(NAS Colloquium) Molecular Kinesis in Cellular Function and Plasticity (2002) / Chapter Skim
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Pages 49-54
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From page 49... ...
Purified ODNs were lyophilized and resusThis paper was presentec] at the Nationa~ Acaclemy of Sciences colloquium, "Molecular Kinesis in Ceiluiar Function anc!
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Therefore, we subjected the cells to a more rigorous analysis of their motility to ascertain which of the components of cell motility was most affected. To do this we correlated various aspects of cell motility with 13-actin mRNA localization.
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2, which shows that cells with delocalized 13-actin mRNA exhibit random directionality of motility and have less persistence in the direction of motility whereas control cells move with fixed polarity and linear directionality and are more persistent in the direction of motility (Table 3~. This finding indicates that mRNA localization is not necessary for the ability of the cells to move, but rather for their ability to maintain this movement in one direction.
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From page 52... ...
polymerization and consequently, cell polarity and directional motility. The molecular mechanism by which polarity of cell crawling is affected by I3-actin mRNA localization could depend on several interdependent events: (i)
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From page 53... ...
Newly formed actin filaments could interact with ,B-actin isoform-specific binding proteins, thereby stabilizing the cell polarity and consequent directional motility (29~. The leading edge of the cell is a complex composite of asymmetrically distributed proteins many of which function in concert to produce the motility response.
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From page 54... ...
8. Bailly, M., Macaluso, F., Cammer, M., Segall, J
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