(NAS Colloquium) Molecular Kinesis in Cellular Function and Plasticity (2002) / Chapter Skim
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Pages 105-110
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From page 105... ...
These results suggested that protein synthesis at the synapse might be an important aspect of synaptic plasticity. This paper was presented at the Nationai Academy of Sciences colloquium, "Molecular Kinesis in Ceiiuiar Function and Piasticity," held December 7-9, 2000, at the Arnoid and Mabel Beckman Center in Irvine, CA.
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From page 106... ...
Among these clones was one that showed a striking increase in polyribosomal association after mGluR1 stimulation and that showed sequence homology to both FMR-1 (the fragile X mental retardation gene) and the related molecule FXR1.
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From page 107... ...
. We used these mice for a direct test of a role for FMRP in protein synthesis near synapses.
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From page 108... ...
We followed up this work with quantitative measurements on layer V pyramidal neurons of Golgi-Kopsch-impregnated human autopsy material from temporal and occipital cerebral cortex from three adult male patients with fragile X syndrome (for each area) and three age-matched male controls (for B ~ 6C I U: 4; 4 3C 15 ~ 20 laid FraX ~ ~ ~ ~ ~ 15 :]
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From page 109... ...
(1996) Fragile X Syndrome: Diagnosis, Treatment, and Research (Johns Hopkins Univ.
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From page 110... ...
25. Irwin, S
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