Definition of Pain and Distress and Reporting Requirements for Laboratory Animals Proceedings of the Workshop Held June 22, 2000 (2000) / Chapter Skim
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Personal Experiences with Clinical Pain Management, Study Design, Mitigation of Scientific Cofounders, and Long-term Gains to the Researchers and Public
Personal Experiences with Clinical Pain Management, Study Design, Mitigation of Scientific Cofounders, and Long-term Gains to the Researchers and Public
Pages 77-81
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From page 77... ...
It is also a mistake to dwell on costs associated with increased provisions for monitoring and intervention programs because the relative savings are well known in terms of higher animal yields, smaller interanimal variability due to management of stressors, and shorter time from bench-to-bedside human trials. Thus, quality pain management programs result in more observations during experimentation and public assurances that are immeasurable.
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From page 78... ...
The model then undergoes the additional stress of serial MRI or angiographic episodes under general anesthesia. Then add the additional experiment whereby the investigator wishes to administer viral-mediated gene therapy using adenoviral vascular endothelial growth factor, and have a singular experiment within a multidimensional risk project.
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From page 79... ...
I made steady improvements, which included acquisition of an overnight technical staff, clinical chemistry and complete blood count analyzers that gave results instantly at the cageside, and the provision of scoring systems that augmented analgesic administration. Survival rates increased to 95%.
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From page 80... ...
SCIENTIFIC JOURNALS AS FACILITATORS I must mention literature because methods that describe adequate animal care and monitoring are frequently not part of scientific journal reporting. Many investigators argue that their science does not need refinement because the methods they are utilizing have been reproduced time and again according to proven methods.
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From page 81... ...
This system of veterinary collaboration, pilot design, and retrospective refinements and reporting affords more efficient experimental conduct with more accurate reporting of results and animal pain classification. REFERENCES Banai S., M.T.
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