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Definition of Pain and Distress and Reporting Requirements for Laboratory Animals Proceedings of the Workshop Held June 22, 2000 (2000) / Chapter Skim
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Appendix A: APHIS/USDA Policy 11 and Policy 12
Pages 99-103

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From page 99...
... justification: Provides requested guidance. Procedures involving animals will avoid or minimize discomfort, distress and/or pain.
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From page 100...
... Animals exhibiting signs of pain, discomfort, or distress such as decreased appetite/activity level, adverse reactions to touching inoculated areas, open sores/ necrotic skin lesions, abscesses, lameness, conjunctivitis, corneal edema, and photophobia are expected to receive appropriate relief unless written scientific justification is provided in the animal activity proposal and approved by the IACUC. Research facilities must have a mechanism in place for ensuring that animals are reported in the appropriate pain category on the annual report (APHIS Form 7023~.
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From page 101...
... Toward this end, the regulations state that any proposed animal activity, or significant changes to an ongoing animal activity, must include: a rationale for involving animals, the appropriateness of the species, and the number of animals to be used; 2. a description of procedures or methods designed to assure that discomfort and pain to animals will be limited to that which is unavoidable in the conduct of scientifically valuable research, and that analgesic, anesthetic, and tranquilizing drugs will be used where indicated and appropriate to minimize discomfort and pain to animals; 3.
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From page 102...
... AWIC offers expertise in formulation of the search strategy and selection of key words and databases, access to unique databases, on- and off-site training of institute personnel in conducting effective alternatives searches, and is able to perform no-cost or low-cost electronic database searches. AWIC can be contacted at (301)
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From page 103...
... When a proposal is modified during its performance, significant changes are subject to prior review by the IACUC, including the review of the implications of those changes concerning the availability of alternatives. Although additional attempts to identify alternatives or alternative methods are not required by Animal Care at the time of each annual review of the animal protocol, Animal Care would normally expect the principal investigator to reconsider alternatives at least once every 3 years, consistent with the triennial review requirements of the Public Health Service Policy (IV,C,5~.
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Key Terms

  • alternative methods
  • animal care
  • slight pain
  • animal welfare
  • individual animals

  • animal activity
  • database search
  • antibody production
  • cfr references
  • subject expert

  • testing procedures
  • animal pain
  • consider alternatives
  • institutional animal
  • narrative description

  • welfare information
  • information center
  • concerning alternatives
  • distress consistent
  • regulations require

  • proposed animal
  • information service
  • normally expect
  • local lymph
  • including cfr

  • refine animal
  • replace animals
  • appropriate government
  • veterinary medical
  • regulations state


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