Definition of Pain and Distress and Reporting Requirements for Laboratory Animals Proceedings of the Workshop Held June 22, 2000 (2000) / Chapter Skim
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Pages 71-76
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From page 71... ...
My nociceptive apparatus activated my physiological and behavioral responses through those rapidly receptive limbic and isocortical parts, especially my amygdala and somatosensory cortex. Then began my perceptions, whose true dimensions were known to me only.
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From page 72... ...
His initial answer was rapid, emphatic, and intuitive: "I believe placental mammals, despite some differences, due to modifiers of the responses, are very similar." Period. I learned also from three decades of books and articles that primate nociceptors, A-delta and C sensory fibers, spinal tracts, brain tracts, the limbic system, thalamus, somatosensory cortex, and brain/weight ratio seemed to be very, very similar to those in rats, even more alike than between those beloved cats and us human primates.
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From page 73... ...
The research investigators and active coinvestigators often have veterinary and PhD degrees, private and institutional practice experience, and speciality boards. They do not see distress and pain as I do, however, end both in 1994 andin 1997 our surgeons and anesthesiologists argued vigorously with the AAALAC visitors over valid signs of pain (no one mentioned distress)
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From page 74... ...
My colleagues do believe, however, what I read often: There are many tried and true methods for the reduction of distress and pain in animals if drugs and nondrug procedures used properly are study compatible and if considerable effort is made to define in clear, legal language the terms distress, pain, and perhaps some other, related terms. Rats and Your Cousins, I Love You In my 17 years, 8 on the AAALAC Council, as a site visitor and also as a part-time consultant to small Mississippi colleges with domestic rat and mice colonies only, I have seen hundreds to thousands of rodents and rabbits in their barren, sanitized twice a week plastic or metal or wire cages, on treadmills, abdomens open on surgery tables, burned by infrared light, injected with turpentine, living but with skin burned in a -17° F freezer, operated on without shaving, having their skulls drilled and spinning on rotating bits, carrying ulcerated tumors, all with no USDA oversight, little if any IACUC concern, scant environmental enrichment, and no perioperative distress and pain relief, drugs or otherwise.
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From page 75... ...
You will find me and our IACUC very receptive. In addition, I think in this country only the Guide and the USDA regulations, but regulations above all, can accomplish these goals, if the authors are sufficiently research wise and are willing to compromise on details, reduce debate, and promulgate practical and reasoned doctrines.
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From page 76... ...
2000. Recognizing pain and distress in laboratory animals.
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