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Proceedings of the National Academy of Sciences of the United States of America PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Table of Contents Papers from a National Academy of Sciences Colloquium: Genetic Engineering of Viruses and Viral Vectors Genetic engineering of viruses and of virus vectors: A preface Peter Palese and Bernard Roizman 11287 Site-specific integration by adeno-associated virus R.Michael Linden, Peter Ward, Catherine Giraud, Ernest Winocour, and Kenneth I.Berns 11288–11294 Oncogenic potential of the adenovirus E4orf6 protein Mary Moore, Nobuo Horikoshi, and Thomas Shenk 11295–11301 Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma Manuel Caruso, Khiem Pham-Nguyen, Yok-Lam Kwong, Bisong Xu, Ken-Ichiro Kosai, Milton Finegold, Savio L.C.Woo, and Shu-Hsia Chen 11302–11306 The function of herpes simplex virus genes: A primer for genetic engineering of novel vectors Bernard Roizman 11307–11312 The application of genetically engineered herpes simplex viruses to the treatment of experimental brain tumors Samita S.Andreansky, Bin He, G.Yancey Gillespie, Liliana Soroceanu, James Markert, Joany Chou, Bernard Roizman, and Richard J.Whitley 11313–11318 Replication-defective herpes simplex virus vectors for gene transfer in vivo Peggy Marconi, David Krisky, Thomas Oligino, Pietro L.Poliani, Ramesh Ramakrishnan, William F.Goins, David J.Fink, and Joseph C.Glorioso 11319–11320 A deletion mutant in the human cytomegalovirus gene encoding IE1491aa is replication defective due to a failure in autoregulation Edward S.Mocarski, George W.Kemble, John M. Lyle, and Richard F.Greaves 11321–11326 Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains Thomas R.Jones, Emmanuel J.H.J.Wiertz, Lei Sun, Kenneth N.Fish, Jay A.Nelson, and Hidde L.Ploegh 11327–11333 Epstein-Barr virus vectors for gene delivery to B lymphocytes Erle S.Robertson, Tadamasa Ooka, and Elliott D.Kieff 11334–11340 Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety Bernard Moss 11341–11348 Applications of pox virus vectors to vaccination: An update Enzo Paoletti 11349–11353
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Proceedings of the National Academy of Sciences of the United States of America Negative-strand RNA viruses: Genetic engineering and applications Peter Palese, Hongyong Zheng, Othmar G. Engelhardt, Stephan Pleschka, and Adolfo García-Sastre 11354–11358 Foreign glycoproteins expressed from recombinant vesicular stomatitis viruses are incorporated efficiently into virus particles Matthias J.Schnell, Linda Buonocore, Evelyne Kretzschmar, Erik Johnson, and John K.Rose 11359–11365 Specific infection of CD4+ target cells by recombinant rabies virus pseudotypes carrying the HIV-1 envelope spike protein Teshome Mebatsion and Karl-Klaus Conzelmann 11366–11370 Alphavirus-based expression vectors: Strategies and applications Ilya Frolov, Thomas A.Hoffman, Béla M.Prágai, Sergey A.Dryga, Henry V.Huang, Sondra Schlesinger, and Charles M.Rice 11371–11377 Early events in poliovirus infection: Virus-receptor interactions Vincent R.Racaniello 11378–11381 Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector Luigi Naldini, Ulrike Blömer, Fred H.Gage, Didier Trono, and Inder M.Verma 11382–11388 Use of virion DNA as a cloning vector for the construction of mutant and recombinant herpesviruses S.Monroe Duboise, Jie Guo, Ronald C.Desrosiers, and Jae U.Jung 11389–11394 Development of HIV vectors for anti-HIV gene therapy Eric Poeschla, Pierre Corbeau, and Flossie Wong-Staal 11395–11399 A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes Daniel S.Ory, Beverly A.Neugeboren, and Richard C.Mulligan 11400–11406 Cell-surface receptors for retroviruses and implications for gene transfer A.Dusty Miller 11407–11413 Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces protective immunity in animal models of herpes simplex virus-2 disease William L.McClements, Marcy E.Armstrong, Robert D.Keys, and Margaret A.Liu 11414–11420 Fusigenic viral liposome for gene therapy in cardiovascular diseases Victor J.Dzau, Michael J.Mann, Ryuichi Morishita, and Yasufumi Kaneda 11421–11425