TABLE 5-1 Effect of Vitamin C Supplementation on Biomarkers of Lipid Oxidation in Humans

Reference

Subjects

Vitamin C Dosea (mg/d)

Harats et al., 1990

17 smokers

1,000

1,500

Belcher et al., 1993

5 healthy men

1,000

Rifici and Khachadurian, 1993

4 healthy men and women

1,000

Cadenas et al., 1996

21 healthy men

1,000

Fuller et al., 1996

19 smokers

(9 placebo)

1,000

Mulholland et al., 1996

16 female smokers

(8 placebo)

1,000

Reilly et al., 1996

5 heavy smokers

2,000

Anderson et al., 1997

48 nonsmokers

(24 females)

60

6,000

Nyyssonen et al., 1997b

59 male smokers

(19 placebo)

500 (Pj)

500 (SRk)

Samman et al., 1997

8 male smokers

(40)

1,000

Wen et al., 1997

20 nonsmokers

(9 placebo)

1,000

Harats et al., 1998

36 healthy men

(50)

500 (citrus fruit supplement)

Naidoo and Lux, 1998

9 healthy men, 6 healthy women

250, 500, 750 and 1,000

a Amount given in excess of variable amount consumed daily as part of the diet.

b LDL = low-density lipoprotein.

c TBARS = thiobarbituric acid reactive substances.

d LDL oxidizability is measured by the lag time and propagation rate of in vitro lipid peroxidation.

e VLDL = very low-density lipoprotein.

f CD = conjugated dienes.



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