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8 Effects of Jet-Propulsion Fuel 8 on the Kidney
Pages 101-112

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From page 101...
... SUMMARY OF STUDIES DISCUSSED IN THE 1996 NATIONAL RESEARCH COUNCIL REPORT The National Research Council Subcommittee on Permissible Exposure Levels for Military Fuels reviewed studies on the toxic effects of the vapors of JP-5, JP-8, and diesel fuel marine (D FM) on the kidney (NRC 19969.
From page 102...
... Air Force bases (AFBs) : Davis Monthan AFB, Arizona; Seymour Johnson AFB, North Carolina; Langley AFB, Virginia; Pope, AFB, North Carolina; Little Rock AFB, Arkansas; and Hurlbert Field, Florida.
From page 103...
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From page 104...
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From page 105...
... The high-exposure group comprised subjects routinely performing tasks associated with repair of aircraft fuel systems; the moderate-exposure group comprised subjects involved in fuel handling, distribution, recovery, and testing; and the lowexposure group does not normally come into contact with jet fuel. There was no statistically significant change in urinary alpha-GST or pi-GST concentrations among any of the groups.
From page 106...
... With respect to renal function, serum sodium and chloride concentrations increased only in the high-dose group. Serum creatinine concentrations increased in the low- and middle-dose groups but not in the high-dose group; however, urinary creatinine and protein concentrations were not significantly altered by JP-8.
From page 107...
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From page 109...
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From page 110...
... The concentrations of 21 proteins increased, and the concentrations of 35 proteins decreased; these 56 proteins accounted for 6% of all total resolved proteins. Only a single time-point and only one concentration were used, and the relevance of the findings to human health risk is not established.
From page 111...
... 1991. The human relevance of the renal tumor-inducing potential of d-limonene in male rats: Implications for risk assessment.
From page 112...
... Pp. 81-86 in ~P-8 Final Risk Assessment Report.


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