today, it is recognized that mifepristone, along with other antiprogestins, has a potentially significant therapeutic role in human health and disease, with ...
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Table of Contents
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Front Matter	i-xiv
Summary	1-13	(skim)
INtroduction	14-18	(skim)
Uses of Antiprogestins: The Reproductive Cycle (Part I)	19-25	(skim)
Uses of Antiprogestins: The Reproductive Cycle (Part II)	26-35	(skim)
Other Therapeutic Uses of Antiprogestins	36-51	(skim)
Antiglucocorticoid Effects of Antiprogestins	52-56	(skim)
Animals as Models for Studying Antiprogestins	57-62	(skim)
Appendix A: Agenda fr the IOM Workshop 'Antiprogestins: Assessing the Science'	63-68	(skim)
Appendix B: Background Papers and Presentations (In Order of Presentation at IOM Workshop)	69-70	(skim)
B1. 1993: RU 486--A Decade on Today and Tomorrow	71-119	(skim)
B2. Overview and Background: Mechanism of Action of Antiprogestins	120-138	(skim)
B3. The Use of Antiprogestins in the Reproductive Cycle	139-147	(skim)
B4. Potential Contraceptive Effects of Antigestogens	148-163	(skim)
B5. Use of Antiprogestins Before 63 Days of Amenorrhea	164-173	(skim)
B6. Uses of Antiprogestins After 63 Days of Amenorrhea	174-182	(skim)
B7. Comments on Session II	183-188	(skim)
B8. Use of Antiprogestins in the Management of Endometriosis and Leiomyoma	189-209	(skim)
B9. Antiprogestins and the Treatment of Breast Cancer	210-228	(skim)
B10. Uses of RU 486 as an Antiglucocoticoid	229-242	(skim)
B11. Primate Models for the Study of Antiprogestins in Reproductive Medicine	243-252	(skim)
B12. ANtiprogestogens: Perspectives from a Global Research Program	253-277	(skim)
Appendix C: Observers at the Workshop on Antiprogestins	278-280	(skim)
Index	281-288	(skim)

Description

Mifepristone (RU486), the first clinically available antiprogestin, has generated great interest since its discovery in the early 1980s. Today, it is recognized that mifepristone, along with other antiprogestins, has a potentially significant therapeutic role in human health and disease, with likely applicability to a variety of pregnancy-related conditions (e.g., management of labor) and to contraception, endometriosis, and cancer, among others. But because mifepristone has been studied and used most widely as a means of nonsurgical abortion, political issues have thus far limited research on the drug and prevented its introduction into the U.S. market.
This book provides an unbiased evaluation of current knowledge about both the fundamental nature of antiprogestins as well as their possible use in treating numerous diseases and conditions, and it contains recommendations for future research.

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Institute of Medicine (IOM)

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