Biographical Memoirs Volume 80 (2001) / Chapter Skim
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Alred Day Hershey
Alred Day Hershey
Pages 142-159
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a normal crop of new phage particles. Previous evidence implicating DNA in heredity hacl shown that a property of the surface coat of the pneumococcus bacterium conic!
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In 1950 Al became a staff member at the Department of Genetics, Carnegie Institution of Washington, CoIcl Spring Harbor, New York, in 1962 he was appointed director of the Genetics Research Unit of that institution. Al was elected!
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Louis Al ~ ~ 95 ~ ~ showocl that phage particles were "killecI" by the clecay of the unstable isotope 32p incorporatecl within their DNA. After the central importance of DNA to the phage life cycle (ancl to genetics)
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, however heterozygous particles, which contain two different alleles at a single locus, were described by Hershey and Chase ~952,2) at the ~95~ Cold Spring Harbor Symposium.
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Several subsequent papers refined the conclusions of the blencler experiment by showing, for instance, that some protein is injected along with the phage DNA (1955~. With Watson-Crickery well establishecl by this time these studies were interesting but not threatening to the view that the genetic substance was DNA.
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physical cliscontinuities (Doermann en cl Boehner, 1963~. A major insight into the structure of T-even phage chromosomes resulted from attempts to reconcile the apparently contradictory physical en c!
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circular linkage map provided an elegant frame for displaying the functional organization of the T4 chromosome, as revealecl by the pioneering studies of Epstein et al.
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physical substance to Alan Campbell's ~ ~ 962 ) proposal that the attachment of ~ prophage to the host chromosome involves crossing over between the host chromosome en c!
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breakage en c! clenaturation as well as methods that wouIcl break phage chromosomes into halves and quarters, and the calibration of methods for measuring molecular weights of DNA.
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at CoIcl Spring Harbor, which hostecl huncirecis of visitors every summer. That's because Al spent his summers sailing in Michigan, en c!
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, who recallec! that Al, whose research support was guaranteed by the Carnegie Institution, arguccl with Carnegie directors for the right to apply for NIH support so that he might benefit from the critiques of his peers.
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From page 154... ...
That we offer with the usual human mixture of pride and diffidence. Those who workocl with Hershey at CoIcl Spring Harbor inclucle Phyllis Bear, Elizabeth Burgi, John Cairns, Connie Chadwick, Martha Chase, CarIo Cocito, Rick Davern, Gus Doermann, Ruth Ehring, Stanley Forman, Frecl Frankel, Dorothy Fraser, Alan Garen, Eciclie Goiciberg, June Dixon Huclis, Laura Ingraham, Gebharcl Koch, Ancire Kozinsky, Nacia Leclinko, CyLevinthal, Shraga Makover, foe Manclell, Norman Melechen, Teiichi Minagawa, Gisela Mosig, Davic!
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. New York: Cold Spring Harbor Laboratory Press.
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Hershey and the Origins of Molecular Biology. New York: Cold Spring Harbor Laboratory Press.
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Genetic recombination between host-range and plaque-type mutants of bacteriophage in single bacterial cells. Genetics 34:44-71.
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Genetic recombination and heterozygosis in bacteriophage. Cold Spring Harbor Symp.
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From page 159... ...
1963 Annual report of the director of the Genetics Research Unit. Carnegie Institution of Washington Yearbook 62:461-500.
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