The model for risk assessment of nutrients used to develop tolerable upper intake levels (ULs) is one of the key elements of the developing framework for Dietary Reference Intakes (DRIs). DRIs are dietary reference values for the intake of nutrients and food components by Americans and Canadians. The U.S. National Academy of Sciences recently released two reports in the series (IOM, 1997, 1998). The overall project is a comprehensive effort undertaken by the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes (DRI Committee) of the Food and Nutrition Board (FNB), Institute of Medicine, National Academy of Sciences in the United States, with active involvement of Health Canada. The DRI project is the result of significant discussion from 1991 to 1996 by the FNB regarding how to approach the growing concern that one set of quantitative estimates of recommended intakes, the Recommended Dietary Allowances (RDAs), was scientifically inappropriate to be used as the basis for many of the uses to which it had come to be applied.
Table of Contents
|What Are Dietary Reference Intakes?||2-4|
|Approach for Setting Dietary Reference Intakes, Including Tolerable Upper Intake Levels||5-5|
|Model for the Derivation of Tolerable Upper Intake Levels||6-6|
|Risk Assessment and Food Safety||7-9|
|Application of the Risk Assessment Model to Nutrients||10-13|
|Steps in the Development of the Tolerable Upper Intake Level||14-19|
|Derivation of ULs: Summary of Progress to Date||20-23|
|Appendix A: Recommended Dietary Intakes for Individuals||27-30|
|Appendix B: Options for Dealing with Uncertainties||31-34|
|Appendix C: Reference Heights and Weights for Children and Adults||35-36|
|Appendix D: Case Studies of Application of Risk Assessment Model for Nutrients||37-66|
|Appendix E: Biographical Sketches of Subcommittee on Upper Reference Levels of Nutrients||67-71|
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