Priorities for Study

Abstract: The Institute of Medicine Committee on Comparative Effectiveness Research Prioritization was charged with developing a portfolio of priority topics that reflected balance across research areas, populations, type of interventions, and methodologies. The final list of 100 priority CER topics includes a large number addressing health care delivery systems, and a large number that consider racial and ethnic disparities. All but 3 of the 32 originally delineated research areas are represented. Similarly, the priority research topics include studies examining various special population categories, including individuals with rare diseases. This chapter presents the full list of priority CER topics.

As explained in detail in Chapter 1, the Institute of Medicine (IOM) committee’s statement of task charged the committee with developing a list of priority comparative effectiveness research (CER) topics and presenting those recommendations for the Secretary to consider. To develop the list, the committee obtained substantial public input (described in Chapter 3) and followed a multistage process of individual and collective deliberation (described in Chapter 4). The final portfolio, described in this chapter, contains 100 priority topics. The first half of the chapter is a “portfolio analysis,” which shows the representation of research areas, study populations, comparators, and study methodologies within the final 100 topics. The second half of the chapter presents the specific CER topics prioritized by the committee, together with a description of their relevance.

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