Humans spend about one-third of their lives asleep, yet most individuals know little about sleep. Although its function remains to be fully elucidated, sleep is a universal need of all higher life forms including humans, absence of which has serious physiological consequences. This chapter provides an overview of basic sleep physiology and describes the characteristics of REM and NREM sleep. Sleep and circadian-generating systems are also reviewed. The chapter ends with a discussion about how sleep patterns change over an individual’s life span.

SLEEP ARCHITECTURE

Sleep architecture refers to the basic structural organization of normal sleep. There are two types of sleep, non-rapid eye-movement (NREM) sleep and rapid eye-movement (REM) sleep. NREM sleep is divided into stages 1, 2, 3, and 4, representing a continuum of relative depth. Each has unique characteristics including variations in brain wave patterns, eye movements, and muscle tone. Sleep cycles and stages were uncovered with the use of electroencephalographic (EEG) recordings that trace the electrical patterns of brain activity (Loomis et al., 1937; Dement and Kleitman, 1957a).

Two Types of Sleep

Over the course of a period of sleep, NREM and REM sleep alternate cyclically (Figure 2-1). The function of alternations between these two types of sleep is not yet understood, but irregular cycling and/or absent sleep stages are associated with sleep disorders (Zepelin et al., 2005). For example, instead of entering sleep through NREM, as is typical, individuals

FIGURE 2-1 Progression of sleep states across a single night in young adult.

SOURCE: Carskadon and Dement (2005).



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