Biographical Memoirs Volume 80 (2001) / Chapter Skim
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Ruth Sager
Ruth Sager
Pages 276-289
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From page 277... ...
In the first she was a leacling exponent of organelle, non-nuclear genetics, in the second she was a major innovator in cancer genetics, proposing, discovering, and investigating roles of tumor suppressor genes. At the pinnacle of research on the problem of non-nuclear or cytoplasmic genetics for many years, she almost single-hanclecIly clevelopecl this subject of non-Menclelian, cytoplasmic genetics ("A vast, unexplored!
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From page 278... ...
in breast cancers, such as the mammary serpin maspin. She workocl to the end, publishing innovative articles en cl obtaining a National Institute of Health grant in the month before her cleath.
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From page 279... ...
among the first women to gain a full professorship at Harvard en cl chief of the Division of Cancer Genetics at the Dana-Farber Cancer Institute. She was also a Guggenheim fellow at the Imperial Cancer Research FuncI, London, cluring 1972-73, en cl was electecl to membership of the National Academy of Sciences in 1977.
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From page 280... ...
Among her honors and distinctions were Phi Beta Kappa in 1938, Sigma Xi in 1947, Guggenheim Fellowship in 1972, Schneider Memorial Lecture Awarcl in 1973, National AcacIemy of Sciences membership in 1977, American Academy of Arts en cl Sciences membership in 1978, Harvey Society Lecture in 1984, outstanding investigator at the National Cancer Institute in 1985, Gilbert Morgan Smith Mecial from the National Academy of Sciences in 1988, membership in the Institute of Medicine in 1992, Princess Takamatsu Awarcl (Japan) in 1992, alumni medallist of the University of Chicago in 1994, en cl membership on the Acivisory Council of the National Institute on Aging.
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From page 281... ...
· Developecl a system that makes genetic mapping possible by permitting expression of paternal genes. · Developecl several mapping methods en cl first publishecl cytoplasmic linkage groups en cl extensive mapping of an organelle.
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From page 282... ...
resource for anticancer therapy."2 Sager suggested a yin-yang balance of these for cellular homeostasis. Among her cancer research accomplishments were the following: · She clevelopecl a moclel system that allows cletailecl comparisons in the same culture meclium between wellmatchecl normal en cl tumor Chinese hamster embryo fibroblasts (CHEF celIs)
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From page 283... ...
For this purpose she creates! a workable human breast cancer cell culture system in which normal en cl tumor epithelial cells couIcl grow en cl at similar rates.
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From page 284... ...
She was a role moclel for many women, being among the earliest successful woman scientists in spite of major career obstacles, but she was never highly active in the women's liberation movement. When facecl with the built-in prejudice of the male scientific community against women, she responclec!
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From page 285... ...
R U T H S A G E R NOTES 285 1. The unattributed quoted material in this memoir is derived from personal conversations with Ruth Sager.
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From page 286... ...
Biparental inheritance of nonchromosomal genes induced by ultraviolet irradiation.
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Multistep origin of tumor-forming ability in Chinese hamster embryo fibroblast cells. Cancer Res.
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Kalesa. Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements.
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From page 289... ...
Linking gene expression patterns to therapeutic groups in breast cancer. Cancer Res.
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