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Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of the 1999 US/Japan Conference
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Microbial Status and Genetic Evaluation of Mice and Rats:
Proceedings of the 1999 US/Japan Conference
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US/Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US/Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes. In addition to these publications, the meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats.

In cooperation with the Comparative Medicine section of NCRR/NIH, the ILAR Council and staff are pleased to become the host for this important annual meeting and look forward to participating in future meetings. The support and sponsorship of NCRR (P40 RR 11611) in the United States and the Central Institute for Experimental Animals in Japan are gratefully acknowledged. Bringing together the leading scientists in the field of laboratory animal care has resulted in increased understanding of American and Japanese approaches to laboratory animal science and should continue to strengthen efforts to harmonize approaches aimed at resolving common challenges in the use of animal models for biomedical research and testing. This effort to improve understanding and cooperation between Japan and the United States should also be useful in developing similar interaction with other regions of the world including Europe, Australia, and Southeast Asia.


Publication Info

166 pages | 6 x 9
ISBN: 978-0-309-07357-8

Table of Contents

skim chapter
Front Matter i-xvi
Opening Remarks, Judith Vaitukaitis 1-3
Opening Remarks, Shin-Ichi Ota 4-5
Introductory Comments on Microbiologic Testing of Laboratory Mice and Rats: Uniformity of Results 6-6
Development of a Performance Assessment Program for Research Animal Diagnostic Laboratories and Defining Microbiologic Testing Standards 7-10
Standardization of Rodent Health Surveillance: Regulation Versus Competition 11-15
Factors Causing Difficulties in Uniformity of Results Among Testing Facilities in Microbiologic Monitoring of Laboratory Animals 16-20
Necessity of Reexamining the Pathogenicity and Elimination of Parasites in Rats and Mice 21-26
Emerging (and Reemerging) Viruses of Laboratory Mice and Rats 27-34
Emerging Infections as a Cause of Concern 35-39
Emerging Diseases in Mice and Rats 40-43
Survey of Heliobacter Species in Laboratory Mice and Gerbils in Japan 44-46
Genetic Evaluation of Outbred Rats 47-50
Genetic Evaluation of Outbred Rats from the Breeder's Perspective 51-64
Concept for Establishment of Rat Outbred Global Standard Strains 65-76
Necessity of Genetic and Microbiologic Quality Network from the Pharmaceutical Industry's Perspective 77-84
International Harmonization of Laboratory Animals 85-96
Rat Genetics and Toxicology 97-104
A Phenotype-driven Approach to the Molecular and Functional Analysis of the Mouse Genome 105-115
Evaluation of Targeted Mutations 116-118
Defining Behavioral Phenotypes in Transgenic and Knockout Mice 119-129
Defining Phenotype in Genetically Engineered Mice 130-131
Development of the Mouse Model Dramatype for Human Clinical Benefit 132-136
Concluding Remarks 137-137
Implication of Wild-derived Genes, Mitochondria, and Chromosomes in the Genetic Background of Mouse Models for Diseases and Biologic Functions 138-141
Concluding Comments, John Strandberg 142-143
Concluding Remarks, John Vandenbergh 144-146
Appendix A 147-148
Appendix B 149-150

Suggested Citation

National Research Council. Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of the 1999 US/Japan Conference. Washington, DC: The National Academies Press, 2000.

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