(NAS Colloquium) Molecular Kinesis in Cellular Function and Plasticity (2002) / Chapter Skim
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Pages 22-28
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mRNAs shown to be affected following overexpression of Hu proteins include glucose trans ~ ~ , ~ ~ This paper was presented at the National Academy of Sciences colloquium, "Molecular Kinesis in Cellular Function and Plasticity," held December 7-9, 2000, at the Arnold and Mabel Beckman Center in Irvine, CA. Abbreviations: mRNP, ribonucleoprotein; ERG, early response gene; ARE, AU-rich elements; NF-M, neurofilament M protein; RRM, RNA recognition motif (RRM)
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Fig.
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Density Accudenz Gradients A Control ~ .
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For example, mRNAs encoding transcription factors appear to be packaged in the cytoplasm at distances far from the nucleus, and their localized expression in response to external stimuli may influence cellular mechanisms in the nucleus (39, 40, 47~. As noted above, many of the mRNAs to which the ELAV/Hu proteins bind encode transcription factors, including CREB, ERG-1, fos, myc, and Id (1-9~.
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set of protein components. Gaining access to these putative mRNA subsets requires an ability to isolate mRNPs by using biochemical procedures.
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Transcriptome S;2,~r, ~ mRNP 2 9mRNP 1 Proteome A_ Ribonome Nuclear Run-On mRNP ~ mRNP 2 mRNP X mRNPX Fig.
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posttranscriptional effects such as mRNA stability by distinguishing those genes exclusively regulated at the level of transcription. Similar approaches for multiplexing splicing reactions and translation are imaginable, and will be necessary to fully understand the posttranscriptional network operating system.
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