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Definition of Pain and Distress and Reporting Requirements for Laboratory Animals Proceedings of the Workshop Held June 22, 2000 (2000) / Chapter Skim
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Panel Discussion with All Speakers
Pages 93-98

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From page 93...
... You understand that there is a law called the Federal Advisory Committee Act that would keep us from simply assembling without going through a very complicated and due process and enlisting a group of experts to help us draft a policy, a regulation, or even guidelines. However, nothing keeps anyone from making suggestions to us, and we can assure you that we will give all suggestions due consideration, whether they are coming from an individual, an organization, or an association; from industry, the animal protection community, or simply the general public at large.
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From page 94...
... , they do experience distress despite the fact that they are given analgesics in response to visibly painful conditions, joint bleeds, and so forth. If you do revise Policy 11 with an acceptable definition of distress, it is very likely that these animals would clearly fit that definition of distress, and there still would be no place to record those animals on the annual report other than in Category C and/or E depending on their particular situation.
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From page 95...
... Rich, who is just one of many who have recently shared information with ILAR as we try to project the future, changing use of animals and identify the resulting cost implications. We have heard from a great number of people that because of our ability to manipulate the mouse genome, we will actually be able to actually create real models of real human disease and then try to understand the complex molecular events, identify some point where one could develop a small molecule that would interrupt the pathway, and ultimately develop a drug that could be used in humans to treat disease.
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From page 96...
... : Many people who breed transgenics actually breed heterozygotes so that the heterozygote is not typically sick; they cross two heterozygotes. There are ways of managing transgenic populations to offset or mitigate distress, although people without previous experience in managing distress would benefit from the exemplars Dr.
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From page 97...
... More input from a group such as our laboratory animal community will result in more "buy-in" when policies are in place.
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Key Terms

  • seek knowledge
  • professional judgment
  • proposed rule
  • human disease
  • animal welfare

  • laboratory animal
  • embryo freezing
  • advance notice
  • nih grants
  • institution unless

  • managing distress
  • treat disease
  • resulting cost
  • real human
  • disease process

  • gene knockout
  • actually create
  • experiences pain
  • law called
  • substantial transgenic

  • knockout manipulation
  • formal regulatory
  • appropriate category
  • ultimately question
  • real models

  • whatever category
  • feel uncomfortable
  • diseases involving
  • grants review
  • review policy


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