Appendix C
ABBREVIATIONS


Ahr

aryl hydrocarbon receptor

ADH

alcohol dehydrogenase


cDNA

complementary deoxyribonucleic acid

CYP1B1

cytochrome P450, isozyme 1B1

CYP2A6

cytochrome P450, isozyme 2A6

CYP2E1

cytochrome P450, isozyme 2E1

CYP3A4

cytochrome P450, isozyme 3A4


DNA

deoxyribonucleic acid


EH

epoxide hydrolase

EPA

U.S. Environmental Protection Agency

E2

Estrogen


FDA

U.S. Food and Drug Administration


GAO

U.S. Government Accountability Office

GST

glutathione S-transferase


IARC

International Agency for Research on Cancer

IGFbp5

insulin-like growth factor-binding protein-5


LOX

lysyl oxidase


MOA

mode-of-action

mRNA

messenger ribonucleic acid

MTD

maximal tolerated dose



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Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens: A Workshop Summary Appendix C ABBREVIATIONS Ahr aryl hydrocarbon receptor ADH alcohol dehydrogenase cDNA complementary deoxyribonucleic acid CYP1B1 cytochrome P450, isozyme 1B1 CYP2A6 cytochrome P450, isozyme 2A6 CYP2E1 cytochrome P450, isozyme 2E1 CYP3A4 cytochrome P450, isozyme 3A4 DNA deoxyribonucleic acid EH epoxide hydrolase EPA U.S. Environmental Protection Agency E2 Estrogen FDA U.S. Food and Drug Administration GAO U.S. Government Accountability Office GST glutathione S-transferase IARC International Agency for Research on Cancer IGFbp5 insulin-like growth factor-binding protein-5 LOX lysyl oxidase MOA mode-of-action mRNA messenger ribonucleic acid MTD maximal tolerated dose

OCR for page 54
Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens: A Workshop Summary NIEHS National Institute of Environmental Health Sciences NIH National Institutes of Health NOAEL no-observed-adverse-effects level OHT 4-hydroxytamoxifen OPN osteopontin PCR polymerase chain reaction PGME propylene glycol monomethyl ether RNA ribonucleic acid SAR structure-activity relationship SNP single-nucleotide polymorphisms

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Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens: A Workshop Summary This page intentionally left blank.