(NAS Colloquium) Molecular Kinesis in Cellular Function and Plasticity (2002) / Chapter Skim
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Pages 105-110
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From page 105... ...
These results suggested that protein synthesis at the synapse might be an important aspect of synaptic plasticity. This paper was presented at the Nationai Academy of Sciences colloquium, "Molecular Kinesis in Ceiiuiar Function and Piasticity," held December 7-9, 2000, at the Arnoid and Mabel Beckman Center in Irvine, CA.
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From page 106... ...
Thus, we concluded that the FMR-1 mRNA is taken up into translational complexes in response to mGluR1 agonist application. Fragile X syndrome is the most common form of inherited mental retardation, affecting, by one recent estimate, nearly 1 in 2,000 males and roughly half as many females (19~.
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From page 107... ...
. The absence of neurotransmitter-evoked protein synthesis in the synaptoneurosome preparation is paralleled by evidence for reduced protein synthesis at synapses in vivo.
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From page 108... ...
We followed up this work with quantitative measurements on layer V pyramidal neurons of Golgi-Kopsch-impregnated human autopsy material from temporal and occipital cerebral cortex from three adult male patients with fragile X syndrome (for each area) and three age-matched male controls (for B ~ 6C I U: 4; 4 3C 15 ~ 20 laid FraX ~ ~ ~ ~ ~ 15 :]
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From page 109... ...
4. Spines in the fragile X samples were significantly longer overall and exhibited a morphology consistent with that of early development: a greater number of long spines with heads and fewer short, stubby, and mushroom-shaped spines were evident in the fragile X cases.
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From page 110... ...
25. Irwin, S
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