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2. Strategies for Future Research on Disease Mechanisms
Pages 4-5

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From page 4...
... They regarded the ongoing international initiative, "The MS Lesion Project," as fulfilling an important research question that a largescale initiative should address namely, whether there are distinct neuropathological subtypes of MS. This project, the largest ever supported by the National MS Society, integrates tissue samples and imaging in a longitudinal study design.
From page 5...
... Several participants noted the advantages of such a facility: primates' close biological fidelity to humans, their utility for uncovering medication safety problems prior to human clinical trials, and their role in teasing apart disease pathogenesis. The disadvantage is that a primate facility requires large, long-term investment that may not be fruitful.


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