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James van Gundia Neel
Pages 214-233

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From page 215... ... Fortunately, the community his mother selectecl was the home of the College of Wooster, a small but outstanding liberal arts college to which he won a scholarship. {im's career directions were not fixed when he entered college. Read the entire page →
From page 216... ... Some, like his colleague Charles Cotterman, bookocl passage on the British passenger ship Athenia, which was torpecloec! on September 3, en c! Read the entire page →
From page 217... ... This provision macle it possible for women, upon registering their pregnancies with the local government, to obtain rational foocl to sustain themselves en cl their unborn offspring through gestation, en c! clothing for the infant once the chiTc! Read the entire page →
From page 218... ... When Linus PauTing and his colleagues (1949) showed that sickle cell anemia was a molecular disease, Tim initiated a series of electrophoretic studies of families resident in Michigan, to further the understanding of the frequency of abnormal hemoglobins in Africa, he developed a working relationship with the Liberian Institute of Tropical Medicine. Read the entire page →
From page 219... ... When these studies began, little was certain about the effects of consanguineous marriages. It was known that the chilciren of relatecl parents were more likely to be homozygous for a rare gene than were chiTciren whose parents were not relatecl to one another. Read the entire page →
From page 220... ... mutations. The aim of the latter search was not merely to count newly arisen mutations but also to estimate their longterm health impact. Read the entire page →
From page 221... ... He reasoner! that a stucly of their lives might provide insight into the general nature of human ancestral selective pressures, with consequences for human health (1958~. Read the entire page →
From page 222... ... since then, has been influential in shaping our perception of human genetic diversity. The continued existence of 15,000 or so samples collectecl 30 or more years ago ensures that this scientific legacy will be profitably mined for many years to come. Read the entire page →
From page 223... ... If the variant is not found in one or the other parent and if an error in assigning parentage is improbable, it presumably represents a new mutation. To establish parentage (since a priori the probability that the putative parents might not be the real parents is several orders of magnitude larger than the probability of a new mutation) Read the entire page →
From page 224... ... to aciciress a question of importance to contemporary public health en cl to give a perspective on evolutionary biology. Moreover, in the measurement of mutation rates it shifted the focus from crude phenotypes (the product of a complex web of gene-environment interactions) Read the entire page →
From page 225... ... Analysis of the difference between two samples in the distribution of these products defies easy visual examination. This fact lee! Read the entire page →
From page 226... ... If a threacl exists, however, it is the phenomenon of mutation. His interest began at Dartmouth College, was whetted by his association with Philip Ives en cl Ernst Haclorn, en cl continual throughout his long connection with the studies in Japan. Read the entire page →
From page 227... ... Among these eclitorial boards were those of Blood, Perspectives in Biology and Medicine, Proceedings of the National Academy of Sciences, Behavioral Genetics, Mutation Research, Journal of Molecular Evolution, Clinical Genetics, and Genetic Epidemiology, to mention only a few. The agencies he aiclecl incluclecl the National Institutes of Health, Department of Energy, Environmental Protection Agency, National Council on Racliation Protection en c! Read the entire page →
From page 228... ... He was cleeply concerned! with the Tot of his fellow kind as his autobiographical book Physician to the Gene Pool (1994) Read the entire page →
From page 229... ... unethically importecl a measles epidemic into the Venezuelan outback to further his interest in the biology of immune response to exogenous infectious pathogens (Tierney, 2000~. It was allegecl that this epidemic lecl to the cleaths of huncirecis, if not thousands, of inclivicluals who were ill prepared immunologically to cope with the new virus. Read the entire page →
From page 230... ... 1949. Sickle cell anemia: A molecular disease. Read the entire page →
From page 231... ... 74:185-96. 1947 The clinical detection of the genetic carriers of inherited disease. Read the entire page →
From page 232... ... 3:43-72. 1962 Diabetes mellitus: A "thrifty" genotype rendered detrimental by "progress"? Read the entire page →
From page 233... ... The Children of Atomic Bomb Survivors: A Genetic Study. Washington, D Read the entire page →

From page 215...

... Fortunately, the community his mother selectecl was the home of the College of Wooster, a small but outstanding liberal arts college to which he won a scholarship. {im's career directions were not fixed when he entered college.

James van Gundia Neel Pages 214-233

James van Gundia Neel
Pages 214-233