generalizability to humans, 133-134, 135-136

genetics, 73, 136, 142-144

house sparrows, 133

immune function, 134, 136-137, 138-139, 141, 143-144

knockout models, 142, 149, 330

limitations, 135-136

mediating variables, 137

modeling known interactions and diseases in humans, 133-134

moderating variables, 137

Morris water maze, 135

nicotine addiction, 70, 79

nonhuman primates, 133, 140, 141, 142, 145-146

nontraditional animal models, 134

obesity, 73, 267

physiology, 136-137

psychosocial traits, 133, 135-136, 144

rationale, 132-133

recommendations, 7, 150

rodent models, 133, 135, 138, 140, 141-142, 144, 145-146, 147, 149

role, 132-136

side-blotch lizards, 138-139

social affiliation and support, 141, 142

social isolation, 133, 138, 141-142

social status, 133, 144-146

social stressors, 145, 146-147

stress responsivity, 135, 137, 142-144, 145, 146-148

temperament, 140-141

Antioxidant regulatory element, 51

Apolipoprotein E protein polymorphisms, 61, 76, 214

Appetite, 257, 258, 267, 268

Arginine vasopressin, 118, 146

Arthritis, 143

Ashkenazi Jews, 38, 100, 101, 149

Asthma, 137

Ataxia telangiectasia, 149

Atherosclerosis, 118, 119, 147, 298, 302

Atopic dermatitis, 144

Attention Deficit Hyperactivity Disorder, 80

Autoimmune disease, 137, 142-144

B

Bardet-Biedel syndrome, 73, 255

Bayesian belief networks, 65

Behavioral factors.

See also Eating behaviors;

Health risk behaviors;

Physical inactivity;

Tobacco use

context for interaction studies, 22, 125

CVD, 57, 58, 70, 73

obesity, 245-251

peer and family influences, 71

and psychological response and physiological processes, 116-122

β2-AR, β3-AR genes, 137, 257, 264, 305

β-Endorphins, 301

β-Thalassemia, 54-55, 101, 284

Binge Eating Disorder, 261

Biochemical System Theory, 123

Biochemical systems and processes.

See also Metabonomics;

Proteomics

affiliative behavior and, 36, 145

genomic information embedded in, 114-116

modeling, 123

psychological response to social factors and, 21, 116-122

stress and, 117-122

Bioinformatics, 51

Biologic interaction, 311, 317, 322

Biology, hierarchical view, 123

Biomedical model, 281-282

Biomedical research, 15, 18, 133-134

Biomolecular Interaction Network Database, 124

Biopsychosocial model, 282, 283, 297

Birth defects, 47

Blood lead levels, 27

Bloom syndrome, 101

BMP6 gene, 288

Body Mass Index (BMI), 69, 72, 73, 238, 250, 252, 253-257, 263.

See also

Obesity

Bowlby, John, 34

Breast cancer, 35, 38, 46, 59, 73, 101, 141, 149, 174

C

C-reactive protein, 76, 171-172, 191

Cadmium, 114

Canavan’s syndrome, 101

Cancer

animal research, 149

biomarkers, 115

depression and, 80



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