(NAS Colloquium) Molecular Kinesis in Cellular Function and Plasticity (2002) / Chapter Skim
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Pages 84-89
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From page 84... ...
at the Nationai Acaclemy of Sciences colloquium, "Molecular Kinesis in Cellular Function anc] Plasticity," helc]
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The regulated transport of mRNA into neuronal dendrites recently has become a topic of examination by a number of groups. One approach to determining the rates of mRNA transport into dendrites is to treat neuronal cells with various PNAS 1 June 19, 2001 1 vol.
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From page 86... ...
Visualization and additional characterization of these in vivo translation sites will permit a careful dissection of the kinetics and biology of stimulated protein synthesis in dendrites. Discovery of a Second Messenger System in Dendrites The identification of multiple dendritically localized mRNAs and the evidence of local dendritic translation suggests that translation of mRNA in dendrites may produce proteins that serve various biological functions.
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From page 88... ...
The complexities of the biological processes and information processing that occur within the dendrite suggest that the dendrite should be viewed as the primary site for filtering and modulating presynaptic input into the neuron. As highlighted in this manuscript and others from the National Academy of Sciences colloquium, data collected during the last decade have provided extensive information concerning the molecular composition of neuronal dendrites.
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From page 89... ...
(2001) in Cell Polarity and Subcellular RNA Localization, ed.
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