Biographical Memoirs Volume 80 (2001) / Chapter Skim
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David Rittenberg
David Rittenberg
Pages 256-275
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From page 257... ...
The metabolites containing 2H hacl properties essentially inclistinguishable from their natural analogs by the methods commonly usecI. Nevertheless, the presence of the isotope macle it possible to trace their metabolic fate.
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From page 258... ...
The study of the metabolism of substances which occur in nature in large amounts and are continually synthesized and destroyed in the animal body presents almost insuperable difficulties. If substances such as natural fatty acids, amino acids, etc., are administered to an animal, we lose track of them the moment they enter the body, since they are mixed with the same substances already present.
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From page 259... ...
5 Hours before the first, and five hours after the last coprostanone meal he ate grapes, the seeds of which served as an indicator in the stools.... The isolation of the sterols was performed on the portion of stool excreted between the two grape seed markers, in which the greatest concentration of the newly formed coprosterol was to be expected.
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From page 260... ...
In particular, the second part of the deuterium series contains methods for the generation Of 2H as gas, the combustion of samples to water, follower! by purification by clistillation, en c!
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From page 261... ...
A particularly significant observation was that when mice were feel 2H-labelecl fatty acids, most of the 2H was recoverecl in the fat tissues rather than being immecliately utilized. Of the 15 papers in the cleuterium series only the last was not coauthored by Rittenberg, en cl ~ of them were authored only by Rittenberg en cl Schoenheimer.
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From page 262... ...
The first i5N work at PUS was a study of hippuric acid metabolism in 1937. By this time the isotope group hac!
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From page 263... ...
that "the nitrogen isotope shouic! prove to be as useful in the study of the intermediary metabolism of nitrogen compounds as cleuterium is in the stucly of fat en c!
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From page 264... ...
The large, complex macromolecules were constantly involvecl in rapicl chemical reactions with their smaller component units, a continuing en c! constant process of clegraciation en c!
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From page 265... ...
At stated intervals blood was withdrawn en cl the i5N concentration of bloocl proteins was cleterminecI. The ciata were consistent with the concept of the dynamic state of hotly constituents.
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From page 266... ...
The dynamics of reel cell survival in patients with polycythemia Vera, sickle cell anemia, en c! pernicious anemia were clescribec!
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From page 267... ...
An organic chemist was neeclec! to synthesize labelecl compounds, a physical chemist to builcl en cl operate the complex instruments for measuring isotope ratios, a physicist to provicle concentrates!
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From page 268... ...
Rittenberg's contributions to the isotope tracer technique were recognized in 1941 by the Eli Lilly Awarcl in Biological Chemistry from the American Chemical Society, Division of Biological Chemistry. A further recognition was his election to the National Academy of Sciences in 1953.
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From page 269... ...
He sail! that "Hevesy, to employ terms suitable to a biological science, was not only one of the fathers of the isotope technique but also the attending gynecologist." Modesty on Rittenberg's part clicl not allow him to describe himself as one of the founcling fathers.
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From page 270... ...
Many inclivicluals remember superb meals prepared by Sara. As a youth Rittenberg hacl contractual rheumatic fever en cl his cleath on January 24, 1970, was from heart disease.
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From page 271... ...
While this possibility has now been long establishecI, it has also become possible to investigate stereochemical problems in compounds containing all three hydrogen isotopes, Ca~H2H3H. Work with "chiral methyl groups" is now well known en cl similar work with the three oxygen isotopes has concerned "chiral phosphate groups" in compounds such as Ro-Pi60~70~80.
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From page 272... ...
The normal abundance of nitrogen isotopes in amino acids.
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From page 273... ...
The life span of the human red blood cell.
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From page 274... ...
II. Measure of the metabolic pool and the rate of protein synthesis.
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