measures for pathophysiological changes including those that are associated with aging; and the care of astronauts during space missions.

The strategic research plan should be systematic, prospective, comprehensive, periodically reviewed and revised, and transparent to the astronauts, the research community, and the public. It should focus on

  • providing an understanding of basic pathophysiological mechanisms by a systems approach;

  • using the International Space Station as the primary test bed for fundamental and human-based biological and behavioral research;

  • using more extensively analog environments that already exist and that have yet to be developed;

  • using the research strengths of the federal government, universities, and industry, including pharmaceutical, bioengineering, medical device, and biotechnology firms; and

  • developing the health care system for astronauts as a research database.

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