(NAS Colloquium) Molecular Kinesis in Cellular Function and Plasticity (2002) / Chapter Skim
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Pages 84-89
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From page 84... ...
at the Nationai Acaclemy of Sciences colloquium, "Molecular Kinesis in Cellular Function anc] Plasticity," helc]
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The regulated transport of mRNA into neuronal dendrites recently has become a topic of examination by a number of groups. One approach to determining the rates of mRNA transport into dendrites is to treat neuronal cells with various PNAS 1 June 19, 2001 1 vol.
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and through the use of synaptoneurosome preparations to show that radioactivity could be incorporated into a product whose synthesis was diminished by protein synthesis inhibitors (7, 11~. Conclusive evidence that protein synthesis can occur in dendrites was provided by transfecting isolated dendrites with mRNA constructs that encode a protein fused to an epitope tag (c-myc)
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From page 88... ...
The complexities of the biological processes and information processing that occur within the dendrite suggest that the dendrite should be viewed as the primary site for filtering and modulating presynaptic input into the neuron. As highlighted in this manuscript and others from the National Academy of Sciences colloquium, data collected during the last decade have provided extensive information concerning the molecular composition of neuronal dendrites.
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From page 89... ...
16. Estee Kacharmina, J., Job, C., Crino, P
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