TABLE 5-2 Vitamin C Intake and Biomarkers of Gastric and Bladder Cancer

Reference

Subjects

Vitamin C Dose (mg/d)

Leaf et al., 1987

7 men

2–1,000

Young et al., 1990

18 healthy men

1,500

Dyke et al., 1994a

43 patients with gastritis

1,000

Dyke et al., 1994b

48 patients with gastritis

1,000

Drake et al., 1996

82 patients with dyspepsia

None

Mannick et al., 1996

84 patients with Helicobacter pylori infection

2,000

Satarug et al., 1996

31 healthy men, 80 men with liver fluke infection

300 with 300 mg/d proline

a DNA = deoxyribonucleic acid.

b ROS = Reactive Oxygen Species.

c RNS = Reactive Nitrogen Species.

TABLE 5-3 Vitamin C and Endothelium-Dependent Vasodilation in Humans

Reference

Subjects

Heitzer et al., 1996

10 chronic smokers

10 control subjects

Levine et al., 1996

46 coronary artery disease patients

(20 placebo)

Ting et al,, 1996

10 type II diabetic patients

10 control subjects

Motoyama et al., 1997

20 smokers

20 control subjects

Solzbach et al., 1997

22 hypertensive patients

Ting et al., 1997

11 hypercholesterolemic patients

12 healthy control subjects

Hornig et al., 1998

15 chronic heart failure patients

8 healthy control subjects

Taddei et al., 1998

14 hypertensive patients

14 healthy control subjects

Timimi et al., 1998

10 type I diabetic patients

10 control subjects



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