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The History and Histrionics of Pain and Distress in Laboratory Animals
Pages 87-92

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From page 87...
... in 1966. Congressional Remarks I referred to the original congressional testimony on the AWA in an attempt to understand the intent of Congress regarding the alleviation of pain and distress and how these remarks translated into statutory law, regulations, and, later, policy implementation.
From page 88...
... Furthermore, he expressed the belief that institutions should provide references to research publications as part of their reporting requirement, hinting at responsibility of the scientists to demonstrate publicly the prudence and productivity of their animal research efforts. Pepper was a visionary (and/or had extraordinary staffers)
From page 89...
... Through the IACUC in collaboration with institutional veterinarians, we now have a structure and mechanism to tackle the remaining 5 to 10% of thorny pain and distress issues and to make sound decisions about the level of attention and intervention appropriate for problem areas on a case-by-case basis. ANTICIPATED CHANGES Multidimensional Impact Even without AWA regulation or policy change, we have extended our stewardship to the laboratory rat and mouse used in research by conforming to the principles of humane care and "good science." It is clear from the Animal Care Strategic Plan 2000 that the USDA-Animal Care anticipates expanding its authority in this area.
From page 90...
... One final point in the Animal Care Strategic Plan 2000 expresses the USDA's intention to "empower, support and develop employees." Although the concept of this intention is noble, I believe the appropriate order of events should be first to develop, then to support, and finally to empower employees. Empowered renegade employees can be a problem in any organization, but the lasting ramifications for careers of those regulated, institutional integrity, and cynicism toward regulations and regulators brings added importance to rigorous criteria for employee development in this arena.
From page 91...
... My solution to the language problem is minimalistic and simple: split USDA Category "E" into two categories, "E1" and "E2," and retain the original language for "E1." For Category E2, fashion some language to express our need to include other types of vague pain, distress, and suffering, which are poorly characterized and for which the anesthetics, analgesics, sedatives, and tranquilizers may not be deemed appropriate. I offer the following language for the new Category "E2": "Provide the common names and approximate numbers of animals used in applications that resulted in significant pain or distress but for which palliative efforts either were not undertaken or were deemed ineffective in the opinion of the IACUC and the attending veterinarian due to the type of pain or distress syndrome involved and the current status of applicable pharmacological and nonpharmacological therapeutic options." The language recommendations above represent my attempt to create a
From page 92...
... CONCLUSION I have always believed that complicated policy matters are best informed by the simplest and clearest expression of pnnciple. I want to leave you with a guiding principle that is taken from The Little Prince, by Antoine de Saint-Exupery (1943)


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