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Making Sense of Complexity Summary of the Workshop on Dynamical Modeling of Complex Biomedical Systems (2002) / Chapter Skim
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4 Modeling with Compartments
Pages 15-17

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From page 15...
... Byron Goldstein, of Los Alamos National Laboratory, presented work that he thought fell under the first and third of these classifications. He described mathematical models used for studying immunoreceptor signaling that is initiated by different receptors in general organisms.
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From page 16...
... Goldstein has used deterministic and stochastic approaches to create the following detailed models of cell signaling: · An algorithm has been created to generate the chemical rate equations that describe the dynamics of the average concentrations of chemical species involved in a generic signaling cascade. · A stochastic model for the time dependence of the state concentrations has been developed, and it has been shown that the stochastic and deterministic formulations agree in the cases studied to date.
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From page 17...
... * IS ~ V~IR FIGURE 4-1 Compartment model for the epidemiology of the antibiotic therapy of prophylaxis.
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Key Terms

  • signaling cascade
  • biomedical processes
  • adapter proteins
  • deterministic formulations
  • common themes

  • emory university
  • detailed features
  • goldstein developed
  • chemical species
  • suggest conceptual

  • studying immunoreceptor
  • participating molecules
  • biophysical processes
  • biological function
  • useful predictive

  • regulation mechanisms
  • serious public
  • predictive model
  • equations model
  • promotes cell

  • average concentrations
  • address detailed
  • growth factor
  • bioengineering design
  • mathematical model

  • cell signaling
  • immune response
  • quantitative predictions
  • state concentrations
  • time dependence


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