Implications of Genomics for Public Health
Workshop Summary
Lyla M. Hernandez, Editor
THE NATIONAL ACADEMIES PRESS
Washington, D.C.
www.nap.edu
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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.
This study was supported by Contract No. 200N01-OD-4-2139 between the National Academy of Sciences and the Agency for Health Care Research and Quality, National Institutes of Health. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project.
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COMMITTEE ON GENOMICS AND THE PUBLIC’S HEALTH IN THE 21ST CENTURY
LAWRENCE O. GOSTIN, J.D., L.L.D. (HON.) (Chair), Professor of Law, Director,
Center on Law and the Public’s Health, Georgetown University,
Professor of Public Health,
Johns Hopkins University
MELISSA AUSTIN, M.S., PH.D., Professor of Epidemiology, Director,
Institute for Public Health Genetics, University of Washington
DEBORAH BOWEN, PH.D., Associate Affiliate Professor,
Fred Hutchinson Cancer Research Center, University of Washington
ELLEN WRIGHT CLAYTON, M.D., J.D., Rosalind E. Franklin Professor of Genetics and Health Policy, Director of Genetics and Health Policy Center, Senior Fellow,
Institute for Public Policy Studies,
Professor of Law and Pediatrics,
Vanderbilt University
IRVING GOTTESMAN, PH.D., Professor in Adult Psychiatry, Senior Fellow,
Department of Psychology, University of Minnesota, Twin Cities
KAREN GREENDALE, M.A., C.G.C., Director,
Genetics Education and Information Program, Bureau of Chronic Disease Services, New York State Department of Health
SHARON L.R. KARDIA, PH.D., Associate Professor,
Department of Epidemiology,
Director,
Public Health Genetics Program, University of Michigan School of Public Health
DAVID NERENZ, PH.D., Senior Staff Investigator,
Center for Health Services Research, Henry Ford Health System
KENNETH OFFIT, M.D., Chief,
Clinical Genetics Service, Department of Human Genetics, Memorial Sloan-Kettering Cancer Center
DAVID L. RIMOIN, M.D., PH.D., Steven Spielberg Chairman of Pediatrics, Director,
Medical Genetics–Birth Defects Center, Cedars-Sinai Medical Center,
Professor of Pediatrics, Medicine & Human Genetics,
David Geffen School of Medicine at University of California, Los Angeles
DAVID L. VEENSTRA, PHARM.D., PH.D., Assistant Professor,
Department of Clinical Pharmacy, University of California at San Francisco
DEBORAH KLEIN WALKER, ED.D., Principal Associate,
Abt Associates, Inc.
Liaison to the Board on Health Promotion and Disease Prevention
GEORGE J. ISHAM, M.D.,
HealthPartners, Inc.
Staff
LYLA M. HERNANDEZ, Study Director
MAKISHA WILEY, Senior Program Assistant
ROSE MARIE MARTINEZ, SC.D., Director,
Board on Health Promotion and Disease Prevention
Reviewers
This report has been reviewed in draft form by persons chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the National Research Council Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following for their review of this report:
MICHAEL ERIKSEN, Georgia State University
ROXANNE PARROTT, PH.D., Pennsylvania State University
BERNIE ROSOF, M.D. F.A.C.P., North Shore Long Island Jewish Health System
DONNA SPOON, Health Director’s Office
Although the reviewers listed above have provided many constructive comments and suggestions, they were not asked to endorse the final draft of the report before its release. The review of this report was overseen by ROBERT B. WALLACE, M.D., College of Public Health, University of Iowa. He was responsible for making certain that an independent examination of this report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this report rests entirely with the author committee and the institution.
Contents
Opening Remarks, |
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Keynote: Genomics and Public Health: A Vision for the Future, |
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The Science of Genomics |
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The Science of Genomics and Its Application to Common Diseases, |
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Bridging Genomics and Population Health, |
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Gene–Environment Interactions, |
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Genomics in Practice |
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Clinical Use of Genomic Information, |
Cost-Effectiveness Analysis in Decision Making, |
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Intersection of Genomic Information and Behavioral Sciences, |
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How to Effect Change in the Population, |
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Keynote: Stratification, Justice, and Opportunity, |
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Genomics and Public Health |
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The Public Health System, |
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International Lessons: Biobanks, |
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Educating the Public, |
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Capacity, |
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Genomic Information and Its Application to Population Health, |
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Financing and Access, |
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Legal and Regulatory, |
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Workshop Overview: Lessons Learned, Places to Go, |
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