TABLE 2–2 Critical Path Roadmap Project: Critical Risks. SOURCE: Charles, 2000

Bone Loss

Cardiovascular Alterations

Human Behavior and Performance

Immunology, Infection and Hematology

Muscle Alterations and Atrophy

Acceleration of age-related osteoporosis


Human performance failure because of poor psychosocial adaptation



Fractures (traumatic, stress, avulsion), and impaired healing of fractures

Occurrence of serious cardiac dysrhythmias

Human performance failure because of sleep and circadian rhythm problems


Loss of skeletal muscle mass, strength, or endurance


Impaired cardiovascular response to orthostatic stress


Inability to adequately perform tasks due to motor performance problems, poor muscle endurance, and disruptions in structural and functional properties of soft and hard connective tissues of the axial skeleton


Inability to sustain muscle performance levels to meet demands of performing activities of various intensities

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