Skip to main content

Definition of Pain and Distress and Reporting Requirements for Laboratory Animals Proceedings of the Workshop Held June 22, 2000 (2000) / Chapter Skim
Currently Skimming:

On Regulating Pain and Distress
Pages 58-62

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 58...
... and Molly Greenet * Department of Pharmacology and [Institutional Animal Care Program University of Texas Health Science Center San Antonio, Tex.
Read the entire page →
From page 59...
... The Animal Welfare Act contains the following very simple statement: "The Secretary shall promulgate standards for animal care, treatment and practices in experimental procedures to insure that animal pain and distress are minimized, including adequate veterinary care with appropriate use of anesthetic, analgesic, or tranquilizing drugs or euthanasia." This simple statement has been made more complex than necessary. The most effective means of minimizing pain and distress in research animals is not by federal regulation, but by an emphasis on the shared responsibility
Read the entire page →
From page 60...
... Pain and distress are considered in depth during the development of experimental protocols including veterinary prereview, IACUC review, and peer review by funding agencies and often by institutions. After protocols are approved and the work begins, animals are monitored throughout the study by animal care staff, research staff, and laboratory animal veterinarians.
Read the entire page →
From page 61...
... ETHICAL ISSUES My final message addresses the relation between biomedical research and the ethics of animal use. Jerrold Tannenbaum of the University of California, Davis, said at the PRIMER meeting this spring, "Ethical issues in science are determined by advances in science." In other words, complex diseases and complex approaches to understanding disease often raise ethical questions pertaining to science.
Read the entire page →
From page 62...
... In other words, the field of physiological genomics will likely require an even greater use of animals in research. Again, it will be a shared responsibility in which the increasingly complex animal models of disease will mandate that investigators, veterinarians, and IACUCs have a greater responsibility ensuring animal well-being.
Read the entire page →

Key Terms

  • animal care
  • animal welfare
  • laboratory animal
  • animal models
  • welfare act

  • animal veterinarians
  • shared responsibility
  • ensuring animal
  • care staff
  • scientific process

  • reporting requirements
  • complex animal
  • experimental procedures
  • fewer advances
  • complex diseases

  • reduce regulatory
  • questions pertaining
  • assurance statement
  • quantitative information
  • assurances demonstrating

  • hypotheses related
  • increasingly complex
  • changing standards
  • increase awareness
  • veterinary prereview

  • broad scientific
  • constitutes regulatory
  • growing urban
  • help reduce
  • interventions performed


    • This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
    More information on Chapter Skim is available.